{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T21:14:06Z","timestamp":1794086046599,"version":"4.8.0"},"reference-count":33,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1134\/s1607672924600556","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T10:03:22Z","timestamp":1724839402000},"page":"420-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aerobic Exercise Activates AMPK\/PGC-1\u03b1 Pathway, Inhibits Cardiomyocyte Apoptosis Improves Mitochondrial and Infarcted Heart Function"],"prefix":"10.1134","volume":"518","author":[{"given":"Qiu","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"137","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"7577_CR1","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1007\/s12015-021-10314-8","volume":"18","author":"A. Sharma","year":"2022","unstructured":"Sharma, A., Gupta, S., Archana, S., et al., Emerging trends in mesenchymal stem cells applications for cardiac regenerative therapy: current status and advances, Stem Cell Rev. Rep., 2022, vol. 18, no. 5, pp. 1546\u20131602.","journal-title":"Stem Cell Rev. Rep."},{"key":"7577_CR2","doi-asserted-by":"publisher","first-page":"e2204999","DOI":"10.1002\/advs.202204999","volume":"10","author":"Q. Sun","year":"2023","unstructured":"Sun, Q., Ma, H., Zhang, J., et al., A self-sustaining antioxidant strategy for effective treatment of myocardial infarction, Adv. Sci. (Weinheim), 2023, vol. 10, no. 5, p.\u00a0e2204999.","journal-title":"Adv. Sci."},{"key":"7577_CR3","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1093\/eurjpc\/zwad024","volume":"30","author":"J. Ruivo","year":"2023","unstructured":"Ruivo, J., Moholdt, T., and Abreu, A., Overview of cardiac rehabilitation following post-acute myocardial infarction in European Society of Cardiology member countries, Eur. J. Preventive Cardiol., 2023, vol. 30, no.\u00a09, pp. 758\u2013768.","journal-title":"Eur. J. Preventive Cardiol."},{"key":"7577_CR4","doi-asserted-by":"publisher","first-page":"12341","DOI":"10.3390\/ijms222212341","volume":"22","author":"Y. Ma","year":"2021","unstructured":"Ma, Y., Kuang, Y., Bo, W., et al., Exercise training alleviates cardiac fibrosis through increasing fibroblast growth factor 21 and regulating TGF-\u03b21-Smad2\/3-MMP2\/9 signaling in mice with myocardial infarction, Int. J. Mol. Sci., 2021, vol. 22, no. 22, p. 12341.","journal-title":"Int. J. Mol. Sci."},{"key":"7577_CR5","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.3892\/mmr.2020.11241","volume":"22","author":"Q. Si","year":"2020","unstructured":"Si, Q., Shi, Y., Huang, D., et al., Diosmetin alleviates hypoxia-induced myocardial apoptosis by inducing autophagy through AMPK activation, Mol. Med. Rep., 2020, vol. 22, no. 2, pp. 1335\u20131341.","journal-title":"Mol. Med. Rep."},{"key":"7577_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40360-021-00542-6","volume":"23","author":"L. Xiao","year":"2022","unstructured":"Xiao, L., Xu, C., Lin, P., et al., Novel dihydroartemisinin derivative Mito-DHA(5) induces apoptosis associated with mitochondrial pathway in bladder cancer cells, BMC Pharmacol. Toxicol., 2022, vol. 23, no. 1, p. 10.","journal-title":"BMC Pharmacol. Toxicol."},{"key":"7577_CR7","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.3390\/ijms23042357","volume":"23","author":"S. Zhang","year":"2022","unstructured":"Zhang, S., Rao, S., Yang, M., et al., Role of mitochondrial pathways in cell apoptosis during hepatic ischemia\/reperfusion injury, Int. J. Mol. Sci., 2022, vol. 23, no. 4, p. 2357.","journal-title":"Int. J. Mol. Sci."},{"key":"7577_CR8","doi-asserted-by":"publisher","first-page":"23705","DOI":"10.1002\/jcp.28939","volume":"234","author":"D. Jia","year":"2019","unstructured":"Jia, D., Hou, L., Lv, Y., et al., Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1\/PGC-1\u03b1\/PI3K\/Akt signaling, J. Cell Physiol., 2019, vol. 234, no. 12, pp. 23705\u201323718.","journal-title":"J. Cell Physiol."},{"key":"7577_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00424-020-02357-6","volume":"472","author":"M.H. No","year":"2020","unstructured":"No, M.H., Heo, J.W., Yoo, S.Z., et al., Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart, Pflugers Arch., 2020, vol. 472, no. 2, pp. 179\u2013193.","journal-title":"Pflugers Arch."},{"key":"7577_CR10","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.hlc.2020.08.004","volume":"30","author":"J. Zhang","year":"2021","unstructured":"Zhang, J., Huang, C., Meng, X., et al., Effects of different exercise interventions on cardiac function in rats with myocardial infarction, Heart, Lung Circ., 2021, vol. 30, no. 5, pp. 773\u2013780.","journal-title":"Heart, Lung Circ."},{"key":"7577_CR11","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1038\/s41401-021-00763-9","volume":"43","author":"F. Qiu","year":"2022","unstructured":"Qiu, F., Yuan, Y., Luo, W., et al., Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism, Acta Pharmacol. Sin., 2022, vol. 43, no. 6, pp. 1395\u20131407.","journal-title":"Acta Pharmacol. Sin."},{"key":"7577_CR12","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3390\/antiox12051075","volume":"12","author":"O. Abu Shelbayeh","year":"2023","unstructured":"Abu Shelbayeh, O., Arroum, T., Morris, S., et al., PGC-1\u03b1 is a master regulator of mitochondrial lifecycle and ROS stress response, Antioxidants (Basel), 2023, vol. 12, no. 5, p. 1075.","journal-title":"Antioxidants"},{"key":"7577_CR13","doi-asserted-by":"publisher","first-page":"8047752","DOI":"10.1155\/2023\/8047752","volume":"2023","author":"X. Zhang","year":"2023","unstructured":"Zhang, X., Wu, X., Hu, H., et al., DT-010 exerts cardioprotective effects by regulating the crosstalk between the AMPK\/PGC-1\u03b1 pathway and ERp57, Cardiovasc. Ther., 2023, vol. 2023, p. 8047752.","journal-title":"Cardiovasc. Ther."},{"key":"7577_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.pcad.2023.04.008","volume":"79","author":"A. Isath","year":"2023","unstructured":"Isath, A., Kozilol, K.J., Martinez, M.W., et al., Exercise and cardiovascular health: a state-of-the-art review, Prog. Cardiovasc. Dis., 2023, vol. 79, pp. 44\u201352.","journal-title":"Prog. Cardiovasc. Dis."},{"key":"7577_CR15","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1093\/eurheartj\/ehad170","volume":"44","author":"P.L. Valenzuela","year":"2023","unstructured":"Valenzuela, P.L., Ruilope, L.M., Santos-Lozano, A., et al., Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation, Eur. Heart J., 2023, vol. 44, no. 21, pp. 1874\u20131889.","journal-title":"Eur. Heart J."},{"key":"7577_CR16","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1139\/apnm-2023-0135","volume":"49","author":"X. Guo","year":"2024","unstructured":"Guo, X., Qu, F.X., Zhang, J.D., et al., Amygdalin and exercise training exert a synergistic effect in improving cardiac performance and ameliorating cardiac inflammation and fibrosis in a rat model of myocardial infarction, Appl. Physiol., Nutr., Metab., 2024, vol. 49, no. 3, pp. 360\u2013374.","journal-title":"Appl. Physiol., Nutr., Metab."},{"key":"7577_CR17","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.3390\/cells9092121","volume":"9","author":"S. Ladokhin","year":"2020","unstructured":"Ladokhin, S., Regulation of apoptosis by the Bcl-2 family of proteins: field on a brink, Cells, 2020, vol. 9, no. 9, p. 2121.","journal-title":"Cells"},{"key":"7577_CR18","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1111\/jcmm.16329","volume":"25","author":"L. Chen","year":"2021","unstructured":"Chen, L., Li, S., Zhu, J., et al., Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1\/FoxO3a pathway, J. Cell Mol. Med., 2021, vol. 25, no. 6, pp. 2944\u20132955.","journal-title":"J. Cell Mol. Med."},{"key":"7577_CR19","doi-asserted-by":"publisher","first-page":"117958","DOI":"10.1016\/j.lfs.2020.117958","volume":"256","author":"R. Fathi","year":"2020","unstructured":"Fathi, R., Nasiri, K., Akbari, A., et al., Exercise protects against ethanol-induced damage in rat heart and liver through the inhibition of apoptosis and activation of Nrf2\/Keap-1\/HO-1 pathway, Life Sci., 2020, vol. 256, p. 117958.","journal-title":"Life Sci."},{"key":"7577_CR20","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1093\/cvr\/cvad100","volume":"119","author":"L. Da Dalt","year":"2023","unstructured":"Da Dalt, L., Cabodevilla, A.G., Goldberg, I.J., et al., Cardiac lipid metabolism, mitochondrial function, and heart failure, Cardiovasc. Res., 2023, vol. 119, no. 10, pp. 1905\u20131914.","journal-title":"Cardiovasc. Res."},{"key":"7577_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00395-023-01019-9","volume":"118","author":"S. Hernandez-Resendiz","year":"2023","unstructured":"Hernandez-Resendiz, S., Prakash, A., Loo, S.J., et al., Targeting mitochondrial shape: at the heart of cardioprotection, Basic Res. Cardiol., 2023, vol. 118, no. 1, p. 49.","journal-title":"Basic Res. Cardiol."},{"key":"7577_CR22","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41401-021-00671-y","volume":"43","author":"Y.F. Liu","year":"2022","unstructured":"Liu, Y.F., Zhang, L., Wu, Q., et al., Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c\/caspase3\/HDAC4 pathway, Acta Pharmacol. Sin., 2022, vol. 43, no. 2, pp. 273\u2013284.","journal-title":"Acta Pharmacol. Sin."},{"key":"7577_CR23","doi-asserted-by":"publisher","first-page":"10618","DOI":"10.1038\/s41598-020-67457-w","volume":"10","author":"S. Noh","year":"2020","unstructured":"Noh, S., Phorl, S., Naskar, R., et al., p32\/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis, Sci. Rep., 2020, vol. 10, no. 1, p. 10618.","journal-title":"Sci. Rep."},{"key":"7577_CR24","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1002\/jcp.30869","volume":"237","author":"K.S. Vikramdeo","year":"2022","unstructured":"Vikramdeo, K.S., Sudan, S.K., Singh, A.P., et al., Mitochondrial respiratory complexes: Significance in human mitochondrial disorders and cancers, J. Cell Physiol., 2022, vol. 237, no. 11, pp. 4049\u20134078.","journal-title":"J. Cell Physiol."},{"key":"7577_CR25","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12967-023-03873-6","volume":"21","author":"C. Piamsiri","year":"2023","unstructured":"Piamsiri, C., Maneechote, C., Jinawong, K., et al., GSDMD-mediated pyroptosis dominantly promotes left ventricular remodeling and dysfunction in post-myocardial infarction: a comparison across modes of programmed cell death and mitochondrial involvement, J. Transl. Med., 2023, vol. 21, no. 1, p. 16.","journal-title":"J. Transl. Med."},{"key":"7577_CR26","doi-asserted-by":"publisher","first-page":"6581","DOI":"10.1002\/jcp.30342","volume":"236","author":"M. Ma","year":"2021","unstructured":"Ma, M., Chen, W., Hua, Y., et al., Aerobic exercise ameliorates cardiac hypertrophy by regulating mitochondrial quality control and endoplasmic reticulum stress through M(2) AChR, J. Cell Physiol., 2021, vol.\u00a0236, no. 9, pp. 6581\u20136596.","journal-title":"J. Cell Physiol."},{"key":"7577_CR27","doi-asserted-by":"publisher","first-page":"e2025932118","DOI":"10.1073\/pnas.2025932118","volume":"118","author":"C. Drake","year":"2021","unstructured":"Drake, C., Wilson, R.J., Laker, R.C., et al., Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy, Proc. Natl. Acad. Sci. U. S. A., 2021, vol. 118, no. 37, p. e2025932118.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"7577_CR28","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.yjmcc.2015.12.032","volume":"91","author":"V.G. Zaha","year":"2016","unstructured":"Zaha, V.G., Qi, D., Su, K.N., et al., AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia, J. Mol. Cell Cardiol., 2016, vol.\u00a091, pp. 104\u2013113.","journal-title":"J. Mol. Cell Cardiol."},{"key":"7577_CR29","doi-asserted-by":"publisher","first-page":"458","DOI":"10.3389\/fphar.2020.00458","volume":"11","author":"Q. Zhang","year":"2020","unstructured":"Zhang, Q., Guo, D., Wang, Y., et al., Danqi pill protects against heart failure post-acute myocardial infarction via HIF-1\u03b1\/PGC-1\u03b1 mediated glucose metabolism pathway, Front. Pharmacol., 2020, vol. 11, p. 458.","journal-title":"Front. Pharmacol."},{"key":"7577_CR30","doi-asserted-by":"publisher","first-page":"610516","DOI":"10.3389\/fcell.2020.610516","volume":"8","author":"S. Lynch","year":"2020","unstructured":"Lynch, S., Boyett, J.E., Smith, M.R., et al., Sex hormone regulation of proteins modulating mitochondrial metabolism, dynamics and inter-organellar cross talk in cardiovascular disease, Front. Cell Dev. Biol., 2020, vol. 8, p. 610516.","journal-title":"Front. Cell Dev. Biol."},{"key":"7577_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbi.2022.02.015","volume":"102","author":"J. Sun","year":"2022","unstructured":"Sun, J., Song, F.H., Wu, J.Y., et al., Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK\/PGC-1\u03b1-mediated mitochondrial biogenesis and suppression of neuroinflammation, Brain, Behav., Immun., 2022, vol. 102, pp. 53\u201370.","journal-title":"Brain, Behav., Immun."},{"key":"7577_CR32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.nbd.2018.02.004","volume":"113","author":"X. Guo","year":"2018","unstructured":"Guo, X., Jiang, Q., Tuccitto, A., et al., The AMPK-PGC-1\u03b1 signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury, Neurobiol. Dis., 2018, vol. 113, pp. 59\u201369.","journal-title":"Neurobiol. Dis."},{"key":"7577_CR33","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1093\/jpp\/rgad093","volume":"75","author":"F. Mu","year":"2023","unstructured":"Mu, F., Zhao, J., Zhao, M., et al., Liquidambar orientalis (Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1\u03b1 signaling pathway, J. Pharm. Pharmacol., 2023, vol. 75, no. 12, pp.\u00a01496\u20131508.","journal-title":"J. Pharm. Pharmacol."}],"container-title":["Doklady Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672924600556.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S1607672924600556","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672924600556.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:23:59Z","timestamp":1773761039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S1607672924600556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["7577"],"URL":"https:\/\/doi.org\/10.1134\/s1607672924600556","relation":{},"ISSN":["1607-6729","1608-3091"],"issn-type":[{"value":"1607-6729","type":"print"},{"value":"1608-3091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]},"assertion":[{"value":"15 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors of this work declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"CONFLICT OF INTEREST"}},{"value":"This work does not contain any studies involving human and animal subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"ETHICS APPROVAL AND CONSENT TO PARTICIPATE"}}]}}