{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:34:20Z","timestamp":1773772460395,"version":"3.50.1"},"reference-count":8,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Demyelinating diseases are a group of heterogeneous pathologies that affect the nervous system and reduce the quality of life. One of such diseases is multiple sclerosis (MS), an inflammatory autoimmune neurodegenerative disease of the central nervous system (CNS). At the initial stages, MS can mimic some infectious, neoplastic, genetic, metabolic, vascular, and other pathologies. Accurate differential diagnosis of this disease is important to improve the quality of life of patients and reduce possible irreversible damage to the central nervous system. In this work, we confirmed the possibility of using our previously proposed candidate panel of MS biomarkers to distinguish MS from neuromyelitis optica spectrum disorder (NMOSD) and amyotrophic lateral sclerosis (ALS). We have shown that our proposed panel (SPTAN1\n                      <jats:sub>601-644<\/jats:sub>\n                      + PRX\n                      <jats:sub>451-494<\/jats:sub>\n                      + PTK6\n                      <jats:sub>301-344<\/jats:sub>\n                      + LMP1\n                      <jats:sub>285-330<\/jats:sub>\n                      ) allows us to distinguish MS from ALS (AUC = 0.796) and NMOSD (AUC = 0.779).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1134\/s160767292460060x","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T15:31:09Z","timestamp":1731339069000},"page":"593-596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Panel of Biomarkers for Differential Diagnosis of Multiple Sclerosis"],"prefix":"10.1134","volume":"519","author":[{"given":"L. A.","family":"Ovchinnikova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Dzhelad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. O.","family":"Simaniv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Zakharova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. A.","family":"Lomakin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Gabibov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. N.","family":"Illarioshkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"137","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"7623_CR1","doi-asserted-by":"publisher","first-page":"803229","DOI":"10.3389\/fimmu.2022.803229","volume":"13","author":"Y.A. Lomakin","year":"2022","unstructured":"Lomakin, Y.A. et al., Deconvolution of B cell receptor repertoire in multiple sclerosis patients revealed a delay in tBreg maturation, Front. Immunol., 2022, vol. 13, p.\u00a0803229.","journal-title":"Front. Immunol"},{"key":"7623_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S1474-4422(22)00289-7","volume":"22","author":"T. Kuhlmann","year":"2023","unstructured":"Kuhlmann, T. et al., Multiple sclerosis progression: time for a new mechanism-driven framework, Lancet Neurol., 2023, vol. 22, no. 1, pp. 78\u201388.","journal-title":"Lancet Neurol"},{"key":"7623_CR3","first-page":"S1","volume":"55","author":"S. \u00d6merhoca","year":"2018","unstructured":"\u00d6merhoca, S., Akka\u015f, S.Y., and \u0130\u00e7en, N.K., Multiple sclerosis: diagnosis and differential diagnosis, Arch. Neuropsychiatr., 2018, vol. 55, suppl. 1, pp. S1\u2013S9.","journal-title":"Arch. Neuropsychiatr"},{"key":"7623_CR4","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","volume":"17","author":"A.J. Thompson","year":"2018","unstructured":"Thompson, A.J. et al., Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria, Lancet Neurol., 2018, vol. 17, no. 2, pp. 162\u2013173.","journal-title":"Lancet Neurol."},{"key":"7623_CR5","doi-asserted-by":"publisher","first-page":"11625","DOI":"10.1038\/s41598-023-38271-x","volume":"13","author":"J.M. Seok","year":"2023","unstructured":"Seok, J.M. et al., Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using a deep learning model, Sci. Rep., 2023, vol. 13, no. 1, p.\u00a011625.","journal-title":"Sci. Rep"},{"key":"7623_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","volume":"85","author":"D.M. Wingerchuk","year":"2015","unstructured":"Wingerchuk, D.M. et al., International consensus diagnostic criteria for neuromyelitis optica spectrum disorders, Neurology, 2015, vol. 85, no. 2, pp. 177\u2013189.","journal-title":"Neurology"},{"key":"7623_CR7","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","volume":"400","author":"E.L. Feldman","year":"2022","unstructured":"Feldman, E.L. et al., Amyotrophic lateral sclerosis, Lancet, 2022, vol. 400, no. 10360, pp. 1363\u20131380.","journal-title":"Lancet"},{"key":"7623_CR8","doi-asserted-by":"publisher","first-page":"45477","DOI":"10.1038\/srep45477","volume":"7","author":"S. Mazzara","year":"2017","unstructured":"Mazzara, S. et al., CombiROC: an interactive web tool for selecting accurate marker combinations of omics data, Sci Rep., 2017, vol. 7, p. 45477.","journal-title":"Sci Rep"}],"container-title":["Doklady Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S160767292460060X.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S160767292460060X","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S160767292460060X.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:18:33Z","timestamp":1773760713000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S160767292460060X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["7623"],"URL":"https:\/\/doi.org\/10.1134\/s160767292460060x","relation":{},"ISSN":["1607-6729","1608-3091"],"issn-type":[{"value":"1607-6729","type":"print"},{"value":"1608-3091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"30 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All studies with clinical samples were conducted in accordance with the recommendations set out in the Helsinki Declaration of the World Medical Association. The study was approved by the local ethics committee of the Scientific Center of Neurology (protocol N3-6\/20 of March 25, 2020). Written consent was obtained from all patients included in the study. All clinical samples were used in the work after their de-identification.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"ETHICS APPROVAL AND CONSENT TO PARTICIPATE"}},{"value":"The authors of this work declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"CONFLICT OF INTEREST"}}]}}