{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:32:11Z","timestamp":1773772331498,"version":"3.50.1"},"reference-count":20,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1134\/s1607672924701205","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T06:02:28Z","timestamp":1730354548000},"page":"556-563","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Features of Brain Damage after Neutron Irradiation of the Head and Modification of the Damage by Lactoferrin"],"prefix":"10.1134","volume":"519","author":[{"given":"A. V.","family":"Rodina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. V.","family":"Vysotskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Zhirnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. D.","family":"Smirnova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Parfenova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N.","family":"Strepetov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu. P.","family":"Semochkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. V.","family":"Nesterenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Yu.","family":"Moskaleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"137","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"7616_CR1","first-page":"408","volume":"60","author":"I.A. Gulidov","year":"2014","unstructured":"Gulidov, I.A. and Aslanidi, I.P., On the state and prospects of development of remote neutron therapy, Vopr. Onkol., 2014, vol. 60, no. 4, pp. 408\u2013412.","journal-title":"Vopr. Onkol."},{"key":"7616_CR2","first-page":"53","volume":"58","author":"L.I. Musabaeva","year":"2013","unstructured":"Musabaeva, L.I., Lisin, V.A., Startseva, Zh.A., Gribova, O.V., Velikaya, V.V., and Melnikov, A.A., Neutron therapy at the U-120 cyclotron. On the occasion of the 30th anniversary of the use of neutron therapy\u2014a review of the results of scientific research, Med. Radiol. Radiats. Bezop., 2013, vol. 58, no. 2, pp. 53\u201361.","journal-title":"Med. Radiol. Radiats. Bezop."},{"key":"7616_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.33266\/1024-6177-2022-67-5","volume":"67","author":"V.V. Velikaya","year":"2022","unstructured":"Velikaya, V.V., Startseva, Zh.A., Lisin, V.A., Goldberg, V.E., and Popova, N.O., Adjuvant neutron therapy in combined modality treatment of patients with primary-metastatic breast cancer, Med. Radiol. Radiats. Bezop., 2022, vol. 67, no. 5, pp. 64\u201368. https:\/\/doi.org\/10.33266\/1024-6177-2022-67-5","journal-title":"Med. Radiol. Radiats. Bezop."},{"key":"7616_CR4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.21294\/1814-4861-2016-15-3","volume":"15","author":"L.I. Musabaeva","year":"2016","unstructured":"Musabaeva, L.I., Choinzonov, E.L., Gribova, O.V., Startseva, Zh.A., Velikaya, V.V., and Lisin, V.A., Neutron therapy in the treatment of radioresistant malignant tumors, Sib. Onkol. Zh., 2016, vol. 15, no. 3, pp.\u00a067\u201371. https:\/\/doi.org\/10.21294\/1814-4861-2016-15-3","journal-title":"Sib. Onkol. Zh."},{"key":"7616_CR5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fonc.2016.00030","volume":"6","author":"S. Walenta","year":"2016","unstructured":"Walenta, S. and Mueller-Klieser, W., Differential superiority of heavy charged-particle irradiation to X-rays: studies on biological effectiveness and side effect mechanisms in multicellular tumor and normal tissue models, Front. Oncol., 2016, vol. 6, p. 30. https:\/\/doi.org\/10.3389\/fonc.2016.00030","journal-title":"Front. Oncol."},{"key":"7616_CR6","first-page":"261","volume":"52","author":"O.N. Matchuk","year":"2012","unstructured":"Matchuk, O.N., Zamulaeva, I.A., Selivanova, E.I., Lipunov, N.M., Proniushkina, K.A., Ul\u2019ianenko, S.E., Lychagin, A.A., Smirnova, S.G., Orlova, N.V., Saenko, A.S., et al., Sensitivity of melanoma B16 side population to low- and high-LET radiation, Radiats. Biol. Radioekol., 2012, vol. 52, no. 3, pp. 261\u2013267.","journal-title":"Radiats. Biol. Radioekol."},{"key":"7616_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.20517\/2394-4722.2022.29","volume":"8","author":"V.G. Shuvatova","year":"2022","unstructured":"Shuvatova, V.G., Semochkina, Yu.P., Strepetov, A.N., and Moskaleva, E.Y., Sensitivity of MCF-7 mammosphere CSCs to neutron radiation, J. Cancer Metastasis Treat., 2022, vol. 8, no. 5, p. 23. https:\/\/doi.org\/10.20517\/2394-4722.2022.29","journal-title":"J. Cancer Metastasis Treat."},{"key":"7616_CR8","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1007\/s12035-015-9628-x","volume":"54","author":"L. Yang","year":"2017","unstructured":"Yang, L., Yang, J., Li, G., Li, Yi., Wu, R., Cheng, J., and Tang, Ya., Pathophysiological responses in rat and mouse models of radiation-induced brain injury, Mol. Neurobiol., 2017, vol. 54, no. 2, pp. 1022\u20131032. https:\/\/doi.org\/10.1007\/s12035-015-9628-x","journal-title":"Mol. Neurobiol."},{"key":"7616_CR9","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s11481-013-9434-z","volume":"8","author":"U.B. Eyo","year":"2013","unstructured":"Eyo, U.B. and Dailey, M.E., Microglia: key elements in neural development, plasticity, and pathology, J. Neuroimmune Pharmacol., 2013, vol. 8, no. 3, pp. 494\u2013509. https:\/\/doi.org\/10.1007\/s11481-013-9434-z","journal-title":"J. Neuroimmune Pharmacol."},{"key":"7616_CR10","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/ijms18030504","volume":"18","author":"K.K. Thompson","year":"2017","unstructured":"Thompson, K.K. and Tsirka, S.E., The diverse roles of microglia in the neurodegenerative aspects of central nervous system (CNS) autoimmunity, Int. J. Mol. Sci., 2017, vol. 18, no. 3, p. 504. https:\/\/doi.org\/10.3390\/ijms18030504","journal-title":"Int. J. Mol. Sci."},{"key":"7616_CR11","doi-asserted-by":"publisher","first-page":"19382","DOI":"10.18632\/oncotarget.8400","volume":"7","author":"M. Kalm","year":"2016","unstructured":"Kalm, M., Andreasson, U., Bj\u00f6rk-Eriksson, T., Zetterberg, H., Pekny, M., Blennow, K., Pekna, M., and Blomgren, K., C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning, Oncotarget, 2016, vol. 7, no. 15, pp. 19382\u201319394. https:\/\/doi.org\/10.18632\/oncotarget.8400","journal-title":"Oncotarget"},{"key":"7616_CR12","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1080\/09553002.2021.1928787","volume":"97","author":"A.V. Rodina","year":"2021","unstructured":"Rodina, A.V., Semochkina, Yu.P., Vysotskaya, O.V., Romantsova, A.N., Strepetov, A.N., and Moskaleva,\u00a0E.Y., Low dose gamma irradiation pretreatment modulates the sensitivity of CNS to subsequent mixed gamma and neutron irradiation of the mouse head, Int. J. Radiat. Biol., 2021, vol. 97, no. 7, pp. 926\u2013942. https:\/\/doi.org\/10.1080\/09553002.2021.1928787","journal-title":"Int. J. Radiat. Biol."},{"key":"7616_CR13","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.3892\/etm.2018.6570","volume":"16","author":"L. Feng","year":"2018","unstructured":"Feng, L., Li, J., Qin, L., Guo, D., Ding, H., and Deng, D., Radioprotective effect of lactoferrin in mice exposed to sublethal X\u2011ray irradiation, Exp. Ther. Med., 2018, vol. 16, no. 4, pp. 3143\u20133148. https:\/\/doi.org\/10.3892\/etm.2018.6570","journal-title":"Exp. Ther. Med."},{"key":"7616_CR14","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.3390\/antiox11091833","volume":"11","author":"M.Y. Kopaeva","year":"2022","unstructured":"Kopaeva, M.Y., Alchinova, I.B., Cherepov, A.B., Demorzhi, M.S., Nesterenko, M.V., Zarayskaya, I.Y., and Karganov, M.Y., New properties of a well-known antioxidant: pleiotropic effects of human lactoferrin in mice exposed to gamma irradiation in a sublethal dose, Antioxidants (Basel), 2022, vol. 11, no. 9, p. 1833. https:\/\/doi.org\/10.3390\/antiox11091833","journal-title":"Antioxidants"},{"key":"7616_CR15","unstructured":"Ivanov, A.A., Ulanova, A.M., Deshevoi, Yu.B., and Mal\u2019tsev, V.N., A treatment for radiation sickness, RF\u00a0Patent no. 2294755, Byull. Izobret., 2007, no. 7."},{"key":"7616_CR16","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1134\/s1063784218100031","volume":"63","author":"S.S. Arzumanov","year":"2018","unstructured":"Arzumanov, S.S., Safronov, V.V., and Strepetov, A.N., Determination of a dose absorbed in a biological sample under mixed gamma\u2013neutron irradiation, Tech. Phys., 2018, vol. 63, no. 10, pp. 1533\u20131536. https:\/\/doi.org\/10.1134\/s1063784218100031","journal-title":"Tech. Phys."},{"key":"7616_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.31857\/S0869803121010112","volume":"61","author":"A.S. Zhirnik","year":"2021","unstructured":"Zhirnik, A.S., Smirnova, O.D., Semochkina, Yu., Shibaeva, K.D., Rodina, A.V., Ratushnyak, M.G., and Moskaleva, E.Yu., Cognitive impairment and induction of neuroinflammation in the late period after single whole brain \u03b3-irradiation of mice, Radiats. Biol. Radioekol., 2021, vol. 61, no. 1, pp. 32\u201343. https:\/\/doi.org\/10.31857\/S0869803121010112","journal-title":"Radiats. Biol. Radioekol."},{"key":"7616_CR18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.33266\/1024-6177-2022-67-5-10","volume":"67","author":"A.S. Zhirnik","year":"2022","unstructured":"Zhirnik, A.S., Rodina, A.V., Semochkina, Yu.P., Vysotskaya, O.V., Smirnova, O.D., Ratushnyak, M.G., and Moskaleva, E.Yu., Cognitive disturbances and the state of brain glial cells in mice exposed to fractionated whole-brain irradiation, Med. Radiol. Radiats. Bezop., 2022, vol. 67, no. 5, pp. 10\u201317. https:\/\/doi.org\/10.33266\/1024-6177-2022-67-5-10","journal-title":"Med. Radiol. Radiats. Bezop."},{"key":"7616_CR19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1134\/S0041377119100067","volume":"61","author":"G.A. Posypanova","year":"2019","unstructured":"Posypanova, G.A., Ratushnyak, M.G., Semochkina, Y.P., Abisheva, A.A., and Moskaleva, E.Yu., The sensitivity of the cultured murine neural stem cells to the ionizing radiation, Tsitologiya, 2019, vol. 61, no. 10, pp. 806\u2013816.","journal-title":"Tsitologiya"},{"key":"7616_CR20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.7868\/S0869803117030018","volume":"57","author":"E.Yu. Moskaleva","year":"2017","unstructured":"Moskaleva, E.Yu., Semochkina, Y.P., Rodina, A.V., Chukalova, A.A., and Posypanova, G.A., Effects of \u03b3-radiation on mesenchymal stem cells from mouse bone marrow and brain and their ability to induce tumors, Radiats. Biol. Radioekol., 2017, vol. 57, no. 3, pp.\u00a0245\u2013256.","journal-title":"Radiats. Biol. Radioekol."}],"container-title":["Doklady Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672924701205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S1607672924701205","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672924701205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:16:41Z","timestamp":1773760601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S1607672924701205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["7616"],"URL":"https:\/\/doi.org\/10.1134\/s1607672924701205","relation":{},"ISSN":["1607-6729","1608-3091"],"issn-type":[{"value":"1607-6729","type":"print"},{"value":"1608-3091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"20 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All applicable national guidelines for the care and use of animals were followed. All animal experiments were conducted in accordance with the requirements of the Ethics Committee of the Kurchatov Institute Research Center (Protocol no. NG-1\/109PR dated February 13, 2020).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"ETHICS APPROVAL AND CONSENT TO PARTICIPATE"}},{"value":"The authors of this work declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"CONFLICT OF INTEREST"}}]}}