{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:32:05Z","timestamp":1773772325601,"version":"3.50.1"},"reference-count":30,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1134\/s1607672925700115","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T10:28:41Z","timestamp":1747045721000},"page":"352-357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relation of Cytokine Profile and Antibody Values to Post-Translational Protein Modifications in Patients with Rheumatoid Arthritis (Preliminary Data)"],"prefix":"10.1134","volume":"522","author":[{"given":"D. A.","family":"Dibrov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Avdeeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Diatroptov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. V.","family":"Rybakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. L.","family":"Nasonov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"137","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"7687_CR1","doi-asserted-by":"publisher","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","volume":"4","author":"J.S. Smolen","year":"2018","unstructured":"Smolen, J.S., Aletaha, D., Barton, A., Burmester, G.R., Emery, P., Firestein, G.S., Kavanaugh, A., et al., Rheumatoid arthritis, Nat. Rev. Dis. Primers, 2018, vol.\u00a04, p. 18001.","journal-title":"Nat. Rev. Dis. Primers"},{"key":"7687_CR2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.47360\/1995-4484-2023-276-291","volume":"61","author":"E.L. Nasonov","year":"2023","unstructured":"Nasonov, E.L., Avdeeva, A.S., and Dibrov, D.A., Rheumatoid arthritis as a clinical and immunological syndrome: focus on the seronegative subtype of the disease, Rheumatol. Sci. Pract., 2023, vol. 61, no. 3, pp.\u00a0276\u2013291.","journal-title":"Rheumatol. Sci. Pract."},{"key":"7687_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMra2103726","volume":"388","author":"E.M. Gravallese","year":"2023","unstructured":"Gravallese, E.M. and Firestein, G.S., Rheumatoid arthritis\u2014Common origins, divergent mechanisms, N. Engl. J. Med., 2023, vol. 388, no. 6, pp. 529\u2013542.","journal-title":"N. Engl. J. Med."},{"key":"7687_CR4","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.autrev.2018.06.001","volume":"17","author":"D. McGonagle","year":"2018","unstructured":"McGonagle, D., Watad, A., and Savic, S., Mechanistic immunological based classification of rheumatoid arthritis, Autoimmun. Rev., 2018, vol. 17, no. 11, pp. 1115\u20131123.","journal-title":"Autoimmun. Rev."},{"key":"7687_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nrrheum.2015.171","volume":"12","author":"I.B. McInnes","year":"2016","unstructured":"McInnes, I.B., Buckley, C.D., and Isaacs, J.D., Cytokines in rheumatoid arthritis\u2014shaping the immunological landscape, Nat. Rev. Rheumatol., 2016, vol. 12, no.\u00a01, pp. 63\u201368.","journal-title":"Nat. Rev. Rheumatol."},{"key":"7687_CR6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1136\/annrheumdis-2017-211555","volume":"77","author":"K.F. Baker","year":"2018","unstructured":"Baker, K.F. and Isaacs, J.D., Novel therapies for immune-mediated inflammatory diseases: what can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn\u2019s disease and ulcerative colitis?, Ann. Rheum. Dis., 2018, vol. 77, no. 2, pp. 175\u2013187.","journal-title":"Ann. Rheum. Dis."},{"key":"7687_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.14412\/1995-4484-2017-409-419","volume":"55","author":"E.L. Nasonov","year":"2017","unstructured":"Nasonov, E.L., Pharmacotherapy for rheumatoid arthritis: new strategy, new targets, Rheumatol. Sci. Pract., 2017, vol. 55, no. 4, pp. 409\u2013419.","journal-title":"Rheumatol. Sci. Pract."},{"key":"7687_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.47360\/1995-4484-2023-397-420","volume":"61","author":"E.L. Nasonov","year":"2023","unstructured":"Nasonov, E.L., Modern concept of autoimmunity in rheumatology, Rheumatol. Sci. Pract., 2023, vol. 61, no.\u00a04, pp. 397\u2013420.","journal-title":"Rheumatol. Sci. Pract."},{"key":"7687_CR9","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D. Aletaha","year":"2010","unstructured":"Aletaha, D., Neogi, T., Silman, A.J., Funovits, J., Felson, D.T., Bingham, C.O., Birnbaum, N.S., Burmester, G.R., Bykerk, V.P., Cohen, M.D., Combe, B., Costenbader, K.H., Dougados, M., Emery, P., Ferraccioli, G., Hazes, J.M.W., Hobbs, K., Huizinga, T.W.J., Kavanaugh, A., Kay, J., Kvien, T.K., Laing, T., Mease, P., M\u00e9nard, H.A., Moreland, L.W., Naden, R.L., Pincus, T., Smolen, J.S., Stanislawska-biernat, E., Symmons, D., Tak, P.P., Upchurch, K.S., Vencovsk\u00fd, J., Wolfe, F., and Hawker, G., 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative, Arthritis Rheum., 2010, vol. 62, no. 9, pp.\u00a02569\u20132581. https:\/\/doi.org\/10.1002\/art.27584","journal-title":"Arthritis Rheum."},{"key":"7687_CR10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"M.L. Prevoo","year":"1995","unstructured":"Prevoo, M.L., van \u2019t Hof, M.A., Kuper, H.H., Van\u00a0Leeuwen, M.A., et al., Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis, Arthritis Rheum., 1995, vol. 38, no. 1, pp. 44\u201348.","journal-title":"Arthritis Rheum."},{"key":"7687_CR11","doi-asserted-by":"publisher","first-page":"10922","DOI":"10.3390\/ijms222010922","volume":"22","author":"N. Kondo","year":"2021","unstructured":"Kondo, N., Kuroda, T., and Kobayashi, D., Cytokine networks in the pathogenesis of rheumatoid arthritis, Int. J. Mol. Sci., 2021, vol. 22, no. 20, p. 10922.","journal-title":"Int. J. Mol. Sci."},{"key":"7687_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.14412\/1995-4484-2010-1420","volume":"48","author":"A.A. Novikov","year":"2010","unstructured":"Novikov, A.A., Aleksandrova, E.N., Diatroptova, M.A., and Nasonov, E.L., Role of cytokines in the pathogenesis of rheumatoid arthritis, Rheumatol. Sci. Pract., 2010, vol. 48, no. 2, pp. 71\u201382.","journal-title":"Rheumatol. Sci. Pract."},{"key":"7687_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/cei.12677","volume":"182","author":"Z. Reyes-Castillo","year":"2015","unstructured":"Reyes-Castillo, Z., Palafox-S\u00e1nchez, C.A., Parra-Rojas, I., Mart\u00ednez-Bonilla, G.E., et al., Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features, Clin. Exp. Immunol., 2015, vol. 182, no. 2, pp.\u00a0119\u2013131.","journal-title":"Clin. Exp. Immunol."},{"key":"7687_CR14","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1007\/s10067-019-04681-4","volume":"38","author":"R.-P.I. S\u00e1nchez-Hern\u00e1ndez","year":"2019","unstructured":"S\u00e1nchez-Hern\u00e1ndez, R.-P.I., E, P., Valle, M., F, J., Mart\u00ednez-Bonilla, G.E., et al., Cytokines (IL-15, IL-21, and IFN-\u03b3) in rheumatoid arthritis: association with positivity to autoantibodies (RF, anti-CCP, anti-MCV, and anti-PADI4) and clinical activity, Clin. Rheumatol., 2019, vol. 38, no. 11, pp. 3061\u20133071.","journal-title":"Clin. Rheumatol."},{"key":"7687_CR15","doi-asserted-by":"crossref","unstructured":"Meyer, P.W., Hodkinson, B., Ally, M., Musenge, E., et\u00a0al., Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis, Mediators Inflamm., 2010, vol. 2010, p. 158514.","DOI":"10.1155\/2010\/158514"},{"key":"7687_CR16","first-page":"2336","volume":"31","author":"C.A. Hitchon","year":"2004","unstructured":"Hitchon, C.A., Alex, P., Erdile, L.B., Frank, M.B., et\u00a0al., A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis, J. Rheumatol., 2004, vol. 31, no. 12, pp. 2336\u20132346.","journal-title":"J. Rheumatol."},{"key":"7687_CR17","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1136\/ard.2006.054924","volume":"66","author":"W. Hueber","year":"2007","unstructured":"Hueber, W., Tomooka, B.H., Zhao, X., Kidd, B.A., et\u00a0al., Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines, Ann. Rheum. Dis., 2007, vol. 66, no. 6, pp. 712\u2013719.","journal-title":"Ann. Rheum. Dis."},{"key":"7687_CR18","doi-asserted-by":"publisher","first-page":"393","DOI":"10.18786\/2072-0505-2019-47-058","volume":"47","author":"A.A. Novikov","year":"2019","unstructured":"Novikov, A.A., Aleksandrova, E.N., and Lukina, G.V., Serum cytokine profile in early and established rheumatoid arthritis, Almanac Clin. Med., 2019, vol. 47, no.\u00a05, pp. 393\u2013399.","journal-title":"Almanac Clin. Med."},{"key":"7687_CR19","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/art.27186","volume":"62","author":"H. Kokkonen","year":"2010","unstructured":"Kokkonen, H., S\u00f6derstr\u00f6m, I., Rockl\u00f6v, J., and Hallmans, G., Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis, Arthritis Rheum., 2010, vol. 62, no. 2, pp. 383\u2013391.","journal-title":"Arthritis Rheum."},{"key":"7687_CR20","doi-asserted-by":"crossref","unstructured":"Sokolove, J., Bromberg, R., Deane, K.D., Lahey, L.J., et al., Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis, PLoS One, 2012, vol. 7, no. 5, p. e35296.","DOI":"10.1371\/journal.pone.0035296"},{"key":"7687_CR21","doi-asserted-by":"publisher","first-page":"10922","DOI":"10.3390\/ijms222010922","volume":"22","author":"N. Kondo","year":"2021","unstructured":"Kondo, N., Kuroda, T., and Kobayashi, D., Cytokine networks in the pathogenesis of rheumatoid arthritis, Int. J. Mol. Sci., 2021, vol. 22, no. 20, p. 10922.","journal-title":"Int. J. Mol. Sci."},{"key":"7687_CR22","doi-asserted-by":"publisher","first-page":"11596","DOI":"10.1038\/ncomms11596","volume":"7","author":"Z. Chen","year":"2016","unstructured":"Chen, Z., Andreev, D., Oeser, K., Krljanac, B., et al., Th2 and eosinophil responses suppress inflammatory arthritis, Nat. Commun., 2016, vol. 7, p. 11596.","journal-title":"Nat. Commun."},{"key":"7687_CR23","doi-asserted-by":"crossref","unstructured":"Pan, Q., Walls, A.F., and Pan, Q., Editorial: Th2-associated immunity in the pathogenesis of systemic lupus erythematosus and rheumatoid arthritis, Front. Immunol., 2022, vol. 13, p. 975553.","DOI":"10.3389\/fimmu.2022.975553"},{"key":"7687_CR24","doi-asserted-by":"publisher","first-page":"165","DOI":"10.47360\/1995-4484-2023-165-180","volume":"61","author":"E.L. Nasonov","year":"2023","unstructured":"Nasonov, E.L., Avdeeva, A.S., Korotaeva, T.V., Dubinina, T.V., and Usacheva, J.V., The role of interleukin 17 in the pathogenesis of rheumatoid arthritis. Are there any prospects for the use of IL-17 inhibitors?, Rheumatol. Sci. Pract., 2023, vol. 61, no. 2, pp. 165\u2013180.","journal-title":"Rheumatol. Sci. Pract."},{"key":"7687_CR25","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/s13075-014-0426-z","volume":"16","author":"L.G. Van Baarsen","year":"2014","unstructured":"Van Baarsen, L.G., Lebre, M.C., van der Coelen, D., Aarrass, S., et al., Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?, Arthritis Res. Ther., 2014, vol. 16, no. 4, p. 426.","journal-title":"Arthritis Res. Ther."},{"key":"7687_CR26","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s40744-021-00407-8","volume":"9","author":"P.J. Mease","year":"2022","unstructured":"Mease, P.J., Bhutani, M.K., Hass, S., Yi, E., et al., Comparison of clinical manifestations in rheumatoid arthritis vs. spondyloarthritis: a systematic literature review, Rheumatol. Ther., 2022, vol. 9, no. 2, pp. 331\u2013378.","journal-title":"Rheumatol. Ther."},{"key":"7687_CR27","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3389\/fmed.2018.00364","volume":"5","author":"M. Robert","year":"2019","unstructured":"Robert, M. and Miossec, P., IL-17 in rheumatoid arthritis and precision medicine: from synovitis expression to circulating bioactive levels, Front. Med. (Lausanne), 2019, vol. 5, p. 364.","journal-title":"Front. Med."},{"key":"7687_CR28","doi-asserted-by":"crossref","unstructured":"Gremese, E., Tolusso, B., Bruno, D., Perniola, S., et\u00a0al., The forgotten key players in rheumatoid arthritis: IL-8 and IL-17\u2014Unmet needs and therapeutic perspectives, Front. Med. (Lausanne), 2023, vol. 10, p.\u00a0956127.","DOI":"10.3389\/fmed.2023.956127"},{"key":"7687_CR29","doi-asserted-by":"crossref","unstructured":"Merola, J.F., Espinoza, L.R., and Fleischmann, R., Distinguishing rheumatoid arthritis from psoriatic arthritis, RMD Open, 2018, vol. 4, no. 2, p. e000656.","DOI":"10.1136\/rmdopen-2018-000656"},{"key":"7687_CR30","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1093\/rheumatology\/kez147","volume":"58","author":"S. McDonald","year":"2019","unstructured":"McDonald, S., Reed, R., Baricevic-Jones, I., Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, et al., Can serum interleukin-17 and interleukin-10 levels predict response to biologic treatments in patients with rheumatoid arthritis?, Rheumatology (Oxford), 2019, vol. 58, no. 10, pp. 1872\u20131873.","journal-title":"Rheumatology"}],"container-title":["Doklady Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672925700115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S1607672925700115","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672925700115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:16:40Z","timestamp":1773760600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S1607672925700115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["7687"],"URL":"https:\/\/doi.org\/10.1134\/s1607672925700115","relation":{},"ISSN":["1607-6729","1608-3091"],"issn-type":[{"value":"1607-6729","type":"print"},{"value":"1608-3091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,11]]},"assertion":[{"value":"2 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the local ethics committee (protocol no. 22 dated December 2, 2021). All patients signed voluntary informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"ETHICS APPROVAL AND CONSENT TO PARTICIPATE"}},{"value":"The authors of this work declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"CONFLICT OF INTEREST"}}]}}