{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:34:02Z","timestamp":1791326042818,"version":"4.3.1"},"reference-count":20,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1134\/s1607672925700140","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T10:28:39Z","timestamp":1747045719000},"page":"387-403","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Efficacy and Safety of BCD-180, an Anti-TRBV9+ T cell Monoclonal Antibody, in Patients with Active Radiographic Axial Spondyloarthritis: 36-week Results from the Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study ELEFTA"],"prefix":"10.1134","volume":"522","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-8360","authenticated-orcid":false,"given":"E. L.","family":"Nasonov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-2051","authenticated-orcid":false,"given":"V. I.","family":"Mazurov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6068-3080","authenticated-orcid":false,"given":"A. M.","family":"Lila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-6246","authenticated-orcid":false,"given":"T. V.","family":"Dubinina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-7256","authenticated-orcid":false,"given":"I. Z.","family":"Gaidukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-8565","authenticated-orcid":false,"given":"S. A.","family":"Lapshina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-9784","authenticated-orcid":false,"given":"A. A.","family":"Klimenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-3663","authenticated-orcid":false,"given":"D. V.","family":"Somov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-2402","authenticated-orcid":false,"given":"S. A.","family":"Lukyanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0430-790X","authenticated-orcid":false,"given":"D. M.","family":"Chudakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-9116","authenticated-orcid":false,"given":"I. V.","family":"Zvyagin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-1392","authenticated-orcid":false,"given":"O. V.","family":"Britanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-0847","authenticated-orcid":false,"given":"M. A.","family":"Korolev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-2725","authenticated-orcid":false,"given":"D. I.","family":"Abdulganieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-6144","authenticated-orcid":false,"given":"D. G.","family":"Krechikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1170-8691","authenticated-orcid":false,"given":"A. A.","family":"Kastanayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-3321","authenticated-orcid":false,"given":"L. V.","family":"Eliseeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-3334","authenticated-orcid":false,"given":"R. R.","family":"Samigullina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-6769","authenticated-orcid":false,"given":"T. V.","family":"Povarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-4034","authenticated-orcid":false,"given":"O. V.","family":"Antipova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-4263","authenticated-orcid":false,"given":"S. A.","family":"Smakotina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7794-3190","authenticated-orcid":false,"given":"V. N.","family":"Soboleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-8248","authenticated-orcid":false,"given":"O. B.","family":"Nesmeyanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-1752","authenticated-orcid":false,"given":"T. V.","family":"Plaksina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-2965","authenticated-orcid":false,"given":"N. F.","family":"Soroka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-912X","authenticated-orcid":false,"given":"I. B.","family":"Vinogradova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-7734","authenticated-orcid":false,"given":"A. P.","family":"Rebrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-8646","authenticated-orcid":false,"given":"T. V.","family":"Kropotina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-4148","authenticated-orcid":false,"given":"A. L.","family":"Maslyansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-2232","authenticated-orcid":false,"given":"A. V.","family":"Zinkina-Orikhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-1022","authenticated-orcid":false,"given":"Yu. N.","family":"Linkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-8207","authenticated-orcid":false,"given":"P. S.","family":"Pukhtinskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-7526","authenticated-orcid":false,"given":"M. A.","family":"Morozova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3025-198X","authenticated-orcid":false,"given":"G. A.","family":"Vinderskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"137","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"7685_CR1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.14412\/1995-4484-2015-657-660","volume":"53","author":"Sh.F. Erdes","year":"2015","unstructured":"Erdes, Sh.F., Badokin, V.V., Bochkova, A.G., Bugrova, O.V., Gaidukova, I.Z., Godzenko, A.A., Dubikov, A.A., Dubinina, T.V., Ivanova, O.N., Korotaeva, T.V., Lapshina, S.A., Nesmeyanova, O.B., Nikishina, I.P., Otteva, E.N., Raskina, T.A., Rebrov, A.P., Rumyantseva, O.A., Sitalo, A.V., and Smirnov, A.V., On the terminology of spondyloarthritis, Rheumatol. Sci. Pract., 2015, vol. 53, no. 6, pp. 657\u2013660. https:\/\/doi.org\/10.14412\/1995-4484-2015-657-660","journal-title":"Rheumatol. Sci. Pract."},{"key":"7685_CR2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/rheumatology\/kew367","volume":"56","author":"X. Baraliakos","year":"2017","unstructured":"Baraliakos, X., Kiltz, U., Peters, S., Appel, H., Dybowski, F., Igelmann, M., Kalthoff, L., Krause, D., Menne, H.-J., Saracbasi-Zender, E., Schmitz-Bortz, E., Vigneswaran, M., and Braun, J., Efficiency of treatment with non-steroidal anti-inflammatory drugs according to current recommendations in patients with radiographic and non-radiographic axial spondyloarthritis, Rheumatology (Oxford), 2017, vol. 56, no. 1, pp.\u00a095\u2013102. https:\/\/doi.org\/10.1093\/rheumatology\/kew367","journal-title":"Rheumatology"},{"key":"7685_CR3","doi-asserted-by":"crossref","unstructured":"Fragoulis, G.E. and Siebert, S., Treatment strategies in axial spondyloarthritis: what, when and how?, Rheumatology (Oxford), 2020, vol. 59, no. suppl. 4, pp.\u00a0iv79\u2013iv89.","DOI":"10.1093\/rheumatology\/keaa435"},{"key":"7685_CR4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/ard-2022-223296","volume":"82","author":"S. Ramiro","year":"2023","unstructured":"Ramiro, S., Nikiphorou, E., Sepriano, A., Ortolan, A., Webers, C., and Baraliakos, X., ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update, Ann. Rheum. Dis., 2023, vol. 82, no. 1, pp. 19\u201334.","journal-title":"Ann. Rheum. Dis."},{"key":"7685_CR5","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s40744-023-00586-6","volume":"10","author":"J.A. Walsh","year":"2023","unstructured":"Walsh, J.A., Saffore, C.D., Collins, E.B., and Ostor, A., Clinical and economic benefit of advanced therapies for the treatment of active ankylosing spondylitis, Rheumatol. Ther., 2023, vol. 10, no. 5, pp. 1385\u20131398.","journal-title":"Rheumatol. Ther."},{"key":"7685_CR6","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1007\/s12325-022-02064-x","volume":"39","author":"X. Juanola","year":"2022","unstructured":"Juanola, X., Ramos, M., Belzunegui, J.M., Fem\u03acndez-Carballido, C., and Gratacos, J., Treatment failure in axial spondyloarthritis: insights for a standardized definition, Adv. Ther., 2022, vol. 39, no. 4, pp. 1490\u20131501.","journal-title":"Adv. Ther."},{"key":"7685_CR7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.semarthrit.2017.04.005","volume":"47","author":"A. Deodhar","year":"2017","unstructured":"Deodhar, A. and Yu, D., Switching tumor necrosis factor inhibitors in the treatment of axial spondyloarthritis, Semin. Arthritis Rheum., 2017, vol. 47, no. 3, pp.\u00a0343\u2013350.","journal-title":"Semin. Arthritis Rheum."},{"key":"7685_CR8","doi-asserted-by":"publisher","first-page":"6463","DOI":"10.3390\/ijms24076463","volume":"24","author":"S. Del Vescovo","year":"2023","unstructured":"Del Vescovo, S., Venerito, V., Iannone, C., and Lopalco, G., Uncovering the underworld of axial spondyloarthritis, Int. J. Mol. Sci., 2023, vol. 24, no. 7, p. 6463. https:\/\/doi.org\/10.3390\/ijms24076463","journal-title":"Int. J. Mol. Sci."},{"key":"7685_CR9","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s11926-022-01090-6","volume":"24","author":"J. Garrido-Mesa","year":"2022","unstructured":"Garrido-Mesa, J. and Brown, M.A., T cell repertoire profiling and the mechanism by which HLA-B27 causes ankylosing spondylitis, Curr. Rheumatol. Rep., 2022, vol. 24, no. 12, pp. 398\u2013410.","journal-title":"Curr. Rheumatol. Rep."},{"key":"7685_CR10","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1093\/rheumatology\/kex517","volume":"57","author":"E.A. Komech","year":"2018","unstructured":"Komech, E.A., Pogorelyy, M.V., Egorov, E.S., Britanova, O.V., Rebrikov, D.V., and Bochkova, A.G., CD8\u00a0+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients, Rheumatology (Oxford), 2018, vol. 57, no. 6, pp. 1097\u20131104.","journal-title":"Rheumatology"},{"key":"7685_CR11","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/art.40028","volume":"69","author":"M. Faham","year":"2017","unstructured":"Faham, M., Carlton, V., Moorhead, M., Zheng, J., Klinger, M., and Pepin, F., Discovery of T cell receptor \u03b2 motifs specific to HLA-B27-positive ankylosing spondylitis by deep repertoire sequence analysis, Arthritis Rheumatol., 2017, vol. 69, no. 4, pp. 774\u2013784.","journal-title":"Arthritis Rheumatol."},{"key":"7685_CR12","doi-asserted-by":"crossref","unstructured":"Komech, E.A., Koltakova, A.D., Barinova, A.A., Minervina, A.A., Salnikova, M.A., and Shmidt, E.I., TCR repertoire profiling revealed antigen-driven CD8\u00a0+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis, Front. Immunol., 2022, vol. 13, p. 973243.","DOI":"10.3389\/fimmu.2022.973243"},{"key":"7685_CR13","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/s41586-022-05501-7","volume":"612","author":"X. Yang","year":"2022","unstructured":"Yang, X., Garner, L.I., Zvyagin, I.V., Paley, M.A., Komech, E.A., Jude, K.M., Zhao, X., Fernandes, R.A., Hassman, L.M., Paley, G.L., Savvides, Ch.S., Brackenridge, S., Quastel, M.N., Chudakov, D.M., Bowness, P., Yokoyama, W.M., Mcmichael, A.J., Gillespie, G.M., and Garcia, K.Ch., Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides, Nature, 2022, vol. 612, no. 7941, pp. 771\u2013777. https:\/\/doi.org\/10.1038\/s41586-022-05501-7","journal-title":"Nature"},{"key":"7685_CR14","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1038\/s41591-023-02613-z","volume":"29","author":"O.V. Britanova","year":"2023","unstructured":"Britanova, O.V., Lupyr, K.R., Staroverov, D.B., Shagina, I.A., Aleksandrov, A.A., Ustyugov, Y.Y., et al., Targeted depletion of TRBV9(+) T cells as immunotherapy in a patient with ankylosing spondylitis, Nat. Med., 2023, vol. 29, no. 11, pp. 2731\u20132736.","journal-title":"Nat. Med."},{"key":"7685_CR15","doi-asserted-by":"publisher","unstructured":"Israelson, M.A., Stepanov, A.V., Staroverov, D.B., Shagina, I.A., Misorin, A.K., Evstratieva, A.V., Merzlyak, E.M., Bogdanova, E.A., Britanova, O.V., and Lukyanov, S.A., Testing of monoclonal antibodies against the T-cell receptor associated with ankylosing spondylitis, Bull. Russ. State Med. Univ., 2018, no.\u00a052018, pp. 71\u201379. https:\/\/doi.org\/10.24075\/brsmu.2018.064","DOI":"10.24075\/brsmu.2018.064"},{"key":"7685_CR16","unstructured":"European Medicines Agency, Guideline on the clinical investigation of medicinal products for the treatment of axial spondyloarthritis. EMA\/CPMP\/EWP\/4891\/03 Rev. 1, Corr. 1, 2017. \nhttps:\/\/www.ema.europa.eu\/en\/clinical-investigation- medicinal-products-treatment-axial-spondyloarthritis#current-effective-version-section. Accessed December 24, 2021."},{"key":"7685_CR17","doi-asserted-by":"crossref","unstructured":"Sieper, J., Rudwaleit, M., Baraliakos, X., Brandt, J., Braun, J., and Burgos-Vargas, R., The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis, Ann. Rheum. Dis., 2009, vol. 68, no. suppl. 2, pp. ii1\u2013ii44.","DOI":"10.1136\/ard.2008.104018"},{"key":"7685_CR18","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/art.21337","volume":"53","author":"W.P. Maksymowych","year":"2005","unstructured":"Maksymowych, W.P., Inman, R.D., Salonen, D., Dhillon, S.S., Krishnananthan, R., and Stone, M., Spondyloarthritis Research Consortium of Canada magnetic resonance imaging index for assessment of spinal inflammation in ankylosing spondylitis, Arthritis Rheum., 2005, vol. 53, no. 4, pp. 502\u2013509.","journal-title":"Arthritis Rheum."},{"key":"7685_CR19","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1136\/ard.2008.100826","volume":"68","author":"D. van der Heijde","year":"2009","unstructured":"van der Heijde, D., Lie, E., Kvien, T.K., Sieper, J., van den Bosch, F., Listing, J., et al., ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis, Ann. Rheum. Dis., 2009, vol. 68, no. 12, pp. 1811\u20131818.","journal-title":"Ann. Rheum. Dis."},{"key":"7685_CR20","first-page":"47","volume":"87","author":"I.Z. Gaidukova","year":"2015","unstructured":"Gaidukova, I.Z., Rebrov, A.P., and Poddubny, D.A., Efficacy and safety of intravenous methylprednisolone for the treatment of patients with active ankylosing spondylitis: results of a 12-week open-label pilot study (METALL), Ther. Arch., 2015, vol. 87, no. 5, pp. 47\u201352.","journal-title":"Ther. Arch."}],"container-title":["Doklady Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672925700140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S1607672925700140","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672925700140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:17:41Z","timestamp":1773760661000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S1607672925700140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["7685"],"URL":"https:\/\/doi.org\/10.1134\/s1607672925700140","relation":{},"ISSN":["1607-6729","1608-3091"],"issn-type":[{"value":"1607-6729","type":"print"},{"value":"1608-3091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,11]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The ELEFTA study was conducted according to the protocol, International Conference on Harmonisation guidelines and the principles of the Declaration of Helsinki. Before included in the study, all patients provided written informed consent. The trial protocol, protocol amendments, as well as Patient Information Sheet and Informed Consent Form were approved by Independent Ethics Council under the Ministry of Health of the Russian Federation (2022\/03\/01, no. 303) and by the Ethics Committee in each study center before the study initiation.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"ETHICS APPROVAL AND CONSENT TO PARTICIPATE"}},{"value":"The study was sponsored by JSC BIOCAD. The sponsor participated in the development of the study project, study program support, and the decision to submit the article for publication. The conflict of interest did not affect the results of the study. Authors A.V. Zinkina-Orikhan, Yu.N.\u00a0\u00a0Linkova, P.S. Pukhtinskaya, M.A. Morozova, G.A.\u00a0Vinderskaya are employees of JSC BIOCAD.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"CONFLICT OF INTEREST"}}]}}