{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:33:14Z","timestamp":1773772394286,"version":"3.50.1"},"reference-count":28,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1134\/s1607672925700218","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:51:39Z","timestamp":1768236699000},"page":"593-604","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Diversity of Toxigenic Strains of Vibrio cholerae O1 Biovar El Tor Isolated During Three Waves of the 7th Cholera Pandemic"],"prefix":"10.1134","volume":"525","author":[{"given":"N. I.","family":"Smirnova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Rybalchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu. V.","family":"Lozovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya. M.","family":"Krasnov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Yu.","family":"Shchelkanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. V.","family":"Fedorov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. V.","family":"Kutyrev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"137","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"7768_CR1","unstructured":"Baroyan, O.V., Kholera El\u2019-Tor (Cholera Biovar El Tor), Moscow: Meditsina, 1971."},{"key":"7768_CR2","doi-asserted-by":"crossref","unstructured":"Vodop\u2019yanov, S.O., Vodop\u2019yanov, A.S., Oleynikov, I.P., and Titova, S.V., Prevalence of ice elements of different types in V. cholerae, \n               Zdorov\u2019e Naseleniya Sreda Obitaniya, 2018, no. 1, pp. 33\u201335.","DOI":"10.35627\/2219-5238\/2018-298-1-33-35"},{"key":"7768_CR3","doi-asserted-by":"publisher","unstructured":"Kologorov, A.I., Kedrova, O.V., Pakhomov, D.A., Piskunova, N.V., Kovtunov, A.I., Vasenin, A.S., Kabin, V.V., Ilyukhin, A.A., Gracheva, I.V., Razdorskiy, A.S., and Safronov, V.A., Regularities of cholera spread in the Volga basin in 1970\u20131973, Probl. Osobo Opasnykh Infekts., 2010, no. 2104, pp. 22\u201327. https:\/\/doi.org\/10.21055\/0370-1069-2010-2(104)-22-27","DOI":"10.21055\/0370-1069-2010-2(104)-22-27"},{"key":"7768_CR4","doi-asserted-by":"publisher","unstructured":"Monakhova, E.V., Ghosh, A., Mutreja, A., Weill, F.-X., and Ramamurthy, T., Endemic cholera in India and imported cholera in Russia: what is common?, Probl. Osobo Opasnykh Infekts., 2020, no. 3, pp. 17\u201326. https:\/\/doi.org\/10.21055\/0370-1069-2020-3-17-26","DOI":"10.21055\/0370-1069-2020-3-17-26"},{"key":"7768_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.15690\/vramn.v70i2.1320","volume":"70","author":"G.G. Onishchenko","year":"2015","unstructured":"Onishchenko, G.G., Moskvitina, E.A., Kruglikov, V.D., Titova, S.V., Adamenko, O.L., Vodop\u2019yanov, A.S., and Vodop\u2019yanov, S.O., Epidemiological surveillance of cholera in Russia during the period of the seventh pandemic, Vestn. Ross. Akad. Med. Nauk, 2015, vol. 70, no.\u00a02, pp. 249\u2013256. https:\/\/doi.org\/10.15690\/vramn.v70i2.1320","journal-title":"Vestn. Ross. Akad. Med. Nauk"},{"key":"7768_CR6","doi-asserted-by":"publisher","unstructured":"Popova, A.Yu., Noskov, A.K., Ezhlova, E.B., Kruglikov, V.D., Monakhova, E.V., Chemisova, O.S., Lopatin, A.A., Ivanova, S.M., Podoynitsyna, O.A., Vodop\u2019yanov, A.S., Levchenko, D.A., and Savina, I.V., Epidemiological situation on cholera in the Russian Federation in 2023 and forecast for 2024, Probl. Osobo Opasnykh Infekts., 2024, no. 1, pp. 76\u201388. https:\/\/doi.org\/10.21055\/0370-1069-2024-1-76-88","DOI":"10.21055\/0370-1069-2024-1-76-88"},{"key":"7768_CR7","doi-asserted-by":"publisher","unstructured":"Rybal\u2019chenko, D.A., Shchelkanova, E.Yu., Lozovsky,\u00a0Yu.V., Fedorov, A.V., and Smirnova, N.I., Prevalence of different types of integrative conjugative element SXT\/R391 encoding multiple antibiotic resistance among clinical strains of cholera agent, Probl. Osobo Opasnykh Infekts., 2022, no. 1, pp. 137\u2013147. https:\/\/doi.org\/10.21055\/0370-1069-2022-1-137-14769","DOI":"10.21055\/0370-1069-2022-1-137-14769"},{"key":"7768_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3103\/S0891416824700046","volume":"39","author":"D.A. Rybal\u2019chenko","year":"2024","unstructured":"Rybal\u2019chenko, D.A., Lozovsky, Yu.V., Krasnov, Ya.M., Shchelkanova, E.Yu., and Smirnova, N.I., Molecular genetic analysis of Vibrio cholerae O1 El Tor strains identified in 2023 in Russia, Mol. Genet., Microbiol. Virol., 2024, vol. 39, no. 1, pp. 34\u201342. https:\/\/doi.org\/10.3103\/S0891416824700046","journal-title":"Mol. Genet., Microbiol. Virol."},{"key":"7768_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.21055\/0370-1069-2012-4-58-60","volume":"4","author":"V.N. Savel\u2019ev","year":"2012","unstructured":"Savel\u2019ev, V.N., Savel\u2019eva, I.V., Vasil\u2019eva, O.V., Babenyshev, B.V., Kovalev, D.A., Grizhebovsky, G.M., Antonenko, A.D., Kurbanov, Sh.Kh., Butaev, T.M., and Kulichenko, A.N., Evolution of Vibrio cholerae El Tor and detection of their gene variants in the Caucasus, Probl. Osobo Opasnykh Infekts., 2012, vol. 4, no. 114, pp. 58\u201360. https:\/\/doi.org\/10.21055\/0370-1069-2012-4-58-60","journal-title":"Probl. Osobo Opasnykh Infekts."},{"key":"7768_CR10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3103\/S0891416811030062","volume":"26","author":"N.I. Smirnova","year":"2011","unstructured":"Smirnova, N.I., Zadnova, S.P., Shashkova, A.V., and Kutyrev, V.V., Genome variability in the altered variants of Vibrio cholerae biovar El Tor isolated in Russia, Mol. Genet., Microbiol. Virol., 2011, vol. 26, no. 3, pp.\u00a0102\u2013110. https:\/\/doi.org\/10.3103\/S0891416811030062","journal-title":"Mol. Genet., Microbiol. Virol."},{"key":"7768_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3103\/S0891416823010093","volume":"38","author":"N.I. Smirnova","year":"2023","unstructured":"Smirnova, N.I., Rybal\u2019chenko, D.A., Plekhanov, N.A., Lozovsky, Yu.V., Fedorov, A.V., and Kutyrev, V.V., New genetic variants of the Cholera agent and their distribution in endemic countries and Russia, Mol. Genet., Microbiol. Virol., 2023, vol. 38, no. 1, pp. 8\u201315. https:\/\/doi.org\/10.3103\/S0891416823010093","journal-title":"Mol. Genet., Microbiol. Virol."},{"key":"7768_CR12","doi-asserted-by":"publisher","unstructured":"Bhandari, M., Jennison, A.V., Rathnayake, I.U., and Huygens, F., Evolution, distribution and genetics of atypical Vibrio cholerae\u2014a review, Infect., Genet. Evol., 2021, vol. 89, p. 104726. https:\/\/doi.org\/10.1016\/j.meegid.2021.104726","DOI":"10.1016\/j.meegid.2021.104726"},{"key":"7768_CR13","doi-asserted-by":"publisher","first-page":"6291","DOI":"10.1038\/s41467-024-50484-w","volume":"15","author":"Ch. Chaguza","year":"2024","unstructured":"Chaguza, Ch., Chibwe, I., Chaima, D., Musicha, P., Ndeketa, L., Kasambara, W., Mhango, Ch., Mseka,\u00a0U.L., Bitilinyu-Bangoh, J., Mvula, B., Kipandula, W., Bonongwe, P., Munthali, R.J., Ngwira, S., Mwendera, Ch.A., Kalizang\u2019oma, A., Jambo, K.C., Kambalame, D., Kamng\u2019ona, A.W., Steele, A.D., Chauma-Mwale, A., Hungerford, D., Kagoli, M., Nyaga, M.M., Dube, Q., French, N., Msefula, Ch.L., Cunliffe, N.A., and Jere, Kh.C., Genomic insights into the 2022\u20132023 Vibrio cholerae outbreak in Malawi, Nat. Commun., 2024, vol. 15, no. 1, p. 6291. https:\/\/doi.org\/10.1038\/s41467-024-50484-w","journal-title":"Nat. Commun."},{"key":"7768_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.00624-12","volume":"4","author":"J. Dolores","year":"2013","unstructured":"Dolores, J. and Satchell, K.J., Analysis of Vibrio cholerae genome sequences reveals unique rtxA variants in environmental strains and an rtxA-null mutation in recent altered El Tor isolates, mBio, 2013, vol. 4, no. 2, pp.\u00a01\u20139. https:\/\/doi.org\/10.1128\/mBio.00624-12","journal-title":"mBio"},{"key":"7768_CR15","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.3410\/f.1004686.53905","volume":"9","author":"M. Dziejman","year":"2002","unstructured":"Dziejman, M., Balon, E., Boyd, D., Fraser, C.M., Heidelberg, J.F., and Mekalanos, J.J., Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease, Proc. Natl. Acad. Sci. U. S. A., 2002, vol. 9, no. 3, pp. 1556\u20131561. https:\/\/doi.org\/10.3410\/f.1004686.53905","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"7768_CR16","doi-asserted-by":"publisher","unstructured":"Gladkikh, A.S., Feranchuk, S.I., Ponomareva, A.S., Bochalgin, N.O., and Mironova, L.V., Antibiotic resistance in Vibrio cholerae El Tor strains isolated during cholera complications in Siberia and the Far East of Russia, Infect., Genet. Evol., 2020, vol. 78, p. 104096. https:\/\/doi.org\/10.1016\/j.meegid.2019.104096","DOI":"10.1016\/j.meegid.2019.104096"},{"key":"7768_CR17","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1128\/aac.01045-09","volume":"54","author":"H.B. Kim","year":"2010","unstructured":"Kim, H.B., Wang, M., Ahmed, S., Park, Ch.H., Larocque, R.C., Faruque, A.S.G., Salam, M.A., Khan, W.A., Qadri, F., Calderwood, S.B., Jacoby, G.A., and Hoo-per, D.C., Transferable quinolone resistance in Vibrio cholerae, \n               Antimicrob. Agents Chemother., 2010, vol. 54, no. 2, pp. 799\u2013803. https:\/\/doi.org\/10.1128\/aac.01045-09","journal-title":"Antimicrob. Agents Chemother."},{"key":"7768_CR18","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.meegid.2018.02.023","volume":"60","author":"L.V. Mironova","year":"2018","unstructured":"Mironova, L.V., Gladkikh, A.S., Ponomareva, A.S., Feranchuk, S.I., Bochalgin, N.O., Basov, E.A., Khunkheeva, Z.Yu., and Balakhonov, S.V., Comparative genomics of Vibrio cholerae El Tor strains isolated at epidemic complications in Siberia and at the Far East, Infect., Genet. Evol., 2018, vol. 60, pp. 80\u201388. https:\/\/doi.org\/10.1016\/j.meegid.2018.02.023","journal-title":"Infect., Genet. Evol."},{"key":"7768_CR19","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nature10392","volume":"477","author":"A. Mutreja","year":"2011","unstructured":"Mutreja, A., Kim, D.W., Thomson, N.R., Connor, T.R., Lee, J.H., Kariuki, S., Croucher, N.J., Choi, S. Yo., Harris, S.R., Lebens, M., Niyogi, S.K., Kim, E.J., Ramamurthy, T., Chun, J., Wood, J.L.N., Clemens, J.D., Czerkinsky, C., Nair, G.B., Holmgren, J., Parkhill, J., and Dougan, G., Evidence for several waves of global transmission in the seventh cholera pandemic, Nature, 2011, vol. 477, no. 7365, pp. 462\u2013465. https:\/\/doi.org\/10.1038\/nature10392","journal-title":"Nature"},{"key":"7768_CR20","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1128\/jcm.40.9.3296-3299.2002","volume":"40","author":"G.B. Nair","year":"2002","unstructured":"Nair, G.B., Faruque, Sh.M., Bhuiyan, N.A., Kamruzzaman, M., Siddique, A.K., and Sack, D.A., New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in Bangladesh, J. Clin. Microbiol., 2002, vol. 40, no. 9, pp. 3296\u20133299. https:\/\/doi.org\/10.1128\/jcm.40.9.3296-3299.2002","journal-title":"J. Clin. Microbiol."},{"key":"7768_CR21","doi-asserted-by":"publisher","first-page":"a7","DOI":"10.1016\/j.vaccine.2019.06.034","volume":"38","author":"A. Pant","year":"2020","unstructured":"Pant, A., Das, B., and Bhadra, R.K., CTX phage of Vibrio cholerae: genomics and applications, Vaccine, 2020, vol. 38, no. 38, pp. a7\u2013a12. https:\/\/doi.org\/10.1016\/j.vaccine.2019.06.034","journal-title":"Vaccine"},{"key":"7768_CR22","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.3201\/eid1711.110794","volume":"17","author":"A. Reimer","year":"2011","unstructured":"Reimer, A., Domselaar, G., Stroika, S., Walker, M., Kent, H., Tarr, Ch., Talkington, D., Rowe, L., Olsen-Rasmussen, M., Frace, M., Sammons, S., Dahourou, G., Boncy, J., Smith, A., Mabon, P., Petkau, A., Graham, M., Gilmour, M., and Gerner-Smidt, P., Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa, Emerging Infect. Dis., 2011, vol. 17, no. 11, pp. 2113\u20132121. https:\/\/doi.org\/10.3201\/eid1711.110794","journal-title":"Emerging Infect. Dis."},{"key":"7768_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.tim.2009.10.003","volume":"18","author":"A. Safa","year":"2010","unstructured":"Safa, A., Nair, G.B., and Kong, R.Y.C., Evolution of new variants of Vibrio cholerae O1, Trends Microbiol., 2010, vol. 18, no. 1, pp. 46\u201354. https:\/\/doi.org\/10.1016\/j.tim.2009.10.003","journal-title":"Trends Microbiol."},{"key":"7768_CR24","doi-asserted-by":"publisher","first-page":"e00080","DOI":"10.1128\/iai.00080-20","volume":"88","author":"P. Samanta","year":"2020","unstructured":"Samanta, P., Mandal, R.Sh., Saha, R.N., Shaw, S., Ghosh, P., Dutta, Sh., Ghosh, A., Imamura, D., Morita, M., Ohnishi, M., Ramamurthy, T., and Mu-khopadhyay, A.K., A point mutation in carR is involved in the emergence of polymyxin B-sensitive Vibrio cholerae O1 El Tor biotype by influencing gene transcription, Infect. Immun., 2020, vol. 88, no. 5, pp. e00080\u201320. https:\/\/doi.org\/10.1128\/iai.00080-20","journal-title":"Infect. Immun."},{"key":"7768_CR25","doi-asserted-by":"publisher","first-page":"e01356","DOI":"10.1128\/mbio.01356-14","volume":"5","author":"M. Spagnoletti","year":"2014","unstructured":"Spagnoletti, M., Ceccarelli, D., Rieux, A., Fondi, M., Taviani, E., Fani, R., Colombo, M.M., Colwell, R.R., and Balloux, F., Acquisition and evolution of SXT-R391 integrative conjugative elements in the seventh-pandemic Vibrio cholerae lineage, mBio, 2014, vol. 5, no. 4, pp.\u00a0e01356\u201314. https:\/\/doi.org\/10.1128\/mbio.01356-14","journal-title":"mBio"},{"key":"7768_CR26","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.3201\/eid1711.110805","volume":"17","author":"D. Talkington","year":"2011","unstructured":"Talkington, D., Bopp, Ch., Tarr, Ch., Parsons, M., Dahourou, G., Freeman, M., Joyce, K., Turnsek, M., Garrett, N., Humphrys, M., Gomez, G., Stroika, S., Boncy, J., Ochieng, B., Oundo, J., Klena, J., Smith, A., Keddy, K., and Gerner-Smidt, P., Characterization of toxigenic Vibrio cholerae from Haiti, 2010\u20132011, Emerging Infect. Dis., 2011, vol. 17, no. 11, pp. 2122\u20132129. https:\/\/doi.org\/10.3201\/eid1711.110805","journal-title":"Emerging Infect. Dis."},{"key":"7768_CR27","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1574-6968.2010.02008.x","volume":"308","author":"E. Taviani","year":"2010","unstructured":"Taviani, E., Grim, Ch.J., Choi, J., Chun, J., Haley, B., Hasan, N.A., Huq, A., and Colwell, R.R., Discovery of novel Vibrio cholerae VSP-II genomic islands using comparative genomic analysis, FEMS Microbiol. Lett., 2010, vol. 308, pp. 130\u2013137. https:\/\/doi.org\/10.1111\/j.1574-6968.2010.02008.x","journal-title":"FEMS Microbiol. Lett."},{"key":"7768_CR28","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1126\/science.aad5901","volume":"358","author":"F.X. Weill","year":"2017","unstructured":"Weill, F.X., Domman, D., Njamkepo, E., Tarr, C., Rauzier, J., Fawal, N., Keddy, K.H., Salje, H., Moore, S., Mukhopadhyay, A.K., Bercion, R., Luquero, F.J., Ngandjio, A., Dosso, M., Monakhova, E., Garin, B., Bouchier, C., Pazzani, C., Mutreja, A., Grunow, R., Sidikou, F., Bonte, L., Breurec, S., Damian, M., Njanpop-Lafourcade, B.M., Sapriel, G., Page, A.L., Hamze, M., Henkens, M., Chowdhury, G., Mengel, M., Koeck, J.L., Fournier, J.M., Dougan, G., Gri-mont,\u00a0P.A.D., Parkhill, J., Holt, K.E., Piarroux, R., Ramamurthy, T., Quilici, M.L., and Thomson, N.R., Genomic history of the seventh pandemic of cholera in Africa, Science, 2017, vol. 358, no. 6364, pp. 785\u2013789.","journal-title":"Science"}],"container-title":["Doklady Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672925700218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S1607672925700218","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672925700218.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:17:40Z","timestamp":1773760660000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S1607672925700218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["7768"],"URL":"https:\/\/doi.org\/10.1134\/s1607672925700218","relation":{},"ISSN":["1607-6729","1608-3091"],"issn-type":[{"value":"1607-6729","type":"print"},{"value":"1608-3091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"20 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This work does not contain any studies involving human and animal subjects.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"ETHICS APPROVAL AND CONSENT TO PARTICIPATE"}},{"value":"The authors of this work declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"CONFLICT OF INTEREST"}}]}}