{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:10:39Z","timestamp":1767165039373,"version":"build-2238731810"},"reference-count":31,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Perinatal asphyxia is associated with cardiac dysfunction secondary to myocardial ischaemia. Cardiac troponin I (cTnI) is a marker of myocardial necrosis. Raised concentrations in the blood are related to perinatal asphyxia and increased morbidity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To assess porcine myocardial damage from enzyme release during hypoxaemia induced global ischaemia, and subsequent resuscitation with ambient air or 100% O\n                    <jats:sub>2<\/jats:sub>\n                    . To investigate whether CO\n                    <jats:sub>2<\/jats:sub>\n                    level during resuscitation influences myocardial damage.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design:<\/jats:bold>\n                    Newborn piglets (12\u201336 hours) were exposed to hypoxaemia by ventilation with 8% O\n                    <jats:sub>2<\/jats:sub>\n                    in nitrogen. When mean arterial blood pressure had fallen to 15 mm Hg, or base excess to &lt; \u221220 mmol\/l, the animals were randomly resuscitated by ventilation with either 21% O\n                    <jats:sub>2<\/jats:sub>\n                    (group A, n\u200a=\u200a29) or 100% O\n                    <jats:sub>2<\/jats:sub>\n                    (group B, n\u200a=\u200a29) for 30 minutes. Afterwards they were observed in ambient air for another 150 minutes. During resuscitation, the two groups were further divided into three subgroups with different CO\n                    <jats:sub>2<\/jats:sub>\n                    levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Analysis:<\/jats:bold>\n                    Blood samples were analysed for cTnI, myoglobin, and creatine kinase-myocardial band (CK-MB) at baseline and at the end of the study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    cTnI increased more than 10-fold (p &lt; 0.001) in all the groups. Myoglobin and CK-MB doubled in concentration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The considerable increase in cTnI indicates seriously affected myocardium. Reoxygenation with 100% oxygen offered no biochemical benefit over ambient air. CK-MB and myoglobin were not reliable markers of myocardial damage. Normoventilation tended to produce better myocardial outcome than hyperventilation or hypoventilation.\n                  <\/jats:p>","DOI":"10.1136\/adc.2002.020594","type":"journal-article","created":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T15:10:45Z","timestamp":1082387445000},"page":"F156-F160","source":"Crossref","is-referenced-by-count":30,"title":["Resuscitation with 100% O\n                    <sub>2<\/sub>\n                    does not protect the myocardium in hypoxic newborn piglets"],"prefix":"10.1136","volume":"89","author":[{"given":"W B","family":"B\u00f8rke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B H","family":"Munkeby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"M\u00f8rkrid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Thaulow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O D","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"2025090512014649000_89.2.F156.1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0095-5108(18)30395-6","volume":"20","year":"1993","journal-title":"Clin Perinatol"},{"key":"2025090512014649000_89.2.F156.2","unstructured":"World Health Organization. World Health Report 2002. Geneva: WHO, 2003."},{"key":"2025090512014649000_89.2.F156.3","unstructured":"World Health Organization. Child health and development: health of the newborn. 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