{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:50:11Z","timestamp":1761918611228,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>\n                  <jats:bold>Aims:<\/jats:bold> (<jats:italic>a<\/jats:italic>) To measure infant angiotensin converting enzyme (ACE) activity in healthy term infants at birth and during the first three months of life. (<jats:italic>b<\/jats:italic>) To determine the relation between serum ACE activity and infant feeding practice during this period. (<jats:italic>c<\/jats:italic>) To investigate the relation between serum ACE activity and birth weight and other potential contributing factors including acid-base status at birth, gestation, and maternal ACE genotype.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Prospective study of term infants, with clinical and feeding data collected from parents and medical records, and serum ACE measured in the infant at birth and 1 and 3 months of age, and in the mother at the time of birth and one to three months after birth.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> At birth and 1 and 3 months of age, infant serum ACE activity was twice that of maternal ACE activity. Infant ACE activity at birth and 1 and 3 months did not significantly differ between breast and formula fed infants. There was a highly significant negative correlation between infant ACE activity at 3 months and birth weight (<jats:italic>r<\/jats:italic>\u00a0\u200a=\u200a\u00a0\u22120.52; p\u00a0&lt;\u00a00.001). This persisted after the conversion of birth weights to z scores (<jats:italic>r<\/jats:italic>\u00a0\u200a=\u200a\u00a0\u22120.34; p\u00a0\u200a=\u200a\u00a00.03). ACE activity at 3 months was also related to placental weight (<jats:italic>r<\/jats:italic>\u00a0\u200a=\u200a\u00a0\u22120.30; p\u00a0\u200a=\u200a\u00a00.02) and maternal age (<jats:italic>r<\/jats:italic>\u00a0\u200a=\u200a\u00a0\u22120.30; p\u00a0\u200a=\u200a\u00a00.05). The strong correlation between serum ACE activity and birth weight z score persisted after adjustment for maternal age and placental weight (<jats:italic>r<\/jats:italic>\u00a0\u200a=\u200a\u00a0\u22120.34; p\u00a0\u200a=\u200a\u00a00.03).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> As ACE is increasingly identified as a risk factor for cardiovascular disease, serum ACE activity in infancy may contribute to the link between low birth weight and later cardiovascular events.<\/jats:p>","DOI":"10.1136\/adc.2003.027896","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T16:12:08Z","timestamp":1093018328000},"page":"F442-F444","source":"Crossref","is-referenced-by-count":19,"title":["Angiotensin converting enzyme activity in infancy is related to birth weight"],"prefix":"10.1136","volume":"89","author":[{"given":"J S","family":"Forsyth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C G","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A D","family":"Struthers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2004,8,20]]},"reference":[{"key":"2025090510074474000_89.5.F442.1","doi-asserted-by":"crossref","first-page":"1344S","DOI":"10.1093\/ajcn\/71.5.1344s","volume":"71","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"2025090510074474000_89.5.F442.2","doi-asserted-by":"crossref","unstructured":"Lucas A . 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