{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:11:57Z","timestamp":1785499917303,"version":"3.56.0"},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2005,7]]},"abstract":"\n Objectives:<\/jats:bold> To study the epidemiology of early onset neonatal bacterial meningitis (EONBM) in Australasia.<\/jats:p>\n \n Design:<\/jats:bold> Prospective surveillance study, 1992\u20132002, in 20 neonatal units in Australia and New Zealand. EONBM was defined as meningitis occurring within 48 hours of delivery.<\/jats:p>\n \n Results:<\/jats:bold> There were 852 babies with early onset sepsis, of whom 78 (9.2%) had EONBM. The incidence of early onset group B streptococcal meningitis fell significantly from a peak of 0.24\/1000 live births in 1993 to 0.03\/1000 in 2002 (p trend \u200a=\u200a 0.002). There was no significant change over time in the incidence of Escherichia coli<\/jats:italic> meningitis. The rate of EONBM in very low birthweight babies was 1.09\/1000 compared with the rate in all infants of 0.11\/1000. The overall rate of EONBM was 0.41\/1000 in 1992 and 0.06 in 2001, but this trend was not significant (p trend \u200a=\u200a 0.07). Case-fatality rates for EONBM did not change significantly with time. Birth weight <1500 g (odds ratio (OR) 7.2 (95% confidence interval (CI) 4.8 to 10.9)) and Gram negative bacillary meningitis (OR 3.3 (95% CI 2.2 to 4.9)) were significant risk factors for mortality. Sixty two percent of the 129 babies who died from early onset sepsis or suspected sepsis did not have a lumbar puncture performed.<\/jats:p>\n \n Conclusion:<\/jats:bold> The incidence of early onset group B streptococcal meningitis has fallen, probably because of maternal intrapartum antibiotic prophylaxis, without a corresponding change in E coli<\/jats:italic> meningitis. Gram negative bacillary meningitis still carries a worse prognosis than meningitis with a Gram positive organism.<\/jats:p>","DOI":"10.1136\/adc.2004.066134","type":"journal-article","created":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T20:19:08Z","timestamp":1115410748000},"page":"F324-FF327","source":"Crossref","is-referenced-by-count":89,"title":["Early onset neonatal meningitis in Australia and New Zealand, 1992\u20132002"],"prefix":"10.1136","volume":"90","author":[{"given":"M","family":"May","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Donath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"2025090501332112000_90.4.F324.1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.5694\/j.1326-5377.1992.tb139741.x","volume":"156","year":"1992","journal-title":"Med J Aust"},{"key":"2025090501332112000_90.4.F324.2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.5694\/j.1326-5377.1995.tb126024.x","volume":"162","year":"1995","journal-title":"Med J Aust"},{"key":"2025090501332112000_90.4.F324.3","doi-asserted-by":"crossref","first-page":"F75","DOI":"10.1136\/fn.71.2.F75","volume":"71","year":"1994","journal-title":"Arch Dis Child"},{"key":"2025090501332112000_90.4.F324.4","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199906000-00009"},{"key":"2025090501332112000_90.4.F324.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.1094"},{"key":"2025090501332112000_90.4.F324.6","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/01.inf.0000128782.20060.79","volume":"23","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"2025090501332112000_90.4.F324.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.4.690"},{"key":"2025090501332112000_90.4.F324.8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.1_Spec_No.14"},{"key":"2025090501332112000_90.4.F324.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012657"},{"key":"2025090501332112000_90.4.F324.10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00006454-200102000-00003","volume":"20","year":"2001","journal-title":"Pediatr Infect Dis J"},{"key":"2025090501332112000_90.4.F324.11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.e10"},{"key":"2025090501332112000_90.4.F324.12","doi-asserted-by":"publisher","DOI":"10.1177\/000992280104000901"},{"key":"2025090501332112000_90.4.F324.13","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1992.02160170047014"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2004.066134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T08:34:07Z","timestamp":1757061247000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2004.066134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,5]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,6,21]]},"published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1136\/adc.2004.066134"],"URL":"https:\/\/doi.org\/10.1136\/adc.2004.066134","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,5]]}}}