{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:34:19Z","timestamp":1773819259515,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>\n                  <jats:bold>Aim:<\/jats:bold> To evaluate the safety of transporting newborn infants with suspected duct dependent congenital heart disease (CHD) treated with prostaglandin E1 (PGE1) without routine mechanical ventilation.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> A retrospective population-based audit of newborn infants with suspected CHD transported on PGE1 by the New South Wales newborn and paediatric Transport Service from 1995 through 2005.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Mechanical ventilation was not used prior to treatment with PGE1 in 94 (31%) of the 300 infants. The indications for mechanical ventilation in the remaining 206 infants (69%) included elective mechanical ventilation because of the intention to use PGE1 (n \u200a=\u200a 125) and severe hypoxaemia, acidosis or cardiorespiratory failure prior to commencing PGE1 (n \u200a=\u200a 81). 16 (17%) of the 94 infants who were not ventilated initially required mechanical ventilation before transport because of apnoea, which developed within one hour of commencing PGE1. 2 (2.6%) of the 78 infants transported without mechanical ventilation developed apnoea in transit and both were receiving \u2a7e15 ng\/kg\/min of PGE1. Apnoea was more likely to occur in non-ventilated infants when the PGE1 infusion rate was \u2a7e15 ng\/kg\/min compared with &lt;15 ng\/kg\/min (14\/33 vs 4\/61, \u03c7<jats:sup>2<\/jats:sup> \u200a=\u200a 15.55, p&lt;.001).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Newborn infants with suspected duct dependent CHD treated with low dose PGE1 (&lt;15 ng\/kg\/min) may not require mechanical ventilation for safe transport.<\/jats:p>","DOI":"10.1136\/adc.2006.096305","type":"journal-article","created":{"date-parts":[[2006,8,11]],"date-time":"2006-08-11T20:13:58Z","timestamp":1155327238000},"page":"F117-F119","source":"Crossref","is-referenced-by-count":54,"title":["Transporting newborn infants with suspected duct dependent congenital heart disease on low-dose prostaglandin E1 without routine mechanical ventilation: \n            Table 1"],"prefix":"10.1136","volume":"92","author":[{"given":"Kathryn A","family":"Browning Carmo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil W","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer P","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Badawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2006,8,11]]},"reference":[{"key":"2025090512223367000_92.2.F117.1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/fn.84.3.F141","volume":"84","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090512223367000_92.2.F117.2","unstructured":"Mackway-Jones K, Molyneux E, Phillips B, et al. Advanced paediatric life support, 4th edn. London: BMJ Publishing Group 2004:110."},{"key":"2025090512223367000_92.2.F117.3","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/adc.2004.064949","volume":"90","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090512223367000_92.2.F117.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF02276712"},{"key":"2025090512223367000_92.2.F117.5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s002460010254","volume":"22","year":"2001","journal-title":"Pediatr Cardiol"},{"key":"2025090512223367000_92.2.F117.6","first-page":"377","volume":"15","year":"1994","journal-title":"Eur Heart J"},{"key":"2025090512223367000_92.2.F117.7","unstructured":"Greenough A, Miller AD. Management of neonatal respiratory failure. In: Rennie JM, ed. Roberton\u00e2\u0080\u0099s textbook of neonatology. Edinburgh: Churchill Livingstone, 2005:519\u00e2\u0080\u009335."},{"key":"2025090512223367000_92.2.F117.8","unstructured":"NETS. NSW newborn & p\u00c3\u00a6diatric Emergency Transport Service. Sydney, http:\/\/www.nets.org.au 2005."},{"key":"2025090512223367000_92.2.F117.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.e27"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2006.096305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:22:39Z","timestamp":1757100159000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2006.096305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,11]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,3,2]]},"published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1136\/adc.2006.096305"],"URL":"https:\/\/doi.org\/10.1136\/adc.2006.096305","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,11]]}}}