{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:24:10Z","timestamp":1788305050291,"version":"build-2803163510"},"reference-count":26,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>\n                  <jats:bold>Background:<\/jats:bold> A patent ductus arteriosus (PDA) is common among preterms, and prophylactic medical treatment has been advocated as the first-line approach. Conservative treatment may result in similar outcome, but without exposure to the harmful side effects of medication. A retrospective analysis revealed a ductal closure rate of 94% after conservative treatment with adjustment of ventilation (lowering the inspiratory time and increasing positive end expiratory pressure) and fluid restriction.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To study prospectively over one year the rate of PDA closure, and morbidity and mortality following conservative treatment.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Method:<\/jats:bold> Prospective study (1 January 2005 \u2013 31 December 2005) including 30 newborns \u2a7d30 weeks\u2019 gestation, all of whom were being ventilated and required surfactant. Echocardiography was performed 48\u201372 h after birth. Clinically important PDA was conservatively treated as described above. The percentage of children with PDA, ductal ligation and major complications was determined.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Ten neonates (33%) developed a clinical important PDA. Following conservative treatment the duct closed in all neonates (100%), and none required ductal ligation or medical treatment. The rates of major complications were no higher than those reported by the Vermont Oxford Network and in the literature.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> The managed care plan resulted in an overall ductal closure rate of 100%. These results suggest that conservative treatment of PDA is a worthy alternative to prophylactic medical treatment.<\/jats:p>","DOI":"10.1136\/adc.2006.104596","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T23:37:29Z","timestamp":1168385849000},"page":"F244-F247","source":"Crossref","is-referenced-by-count":88,"title":["Conservative treatment for patent ductus arteriosus in the preterm"],"prefix":"10.1136","volume":"92","author":[{"given":"Sophie","family":"Vanhaesebrouck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Zonnenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Vandervoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Bruneel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Rose","family":"Van Hoestenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Theyskens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,1,9]]},"reference":[{"key":"2025090503375113000_92.4.F244.1","doi-asserted-by":"crossref","first-page":"F179","DOI":"10.1136\/fn.76.3.F179","volume":"76","year":"1997","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090503375113000_92.4.F244.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(03)00121-0"},{"key":"2025090503375113000_92.4.F244.3","first-page":"CD003951","volume":"3","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2025090503375113000_92.4.F244.4","first-page":"27","volume":"22","year":"2003","journal-title":"Neonatal Netw"},{"key":"2025090503375113000_92.4.F244.5","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2000.0036"},{"key":"2025090503375113000_92.4.F244.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17476-X"},{"key":"2025090503375113000_92.4.F244.7","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(85)90135-5"},{"key":"2025090503375113000_92.4.F244.8","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(91)90028-2"},{"key":"2025090503375113000_92.4.F244.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1528"},{"key":"2025090503375113000_92.4.F244.10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02424985"},{"key":"2025090503375113000_92.4.F244.11","first-page":"CD004213","volume":"2","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2025090503375113000_92.4.F244.12","first-page":"CD003481","volume":"2","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2025090503375113000_92.4.F244.13","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2001.047"},{"key":"2025090503375113000_92.4.F244.14","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.065946"},{"key":"2025090503375113000_92.4.F244.15","first-page":"CD000174","volume":"3","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"2025090503375113000_92.4.F244.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17477-1"},{"key":"2025090503375113000_92.4.F244.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17492-8"},{"key":"2025090503375113000_92.4.F244.18","first-page":"CD003745","volume":"2","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2025090503375113000_92.4.F244.19","unstructured":"Vermont Oxford Network. http:\/\/www.vrtoxford.org."},{"key":"2025090503375113000_92.4.F244.20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530310045031"},{"key":"2025090503375113000_92.4.F244.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70060-X"},{"key":"2025090503375113000_92.4.F244.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70093-4"},{"key":"2025090503375113000_92.4.F244.23","doi-asserted-by":"publisher","DOI":"10.1080\/080352500300002598"},{"key":"2025090503375113000_92.4.F244.24","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051288"},{"key":"2025090503375113000_92.4.F244.25","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200001000-00009"},{"key":"2025090503375113000_92.4.F244.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431001"}],"container-title":["Archives of Disease in Childhood - 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