{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:18:52Z","timestamp":1779887932630,"version":"3.53.1"},"reference-count":20,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To determine the incidence of severe hyperbilirubinaemia in the newborn, and to identify associated clinical and demographic variables, and short-term outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>Prospective, population-based study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting:<\/jats:title>\n                  <jats:p>UK and Republic of Ireland, between 1 May 2003 and 31 May 2005.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants:<\/jats:title>\n                  <jats:p>Infants in the first month of life with severe hyperbilirubinaemia (maximum unconjugated serum bilirubin \u2a7e510 \u03bcmol\/l).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>108 infants met the case definition, 106 from the UK and 2 from the Republic of Ireland. The UK incidence of severe hyperbilirubinaemia was 7.1\/100\u2009000 live births (95% CI 5.8 to 8.6). Only 20 cases presented in hospital; 88 were admitted with severe jaundice. 64 (60.4%) cases were male, and 56 (51.8%) were of ethnic minority origin. 87 (80.5%) cases were exclusively breast fed. Co-morbidity included haemolysis, dehydration, infection and bruising. 14 infants showed evidence of bilirubin encephalopathy, of whom 3 died. The UK incidence of bilirubin encephalopathy was 0.9\/100\u2009000 live births (95% CI 0.46 to 1.5).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>This is the first large, prospective, population-based study of the incidence of severe hyperbilirubinaemia in the newborn. The clinical and demographic associations, and short-term outcomes identified, are the same as those reported recently in North America and Europe.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2006.105361","type":"journal-article","created":{"date-parts":[[2006,10,30]],"date-time":"2006-10-30T20:25:10Z","timestamp":1162239910000},"page":"F342-F346","source":"Crossref","is-referenced-by-count":186,"title":["Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland"],"prefix":"10.1136","volume":"92","author":[{"given":"Donal","family":"Manning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jane Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2006,10,30]]},"reference":[{"key":"2025090514402750000_92.5.F342.1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1542\/peds.96.4.730","article-title":"Kernicterus in otherwise healthy, breast-fed term newborns.","volume":"96","author":"Maisels","year":"1995","journal-title":"Pediatrics"},{"key":"2025090514402750000_92.5.F342.2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1542\/peds.96.4.727","article-title":"Hospital readmission due to neonatal hyperbilirubinaemia.","volume":"96","author":"Seidman","year":"1995","journal-title":"Pediatrics"},{"key":"2025090514402750000_92.5.F342.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70170-2"},{"key":"2025090514402750000_92.5.F342.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.6.1198"},{"key":"2025090514402750000_92.5.F342.5","doi-asserted-by":"publisher","DOI":"10.1080\/080352500750027592"},{"key":"2025090514402750000_92.5.F342.6","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.123098"},{"key":"2025090514402750000_92.5.F342.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.4.775"},{"key":"2025090514402750000_92.5.F342.8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211152"},{"key":"2025090514402750000_92.5.F342.9","doi-asserted-by":"publisher","DOI":"10.1080\/08035250410022170"},{"key":"2025090514402750000_92.5.F342.10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0095-5108(18)30573-6","article-title":"Clinical features of bilirubin encephalopathy.","volume":"17","author":"Connolly","year":"1990","journal-title":"Clin Perinatol"},{"key":"2025090514402750000_92.5.F342.11","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101600615"},{"key":"2025090514402750000_92.5.F342.12","doi-asserted-by":"crossref","first-page":"F374","DOI":"10.1136\/adc.2003.037242","article-title":"Increasing incidence of moderate neonatal hyperbilirubinaemia in Wirral.","volume":"89","author":"Walston","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090514402750000_92.5.F342.13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.6.995"},{"key":"2025090514402750000_92.5.F342.14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.1303"},{"key":"2025090514402750000_92.5.F342.15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1542\/peds.78.5.837","article-title":"Normal serum bilirubin levels in the newborn and the effect of breast-feeding.","volume":"78","author":"Maisels","year":"1986","journal-title":"Pediatrics"},{"key":"2025090514402750000_92.5.F342.16","doi-asserted-by":"publisher","DOI":"10.1080\/08035250410025159"},{"key":"2025090514402750000_92.5.F342.17","unstructured":"British Paediatric Surveillance Unit. 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