{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:27:51Z","timestamp":1791167271014,"version":"4.1.0"},"reference-count":31,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Appropriate ventilation together with improvement of clinical care of premature babies can contribute to reducing lung inflammation, known to represent the \u201cprimum movens\u201d of bronchopulmonary dysplasia (BPD). High-frequency oscillatory ventilation (HFOV) and volume-guarantee (VG) ventilation are effective in the treatment of neonatal respiratory distress syndrome (RDS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To assess the potential of HFOV and VG to prevent BPD in the acute phase of RDS, by a randomised clinical study evaluating lung inflammation in premature infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study design:<\/jats:title>\n                  <jats:p>Forty infants (gestational age 25\u201332 weeks) with RDS were assigned to assist-control ventilation plus VG (Vt\u200a=\u200a5 ml\/kg) or HFOV (both with a Dr\u00e4ger Babylog 8000 plus ventilator). Levels of interleukin (IL) 6, IL8 and tumour necrosis factor were determined in tracheal aspirate on days 1, 3 and 7 of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>In the HFOV group IL6 levels were significantly higher on day 3 (0.5 (0.2) vs assisted-control ventilation plus VG group 0.1 (0.2) ng\/ml) and oxygen dependency was significantly longer (36 (23) vs assisted-control ventilation plus VG group 19 (11) days).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>VG ventilation is an effective lung-protective strategy to be used in acute RDS, inducing a lower expression of early inflammation markers than HFOV. Whether the use of this initial ventilatory strategy contributes to the prevention of BPD requires further studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2006.112102","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T23:57:31Z","timestamp":1175644651000},"page":"F252-F256","source":"Crossref","is-referenced-by-count":40,"title":["Volume guarantee versus high-frequency ventilation: lung inflammation in preterm infants"],"prefix":"10.1136","volume":"93","author":[{"given":"G","family":"Lista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Castoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Battaglioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Cavigioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Bosoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,4,3]]},"reference":[{"key":"2025090512452322000_93.4.F252.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"2025090512452322000_93.4.F252.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2006.05.003"},{"key":"2025090512452322000_93.4.F252.3","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000036626.67304.65"},{"key":"2025090512452322000_93.4.F252.4","doi-asserted-by":"publisher","DOI":"10.1159\/000063608"},{"key":"2025090512452322000_93.4.F252.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)00190-2"},{"key":"2025090512452322000_93.4.F252.6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.112"},{"key":"2025090512452322000_93.4.F252.7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1152\/jappl.1980.48.4.710","article-title":"Ventilation by high-frequency oscillation.","volume":"48","author":"Bohn DJ Miyasaka","year":"1980","journal-title":"J Appl Physiol"},{"key":"2025090512452322000_93.4.F252.8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1203\/00006450-199010000-00013","article-title":"Proximal, tracheal, and alveolar pressures during high-frequency oscillatory ventilation in a normal rabbit model.","volume":"28","author":"Gerstmann","year":"1990","journal-title":"Pediatr Res"},{"key":"2025090512452322000_93.4.F252.9","doi-asserted-by":"crossref","unstructured":"Henderson-Smart DJ Bhuta T Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. 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