{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:27:11Z","timestamp":1765826831108,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>The estimated incidence of true early-onset group B streptococcal (GBS) neonatal infection is based on positive GBS blood or cerebrospinal fluid (CSF) culture results, but the real burden of disease is underestimated owing to the high incidence of culture-negative sepsis possibly because of antibiotic administration to the mother.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To examine the rate of probable early-onset GBS neonatal sepsis and to assess its impact on total GBS neonatal disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>A multicentre longitudinal prospective surveillance of 107\u2009021 deliveries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The rates of culture-proven and probable early-onset GBS sepsis were 0.39 and 0.47 per 1000 live births, respectively. Of great concern was the finding of three deaths related to the infection in the group with probable early-onset GBS sepsis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The use of chemoprophylaxis in GBS-colonised pregnant women, especially when it is incomplete, may not be sufficient to prevent clinical neonatal infection, but may inhibit the growth of GBS in blood and CSF cultures. In assessing the effectiveness of GBS prophylaxis, it is advisable to consider the incidence of culture-positive and probable culture-negative GBS neonatal infection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2007.119958","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T20:18:57Z","timestamp":1187381937000},"page":"F85-F89","source":"Crossref","is-referenced-by-count":28,"title":["Probable early-onset group B streptococcal neonatal sepsis: a serious clinical condition related to intrauterine infection"],"prefix":"10.1136","volume":"93","author":[{"given":"X","family":"Carbonell-Estrany","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Figueras-Aloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Salcedo-Abizanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"de la Rosa-Fraile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Castrillo Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2007,8,17]]},"reference":[{"key":"2025090501463090000_93.2.F85.1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2000.039"},{"key":"2025090501463090000_93.2.F85.2","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC.","volume":"51","author":"Centers for Disease Control and Prevention","year":"2002","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025090501463090000_93.2.F85.3","doi-asserted-by":"publisher","DOI":"10.1080\/08035250410025302"},{"key":"2025090501463090000_93.2.F85.4","first-page":"1205","article-title":"Early-onset and late-onset neonatal group B streptococcal disease\u2014United States, 1996\u20132004.","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025090501463090000_93.2.F85.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13553-2"},{"key":"2025090501463090000_93.2.F85.6","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000239267.42561.06"},{"key":"2025090501463090000_93.2.F85.7","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1128\/JCM.37.8.2674-2677.1999","article-title":"Use of Granada medium to detect group B streptococcal colonization in pregnant women.","volume":"37","author":"Rosa-Fraile","year":"1999","journal-title":"J Clin Microbiol"},{"key":"2025090501463090000_93.2.F85.8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1469-0691.2001.00156.x","article-title":"Modified Granada agar medium for the detection of group B streptococcus carriage in pregnant women.","volume":"7","author":"Claeys","year":"2001","journal-title":"Clin Microb Infect"},{"key":"2025090501463090000_93.2.F85.9","first-page":"705","article-title":"Evaluation du milieu Granada appliqu\u00e9 au despistage de Streptococcusa agalactiae au huit\u00e8me mois de grossese.","volume":"61","author":"Rolland","year":"2003","journal-title":"Ann Biol Clin (Paris)"},{"key":"2025090501463090000_93.2.F85.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606263142603"},{"key":"2025090501463090000_93.2.F85.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(85)91955-3"},{"key":"2025090501463090000_93.2.F85.12","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.5.810"},{"key":"2025090501463090000_93.2.F85.13","doi-asserted-by":"crossref","unstructured":"Edwards MS Nizet V Baker CJ . Group B streptococcal infection. In: Remington JS Klein JOR , eds. Infectious diseases of the fetus and newborn infant. 6th ed. Philadelphia: Elsevier Saunders, 2006:403\u201364.","DOI":"10.1016\/B0-72-160537-0\/50015-3"},{"key":"2025090501463090000_93.2.F85.14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1114"},{"key":"2025090501463090000_93.2.F85.15","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60590-9"},{"key":"2025090501463090000_93.2.F85.16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1594"},{"key":"2025090501463090000_93.2.F85.17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1542\/peds.2004-2275","article-title":"Early-onset group B streptococcal disease in the era of maternal screening.","volume":"115","author":"Puopolo","year":"2005","journal-title":"Pediatrics"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2007.119958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T08:46:42Z","timestamp":1757062002000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2007.119958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,17]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,22]]},"published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1136\/adc.2007.119958"],"URL":"https:\/\/doi.org\/10.1136\/adc.2007.119958","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"type":"print","value":"1359-2998"},{"type":"electronic","value":"1468-2052"}],"subject":[],"published":{"date-parts":[[2007,8,17]]}}}