{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:00:28Z","timestamp":1792670428343,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2008,7]]},"abstract":"\n Background:<\/jats:title>\n Surgical closure of a patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants has been associated with impaired neurodevelopmental outcome. Surgical PDA closure may result in abrupt changes of cerebral haemodynamics.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To examine the cerebral blood volume changes occurring after surgical closure of PDA.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Continuous cerebral near-infrared spectroscopy (NIRS) recording throughout PDA surgery.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Tertiary neonatal intensive care unit, with PDA surgery performed on the ward.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n Ten VLBW infants, median birth weight 748 g (range 590\u20131070), gestational age 24 (23\u201327) weeks, chronological age 14 (12\u201322) days.<\/jats:p>\n <\/jats:sec>\n \n Intervention:<\/jats:title>\n Surgical closure of PDA.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures:<\/jats:title>\n Changes in cerebral oxygenated haemoglobin, cerebral deoxygenated haemoglobin, and tissue oxygenation index (measured), changes in cerebral blood volume (CBV) and cerebral haemoglobin difference (calculated) as measured by NIRS.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n During the first 2 minutes after closure of the PDA, CBV increased significantly (mean (SD) 0.14 (0.12) ml\/100 g tissue; p\u200a=\u200a0.01) and returned to baseline within 2\u20135 minutes. Cerebral oxygenation did not change.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n There is a short-lasting increase in CBV immediately after surgical closure of PDA, but no change in cerebral oxygenation. These transient changes are unlikely to cause harm.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/adc.2007.121715","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T21:09:02Z","timestamp":1202245742000},"page":"F261-F264","source":"Crossref","is-referenced-by-count":21,"title":["Cerebral blood volume changes during closure by surgery of patent ductus arteriosus"],"prefix":"10.1136","volume":"93","author":[{"given":"B 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