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Alteration of oxygen content may profoundly influence pulmonary vascular and ductus arteriosus responses. Interference in blood flow and oxygen content may affect cerebral development as a result of inadequate oxygen or energy substrate supply. The circulatory effects may be gestational dependent, related to maturation of vascular responses in different organs. These prenatal influences of congenital cardiac defects may severely affect immediate, as well as longterm, postnatal prognosis and survival. This has stimulated the development of techniques for palliation of disturbed circulation during fetal life.<\/jats:p>","DOI":"10.1136\/adc.2007.128777","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T20:34:51Z","timestamp":1238013291000},"page":"F132-F136","source":"Crossref","is-referenced-by-count":75,"title":["Congenital cardiovascular malformations and the fetal circulation"],"prefix":"10.1136","volume":"95","author":[{"given":"A M","family":"Rudolph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"2025090502135504000_95.2.F132.1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1542\/peds.36.5.763","article-title":"The effects of postnatal circulatory adjustments in congenital heart disease","volume":"36","author":"Rudolph","year":"1965","journal-title":"Pediatrics"},{"key":"2025090502135504000_95.2.F132.2","doi-asserted-by":"crossref","unstructured":"Rudolph AM . 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