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Diagnosis is difficult and often delayed, and this may contribute to the high levels of deep-organ dissemination and associated mortality and morbidity. The most commonly used antifungal agents are amphotericin B and fluconazole. Recent research has assessed the value of early empirical and prophylactic treatment. However, although systemic antifungal prophylaxis reduces the incidence of invasive fungal infection, there is no evidence of effect on mortality. Concern exists about the impact that widespread use of prophylaxis may have on the emergence of antifungal resistance.<\/jats:p>","DOI":"10.1136\/adc.2007.133769","type":"journal-article","created":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T20:33:47Z","timestamp":1223325227000},"page":"F65-F69","source":"Crossref","is-referenced-by-count":34,"title":["Prevention and treatment of invasive fungal infection in very low birthweight infants"],"prefix":"10.1136","volume":"94","author":[{"given":"M","family":"Brecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Clerihew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,10,6]]},"reference":[{"key":"2025090503474961000_94.1.F65.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"2025090503474961000_94.1.F65.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.12.004"},{"key":"2025090503474961000_94.1.F65.3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.082024"},{"key":"2025090503474961000_94.1.F65.4","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000202127.43695.06"},{"key":"2025090503474961000_94.1.F65.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1996"},{"key":"2025090503474961000_94.1.F65.6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.114504"},{"key":"2025090503474961000_94.1.F65.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"2025090503474961000_94.1.F65.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81375-7"},{"key":"2025090503474961000_94.1.F65.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1311"},{"key":"2025090503474961000_94.1.F65.10","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00011"},{"key":"2025090503474961000_94.1.F65.11","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2007.055"},{"key":"2025090503474961000_94.1.F65.12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2677"},{"key":"2025090503474961000_94.1.F65.13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.712"},{"key":"2025090503474961000_94.1.F65.14","doi-asserted-by":"publisher","DOI":"10.1136\/fnn.2006.097758"},{"key":"2025090503474961000_94.1.F65.15","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.3.756"},{"key":"2025090503474961000_94.1.F65.16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.438"},{"key":"2025090503474961000_94.1.F65.17","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.115865"},{"key":"2025090503474961000_94.1.F65.18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.634"},{"key":"2025090503474961000_94.1.F65.19","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200006000-00002"},{"key":"2025090503474961000_94.1.F65.20","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.188"},{"key":"2025090503474961000_94.1.F65.21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211628"},{"key":"2025090503474961000_94.1.F65.22","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199811000-00008"},{"key":"2025090503474961000_94.1.F65.23","doi-asserted-by":"crossref","unstructured":"Clerihew L McGuire W . 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