{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:16:09Z","timestamp":1784128569708,"version":"3.55.0"},"reference-count":16,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To study the epidemiology (including incidence, antibiotic sensitivity and mortality) of neonatal unit infections in countries in Asia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>One year prospective study of neonatal infections in eight neonatal units in Asia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>There were 453 episodes of sepsis affecting 394 babies. Mortality from neonatal sepsis was 10.4%, with an incidence of 0.69 deaths\/1000 live births. Group B streptococcus was the most common early-onset organism causing 38% of episodes of early-onset (&lt;48 h old) sepsis, with a rate of 0.51 episodes per 1000 live births and a mortality of 22%. Gram-negative bacillary early-onset sepsis occurred at a rate of 0.15 episodes per 1000 live births with a mortality of 12%. There were 406 episodes of late-onset sepsis. The incidence was high at 11.6 per 1000 live births, and mortality was 8.9%. Coagulase-negative staphylococcus caused 34.1% of episodes, whereas <jats:italic>Staphlococcus aureus<\/jats:italic> caused only 5.4%. Gram-negative bacilli caused 189 episodes (46.6%). Only 44% of Gram-negative bacilli were sensitive to both gentamicin and a third-generation cephalosporin, whereas 30% were resistant to both antibiotics. Meningitis occurred in 17.2% of episodes of late sepsis, with a mortality of 20%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The incidence of late-onset sepsis was higher in Asia than in resource-rich countries, but the organisms isolated and mortality were similar. Over half of all Gram-negative bacilli were antibiotic resistant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2008.139865","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T20:24:31Z","timestamp":1221855871000},"page":"F144-F148","source":"Crossref","is-referenced-by-count":71,"title":["Neonatal infections in Asia"],"prefix":"10.1136","volume":"94","author":[{"given":"R","family":"Tiskumara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Fakharee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Q","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Nuntnarumit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K M","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hammoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J K F","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C B","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Shenoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,9,19]]},"reference":[{"key":"2025090511415397000_94.2.F144.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71877-8"},{"key":"2025090511415397000_94.2.F144.2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.022863"},{"key":"2025090511415397000_94.2.F144.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71881-X"},{"key":"2025090511415397000_94.2.F144.4","first-page":"227","article-title":"Microbiological profile of neonatal septicemia in a pediatric care hospital in Delhi.","volume":"37","author":"Kapoor","year":"2005","journal-title":"J Commun Dis"},{"key":"2025090511415397000_94.2.F144.5","first-page":"449","article-title":"The etiology of neonatal sepsis and patterns of antibiotic resistance.","volume":"13","author":"Waheed","year":"2003","journal-title":"J Coll Physicians Surg Pak"},{"key":"2025090511415397000_94.2.F144.6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.5694\/j.1326-5377.1995.tb126024.x","article-title":"Systemic bacterial and fungal infections in infants in Australian neonatal units.","volume":"162","author":"Isaacs","year":"1995","journal-title":"Med J Aust"},{"key":"2025090511415397000_94.2.F144.7","doi-asserted-by":"crossref","unstructured":"Palazzi DL Klein JO Baker CJ . Bacterial sepsis and meningitis. In: Remington JS Klein JO Wilson CB , eds. Infectious diseases of the fetus and newborn infant. 6th edition. 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Group B streptococcal infections. In: Remington JS Klein JO Wilson CB , eds. Infectious diseases of the fetus and newborn infant. 6th edn. 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