{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:11:29Z","timestamp":1781082689117,"version":"3.54.1"},"reference-count":21,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The fetal inflammatory response syndrome involving proinflammatory cytokines such as interleukin-6 (IL-6) has been associated with cystic periventricular leukomalacia (cPVL). We evaluated whether the development of cPVL is associated with the IL-6 G(\u2212174)C polymorphism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>52 children with cPVL were compared to 46 preterm and 395 term controls using retrospective cohort analysis. IL-6 genotyping was performed using an allele specific polymerase chain reaction technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>IL-6 G(\u2212174)C polymorphisms did not differ between groups, but an association between mental retardation and the IL-6 C\/C (78%) and G\/C (43%) genotypes compared to the G\/G (25%) genotype was found (p\u200a=\u200a0.003 and 0.043, respectively; RR 3.11 (95% CI 1.54 to 6.29) and 1.79 (95% CI 1.10 to 2.92), respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The IL-6 (\u2212174) C\/C and G\/C genotypes were associated with mental retardation in cPVL and seem to modify the severity of perinatal brain injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/adc.2008.140244","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T20:29:27Z","timestamp":1232051367000},"page":"F304-F306","source":"Crossref","is-referenced-by-count":16,"title":["Interleukin-6 G(\u2212174)C polymorphism is associated with mental retardation in cystic periventricular leucomalacia in preterm infants"],"prefix":"10.1136","volume":"94","author":[{"given":"B","family":"Resch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Radinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Mannhalter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W D","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,1,15]]},"reference":[{"key":"2025090510484332000_94.4.F304.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199707000-00001","article-title":"Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn.","volume":"42","author":"Dammann","year":"1997","journal-title":"Pediatr Res"},{"key":"2025090510484332000_94.4.F304.2","doi-asserted-by":"crossref","first-page":"8034","DOI":"10.1523\/JNEUROSCI.22-18-08034.2002","article-title":"The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice.","volume":"22","author":"Parish","year":"2002","journal-title":"J Neurosci"},{"key":"2025090510484332000_94.4.F304.3","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI2629","article-title":"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.","volume":"102","author":"Fishman","year":"1998","journal-title":"J Clin Invest"},{"key":"2025090510484332000_94.4.F304.4","first-page":"62","article-title":"The promotor polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults.","volume":"12","author":"Kilpinen","year":"2002","journal-title":"Eur Cytokine Netw"},{"key":"2025090510484332000_94.4.F304.5","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.2144\/02335dd04","article-title":"Comparison of methods for determination of interleukin 6 G(\u00e2\u0088\u0092174)C promoter polymorphism.","volume":"33","author":"Haring","year":"2002","journal-title":"Biotechniques"},{"key":"2025090510484332000_94.4.F304.6","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008403"},{"key":"2025090510484332000_94.4.F304.7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.037309"},{"key":"2025090510484332000_94.4.F304.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-004-0223-9"},{"key":"2025090510484332000_94.4.F304.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2005.00524.x"},{"key":"2025090510484332000_94.4.F304.10","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.037531"},{"key":"2025090510484332000_94.4.F304.11","doi-asserted-by":"publisher","DOI":"10.1177\/107602960601200108"},{"key":"2025090510484332000_94.4.F304.12","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200201000-00005"},{"key":"2025090510484332000_94.4.F304.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0935-x"},{"key":"2025090510484332000_94.4.F304.14","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000112100.61253.85"},{"key":"2025090510484332000_94.4.F304.15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.4.800"},{"key":"2025090510484332000_94.4.F304.16","doi-asserted-by":"publisher","DOI":"10.1159\/000069484"},{"key":"2025090510484332000_94.4.F304.17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364264"},{"key":"2025090510484332000_94.4.F304.18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0494-F"},{"key":"2025090510484332000_94.4.F304.19","doi-asserted-by":"publisher","DOI":"10.2741\/1890"},{"key":"2025090510484332000_94.4.F304.20","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/00005373-200511000-00025","article-title":"Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications.","volume":"59","author":"Watanabe","year":"2005","journal-title":"J Trauma"},{"key":"2025090510484332000_94.4.F304.21","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000163523.49021.53"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2008.140244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T18:12:30Z","timestamp":1757095950000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2008.140244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,15]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,6,19]]},"published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1136\/adc.2008.140244"],"URL":"https:\/\/doi.org\/10.1136\/adc.2008.140244","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1148097.605218","asserted-by":"object"}]},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,15]]}}}