{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:16:19Z","timestamp":1769634979281,"version":"3.49.0"},"reference-count":17,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Invasive fungal infection is an important cause of mortality and morbidity in extremely preterm babies. Colonisation with <jats:italic>Candida<\/jats:italic> is a risk factor for systemic infection. A policy of oral nystatin prophylaxis was introduced in November 2000 with the aim of reducing the incidence of invasive fungaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim:<\/jats:title>\n                  <jats:p>To determine whether this policy had reduced the rates of fungal colonisation and invasive fungal infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>All neonates of &lt;33 weeks\u2019 gestation born between 1998 and 2003 were studied. Neonates born between January 1998 and October 2000 who did not receive nystatin prophylaxis (group A) were compared with those born between November 2000 and December 2003 who received nystatin prophylaxis (group B). Infant details, blood culture results and the results of weekly surface swabs were recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>1459 neonates (group A\u200a=\u200a724 , group B\u200a=\u200a735) of &lt;33 weeks\u2019 gestation were admitted in the study period. There were no differences in birth weight, gestation, gender or proportion of babies transferred in from other units between the groups. There was a reduction in colonisation from 257 (35.5%) in group A to 132 (18%) in group B. The incidence of invasive fungaemia decreased from 30 (4.1%) to 13 (1.8%) between the two groups. There was also a reduction in mortality between the two groups from 17.8% to 11.8%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The introduction of a prophylactic nystatin administration policy for babies born before 33 weeks was associated with a significant reduction in fungal colonisation and invasive fungal infection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2008.145359","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T20:25:17Z","timestamp":1227731117000},"page":"F275-F278","source":"Crossref","is-referenced-by-count":37,"title":["Prophylactic oral nystatin for preterm babies under 33 weeks\u2019 gestation decreases fungal colonisation and invasive fungaemia"],"prefix":"10.1136","volume":"94","author":[{"given":"K","family":"Ganesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Harigopal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Neal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C W","family":"Yoxall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"2025090512242997000_94.4.F275.1","doi-asserted-by":"crossref","unstructured":"Chapman RL . Prevention and treatment of candida infections in neonates. Semin Perinatol 2007;31;39\u00e2\u0080\u009346.","DOI":"10.1053\/j.semperi.2007.01.006"},{"key":"2025090512242997000_94.4.F275.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"2025090512242997000_94.4.F275.3","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00011"},{"key":"2025090512242997000_94.4.F275.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010494"},{"key":"2025090512242997000_94.4.F275.5","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.3.414"},{"key":"2025090512242997000_94.4.F275.6","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000226978.96218.e6"},{"key":"2025090512242997000_94.4.F275.7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1542\/peds.78.2.225","article-title":"Fungal colonization in the very low birth weight infant.","volume":"78","author":"Baley","year":"1986","journal-title":"Pediatrics"},{"key":"2025090512242997000_94.4.F275.8","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200112000-00005"},{"key":"2025090512242997000_94.4.F275.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.2.293"},{"key":"2025090512242997000_94.4.F275.10","doi-asserted-by":"publisher","DOI":"10.1080\/080352502317285216"},{"key":"2025090512242997000_94.4.F275.11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-2007-999649","article-title":"Prophylactic oral nystatin and fungal infections in very-low-birthweight infants.","volume":"5","author":"Sims","year":"1988","journal-title":"Am J Perinatol"},{"key":"2025090512242997000_94.4.F275.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01274.x"},{"key":"2025090512242997000_94.4.F275.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02136-X"},{"issue":"(Suppl 1)","key":"2025090512242997000_94.4.F275.14","first-page":"164","article-title":"Can we reduce antibiotic pressure on the tertiary neonatal unit? [Abstract]","volume":"165","author":"Stuwe","year":"2006","journal-title":"Eur J Pediatr"},{"key":"2025090512242997000_94.4.F275.15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-0714.1999.tb02007.x","article-title":"The in vitro post-antifungal effect of nystatin on Candida species of oral origin.","volume":"28","author":"Ellepola","year":"1999","journal-title":"J Oral Pathol Med"},{"key":"2025090512242997000_94.4.F275.16","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.1999.140605.x"},{"key":"2025090512242997000_94.4.F275.17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065733"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2008.145359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:24:37Z","timestamp":1757100277000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2008.145359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,6,19]]},"published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1136\/adc.2008.145359"],"URL":"https:\/\/doi.org\/10.1136\/adc.2008.145359","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}