{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:37:38Z","timestamp":1783420658925,"version":"3.54.6"},"reference-count":44,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec>\n                  <jats:title>Background and objective:<\/jats:title>\n                  <jats:p>Subependymal pseudocysts and choroid plexus cysts are seen in newborns on cerebral ultrasound. Clinicians are unsure whether these findings are related to an underlying disease which affects long-term outcome and requires medical intervention. In an attempt to establish the diagnostic value of cystic lesions on cerebral ultrasound and guide clinical management we searched the medical literature and performed a meta-analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We performed a systematic literature review and summarised the data on the value of subependymal pseudocysts or choroid plexus cysts for the diagnosis of chromosomal anomalies or congenital infections. Sensitivity, specificity, predictive values and likelihood ratios were calculated for single, multiple, unilateral and bilateral cysts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>305 patients with cystic lesions were retrieved. Bilateral cysts, irrespective of their number, had a sensitivity of 88% and negative predictive value of 94% for a congenital infection or genetic disorder. Unilateral single cysts had a specificity of 92% for normal microbiological and genetic results. Bilateral multiple subependymal pseudocysts or choroid plexus cysts had a positive likelihood ratio of 9.1 for a chromosomal anomaly or congenital infection. Unilateral cysts had a negative likelihood ratio of 0.2 for a congenital infection or chromosomal anomaly. There was a chance of 1 in 4\u20135 for a congenital infection or chromosomal anomaly if bilateral multiple subependymal pseudocysts or choroid plexus cysts were found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Bilateral multiple subependymal pseudocysts or choroid plexus cysts suggest an underlying disease. Further investigations should be undertaken even if the patient is otherwise normal. Parents of well newborns with a single cyst should be reassured.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2008.155028","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T20:34:51Z","timestamp":1238013291000},"page":"F443-F446","source":"Crossref","is-referenced-by-count":34,"title":["Diagnostic value of subependymal pseudocysts and choroid plexus cysts on neonatal cerebral ultrasound: a meta-analysis"],"prefix":"10.1136","volume":"94","author":[{"given":"J R","family":"Fernandez Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P N","family":"Amess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"2025090511550000000_94.6.F443.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.4.e41"},{"key":"2025090511550000000_94.6.F443.2","first-page":"178","article-title":"Congenital subependymal pseudocysts: own data and meta-analysis of the literature.","volume":"3","author":"Makhoul","year":"2001","journal-title":"Isr Med Assoc J"},{"key":"2025090511550000000_94.6.F443.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441403"},{"key":"2025090511550000000_94.6.F443.4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490420040003"},{"key":"2025090511550000000_94.6.F443.5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1651-2227.1993.tb12705.x","article-title":"Subependymal pseudocysts: ultrasound diagnosis and findings at follow-up.","volume":"82","author":"Rademaker","year":"1993","journal-title":"Acta Paediatr"},{"key":"2025090511550000000_94.6.F443.6","doi-asserted-by":"crossref","first-page":"F185","DOI":"10.1136\/fn.79.3.F185","article-title":"Incidence of cranial ultrasound abnormalities in apparantly well neonates on a postnatal ward: correlation with antenatal and perinatal factors and neurological status.","volume":"79","author":"Mercuri","year":"1998","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090511550000000_94.6.F443.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.034"},{"key":"2025090511550000000_94.6.F443.8","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807301924"},{"key":"2025090511550000000_94.6.F443.9","unstructured":"Health Protection Agency. Infectious Diseases. London: Health Protection Agency; 2005 (data updated 2008 February 12; cited 2008 November 14). Available from: http:\/\/www.hpa.org.uk (accessed 25 Jun 2009)."},{"key":"2025090511550000000_94.6.F443.10","unstructured":"EUROCAT Website Database. Ulster: University of Ulster; 2003 (data uploaded 2008 April 7; cited 2008 November 14). 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