{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:15:06Z","timestamp":1771046106277,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2010,5,31]]},"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the level of volume targeting (VT) associated with the lowest work of breathing (WOB) for prematurely born infants being ventilated with acute respiratory distress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Tertiary neonatal intensive care unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>18 infants, median gestational age 29 (range 25\u201334) weeks, being ventilated for acute respiratory distress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Infants were studied first without VT (baseline). Volume targeted levels of 4 ml\/kg, 5 ml\/kg and 6 ml\/kg were then delivered in random order. After each VT level, the infants were returned to baseline. Each step was maintained for 20 minutes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measure<\/jats:title>\n                  <jats:p>The transdiaphragmatic pressure time product (PTPdi) as an estimate of the WOB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean PTPdi was higher at a VT level of 4 ml\/kg (median 154 cm H<jats:sub>2<\/jats:sub>O\u00b7s\/min) compared to baseline (median 112 cm H<jats:sub>2<\/jats:sub>O\u00b7s\/min) (p&lt;0.001) and a VT level of 6 ml\/kg (median 89 cm H<jats:sub>2<\/jats:sub>O\u00b7s\/min) (p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A low level of VT increased the WOB in infants with acute respiratory distress syndrome. The authors' results suggest that, during acute respiratory distress, a VT level of at least 5 ml\/kg rather than a lower level might avoid an increased WOB. The most appropriate level of VT needs to be determined in a randomised controlled trial with long-term outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2009.176875","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T22:09:21Z","timestamp":1281046161000},"page":"F443-F446","source":"Crossref","is-referenced-by-count":19,"title":["Work of breathing and volume targeted ventilation in respiratory distress"],"prefix":"10.1136","volume":"95","author":[{"given":"Deena-Shefali","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrard F","family":"Rafferty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Hannam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,8,5]]},"reference":[{"key":"2025090512020245000_95.6.F443.1","doi-asserted-by":"crossref","unstructured":"McCallion N Davis P Morley C . Volume-targeted versus pressure-limited ventilation in the neonate. 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