{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:09:46Z","timestamp":1785499786394,"version":"3.56.0"},"reference-count":29,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2010,4,22]]},"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A haemodynamically important patent ductus arteriosus (PDA) is a risk factor for brain damage in preterm infants. The authors previously reported lower regional cerebral oxygen saturation (rScO<jats:sub>2<\/jats:sub>) in infants with PDA, which recovered after administration of indomethacin. However, PDA ligation has been reported to pose an even higher risk of neurodevelopmental impairment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the impact of surgical closure of PDA on rScO<jats:sub>2<\/jats:sub> and cerebral fractional tissue oxygen extraction (cFTOE), measured by near-infrared spectroscopy, and on amplitude-integrated electro-encephalography (aEEG) measured brain activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design\/methods<\/jats:title>\n                  <jats:p>In 20 preterm infants (gestational age 24.7\u201330.4 weeks; birth weight 630\u20131540 g), blood pressure, arterial saturation, rScO<jats:sub>2<\/jats:sub>, cFTOE and aEEG were monitored before, during and up to 24 h after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Before surgery, median (range) rScO<jats:sub>2<\/jats:sub> was 53% (41\u201368%), and during surgery, but before ductal clipping, it was 46% (31\u201389%). Eleven infants showed a drop in blood pressure and 13 infants a drop in rScO<jats:sub>2<\/jats:sub> during surgery (range 2\u201321%), accompanied by a decrease in aEEG amplitude. Twelve infants had rScO<jats:sub>2<\/jats:sub> values below 50% during surgery, with five being below 40%. Only at 24 h after surgery was rScO<jats:sub>2<\/jats:sub> higher (61% (36\u201385%), p&lt;0.05) and cFTOE values lower (0.38 (0.09\u20130.61); p&lt;0.05) compared with preclipping values.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Ductal ligation poses a risk for a further decrease in already compromised cerebral oxygenation in preterm infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2009.180117","type":"journal-article","created":{"date-parts":[[2010,6,28]],"date-time":"2010-06-28T23:44:57Z","timestamp":1277768697000},"page":"F429-F434","source":"Crossref","is-referenced-by-count":71,"title":["Is cerebral oxygen supply compromised in preterm infants undergoing surgical closure for patent ductus arteriosus?"],"prefix":"10.1136","volume":"95","author":[{"given":"Petra M A","family":"Lemmers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella C","family":"Molenschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jola","family":"Evens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona C","family":"Toet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,6,28]]},"reference":[{"key":"2025090512132203000_95.6.F429.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1522"},{"key":"2025090512132203000_95.6.F429.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2418"},{"key":"2025090512132203000_95.6.F429.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2006.10.004"},{"key":"2025090512132203000_95.6.F429.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2781"},{"key":"2025090512132203000_95.6.F429.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0925"},{"key":"2025090512132203000_95.6.F429.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80662-6"},{"key":"2025090512132203000_95.6.F429.7","first-page":"802","article-title":"Cerebral blood flow velocity changes in preterm infants after a single dose of indomethacin: duration of its effect","volume-title":"Pediatrics","volume":"84:","author":"Van Bel","year":"1989"},{"key":"2025090512132203000_95.6.F429.8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3124"},{"key":"2025090512132203000_95.6.F429.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83391-8"},{"key":"2025090512132203000_95.6.F429.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70060-X"},{"key":"2025090512132203000_95.6.F429.11","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50086"},{"key":"2025090512132203000_95.6.F429.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.11.039"},{"key":"2025090512132203000_95.6.F429.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2006.02209.x"},{"key":"2025090512132203000_95.6.F429.14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955941"},{"key":"2025090512132203000_95.6.F429.15","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.121715"},{"key":"2025090512132203000_95.6.F429.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01021.x"},{"key":"2025090512132203000_95.6.F429.17","doi-asserted-by":"publisher","DOI":"10.1159\/000063609"},{"key":"2025090512132203000_95.6.F429.18","doi-asserted-by":"publisher","DOI":"10.1159\/000151642"},{"key":"2025090512132203000_95.6.F429.19","doi-asserted-by":"publisher","DOI":"10.1159\/000101063"},{"key":"2025090512132203000_95.6.F429.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90467-8"},{"key":"2025090512132203000_95.6.F429.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2008.07.017"},{"key":"2025090512132203000_95.6.F429.22","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2300-3"},{"key":"2025090512132203000_95.6.F429.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(02)00018-0"},{"key":"2025090512132203000_95.6.F429.24","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.108947"},{"key":"2025090512132203000_95.6.F429.25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.625"},{"key":"2025090512132203000_95.6.F429.26","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/28\/10\/010"},{"key":"2025090512132203000_95.6.F429.27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200502-230OC"},{"key":"2025090512132203000_95.6.F429.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.01.035"},{"key":"2025090512132203000_95.6.F429.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80366-7"}],"container-title":["Archives of Disease in Childhood - 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