{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:27:48Z","timestamp":1787506068489,"version":"build-2736575974"},"reference-count":26,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2010,5,20]]},"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy of oral sucrose combined with swaddling and non-nutritive suck (NNS) as a method for reducing pain associated with retinopathy of prematurity (ROP) screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomised placebo controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary level neonatal intensive care unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sample<\/jats:title>\n                    <jats:p>40 infants undergoing primary eye examination for ROP screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>The control group were swaddled, and received 0.2 ml of sterile water given by mouth using a syringe and a soother. The intervention group were swaddled, and received 0.2 ml of sucrose 24% given by mouth using a syringe and a soother.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>40 infants were included in the study. There was no difference in mean gestational age at birth, mean birth weight or corrected gestational age at first examination between both groups. The sucrose group had a significantly lower median Neonatal Pain, Agitation and Sedation Scale (N-PASS) score during ROP screening, initially following insertion of the speculum (6.5 vs 5, p=0.02) and subsequently during scleral indentation (9.5 vs 7.5, p=0.03). Fewer infants experienced episodes of desaturations or bradycardia in the intervention group (1 vs 4, p=0.18).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ROP screening is a necessary but recognised painful procedure. Sucrose combined with NNS and swaddling reduced the behavioural and physiological pain responses. However, pain scores remained consistently high and appropriate pain relief for ROP screening remains a challenge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/adc.2009.180943","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T20:24:11Z","timestamp":1285705451000},"page":"F419-F422","source":"Crossref","is-referenced-by-count":46,"title":["Sweeten, soother and swaddle for retinopathy of prematurity screening: a randomised placebo controlled trial"],"prefix":"10.1136","volume":"95","author":[{"given":"A","family":"O'Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Brosnahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"McCreery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,9,28]]},"reference":[{"key":"2025090513015192000_95.6.F419.1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.10-1-e20"},{"key":"2025090513015192000_95.6.F419.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.2.273"},{"key":"2025090513015192000_95.6.F419.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14631-4"},{"key":"2025090513015192000_95.6.F419.4","unstructured":"Royal College of Paediatrics and Child Health, Royal College of Ophthalmologists and the British Association of Perinatal Medicine. UK Retinopathy of Prematurity Guidelines, 2007."},{"key":"2025090513015192000_95.6.F419.5","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.155.2.173"},{"key":"2025090513015192000_95.6.F419.6","unstructured":"Anand KJS . The biology of pain perception in newborn infants. In: Tyler DC Kane EJ , eds. Advances in pain research therapy, 15th edn. New York: Raven Press, 1990;113\u201322."},{"key":"2025090513015192000_95.6.F419.7","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0031-3955(16)36722-0","article-title":"The neuroanatomy, neurophysiology, and neurochemistry of pain, stress, and analgesia in newborns and children","volume":"36","author":"Anand","year":"1989","journal-title":"Pediatr Clin North Am"},{"key":"2025090513015192000_95.6.F419.8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.1.105"},{"key":"2025090513015192000_95.6.F419.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(02)00012-X"},{"key":"2025090513015192000_95.6.F419.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.01.014"},{"key":"2025090513015192000_95.6.F419.11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1155\/2001\/376819","article-title":"Mechanisms of sucrose and non-nutritive sucking in procedural pain management in infants","volume":"6","author":"Gibbins","year":"2001","journal-title":"Pain Res Manag"},{"key":"2025090513015192000_95.6.F419.12","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/20.1.29"},{"key":"2025090513015192000_95.6.F419.13","doi-asserted-by":"crossref","unstructured":"Pinelli J Symington A . Non-nutritive sucking for promoting physiologic stability and nutrition in preterm infants. Cochrane Database Syst Rev 2005;4:CD001071.","DOI":"10.1002\/14651858.CD001071.pub2"},{"key":"2025090513015192000_95.6.F419.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1088-145X.2005.00002.x"},{"key":"2025090513015192000_95.6.F419.15","doi-asserted-by":"crossref","unstructured":"Stevens B Yamada J Ohlsson A . Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev 2004;3:CD001069.","DOI":"10.1002\/14651858.CD001069.pub2"},{"key":"2025090513015192000_95.6.F419.16","unstructured":"Pritchard D . Reducing pain during blood sampling in infants. Clin Evid 2001;(7):529\u201344."},{"key":"2025090513015192000_95.6.F419.17","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E477"},{"key":"2025090513015192000_95.6.F419.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2004.06.001"},{"key":"2025090513015192000_95.6.F419.19","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.087668"},{"key":"2025090513015192000_95.6.F419.20","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200501000-00008"},{"key":"2025090513015192000_95.6.F419.21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211199"},{"key":"2025090513015192000_95.6.F419.22","unstructured":"Walden M . Pain Assessment and Management: Guidelines for Practice. Document 1222. National Association of Neonatal Nurses, 2001."},{"key":"2025090513015192000_95.6.F419.23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211861"},{"key":"2025090513015192000_95.6.F419.24","doi-asserted-by":"crossref","unstructured":"Hummel P Lawlor-Klean P Weiss MG . Validity and reliability of the N_PASS assessment tool with acute pain. J Perinatol.Published Online First: 19 November 2009. doi: 10.1038\/jp.2009.185","DOI":"10.1038\/jp.2009.185"},{"key":"2025090513015192000_95.6.F419.25","doi-asserted-by":"publisher","DOI":"10.1159\/000079542"},{"key":"2025090513015192000_95.6.F419.26","unstructured":"Field T . Sucking and massage therapy reduce stress during infancy. In: Lewis M Ramsey D , eds. Soothing and stress. New Jersey: Lawrence Erlbaum Associates, 1999:157\u201369."}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2009.180943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:02:09Z","timestamp":1757102529000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2009.180943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,28]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,10,26]]},"published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1136\/adc.2009.180943"],"URL":"https:\/\/doi.org\/10.1136\/adc.2009.180943","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,28]]}}}