{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:35:16Z","timestamp":1789205716773,"version":"build-2803163510"},"reference-count":5,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2010,4,3]]},"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Early continuous positive airway pressure (CPAP) may reduce lung injury in preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and methods<\/jats:title>\n                  <jats:p>Spontaneously breathing preterm infants were randomised immediately after birth to nasal CPAP or intubation, surfactant treatment and mechanical ventilation. Pulmonary function tests approximately 8 weeks post-term determined tidal breathing parameters, respiratory mechanics and functional residual capacity (FRC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventeen infants received CPAP and 22 mechanical ventilation. Infants with early CPAP had less mechanical ventilation (4 vs 7.5 days; p=0.004) and less total respiratory support (30 vs 47 days; p=0.017). Post-term the CPAP group had lower respiratory rate (41 vs 48\/min; p=0.007), lower minute ventilation (223 vs 265 ml\/min\/kg; p=0.009), better respiratory compliance (0.99 vs 0.82 ml\/cm H<jats:sub>2<\/jats:sub>O\/kg; p=0.008) and improved elastic work of breathing (p=0.004). No differences in FRC were found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Early CPAP is feasible, shortens the duration of respiratory support and results in improved lung mechanics and decreased work of breathing.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2009.181008","type":"journal-article","created":{"date-parts":[[2010,6,28]],"date-time":"2010-06-28T23:44:57Z","timestamp":1277768697000},"page":"F371-F373","source":"Crossref","is-referenced-by-count":34,"title":["Positive effects of early continuous positive airway pressure on pulmonary function in extremely premature infants: results of a subgroup analysis of the COIN trial"],"prefix":"10.1136","volume":"96","author":[{"given":"C C","family":"Roehr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Proquitt\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R R","family":"Wauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Morley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Schmalisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,6,28]]},"reference":[{"key":"2025090512503452000_96.5.F371.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.082271"},{"key":"2025090512503452000_96.5.F371.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072788"},{"key":"2025090512503452000_96.5.F371.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00931.x"},{"key":"2025090512503452000_96.5.F371.4","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318189487e"},{"key":"2025090512503452000_96.5.F371.5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199902)27:2<104::AID-PPUL6>3.0.CO;2-T"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2009.181008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:50:43Z","timestamp":1757101843000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2009.181008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,28]]},"references-count":5,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,8,11]]},"published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1136\/adc.2009.181008"],"URL":"https:\/\/doi.org\/10.1136\/adc.2009.181008","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,28]]}}}