{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:42:25Z","timestamp":1787236945279,"version":"build-2736575974"},"reference-count":46,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2010,6,2]]},"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>The breastfed infant with prolonged unconjugated hyperbilirubinaemia can present a vexing clinical dilemma. Although it is a frequently observed and usually benign finding, prolonged jaundice in the breastfed newborn requires a thoughtful evaluation that excludes possible pathological aetiologies. While recommendations for the treatment of unconjugated hyperbilirubinaemia in the first 7 days of life are straightforward, the approach to the breastfeeding infant with jaundice that persists beyond the immediate neonatal period is less clearly delineated. A sound understanding of bilirubin physiology and familiarity with current literature must guide the management of the otherwise well breastfeeding infant with prolonged unconjugated hyperbilirubinaemia.<\/jats:p>","DOI":"10.1136\/adc.2010.184416","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T22:09:21Z","timestamp":1281046161000},"page":"F461-F466","source":"Crossref","is-referenced-by-count":53,"title":["Understanding and managing breast milk jaundice"],"prefix":"10.1136","volume":"96","author":[{"given":"Genevieve L","family":"Preer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L","family":"Philipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,8,5]]},"reference":[{"key":"2025090511564597000_96.6.F461.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80422-5"},{"key":"2025090511564597000_96.6.F461.2","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1542\/peds.32.6.995","article-title":"Hyperbilirubinemia in breast-fed infants","volume":"32","author":"Newman","year":"1963","journal-title":"Pediatrics"},{"key":"2025090511564597000_96.6.F461.3","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1965.02090020214003"},{"key":"2025090511564597000_96.6.F461.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82162-6"},{"key":"2025090511564597000_96.6.F461.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2491"},{"key":"2025090511564597000_96.6.F461.6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1542\/pir.15.11.422","article-title":"Neonatal jaundice","volume":"15","author":"Gartner","year":"1994","journal-title":"Pediatr Rev"},{"key":"2025090511564597000_96.6.F461.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.297"},{"key":"2025090511564597000_96.6.F461.8","doi-asserted-by":"publisher","DOI":"10.1042\/bj1840705"},{"key":"2025090511564597000_96.6.F461.9","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1990.02150270114039"},{"key":"2025090511564597000_96.6.F461.10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955528"},{"key":"2025090511564597000_96.6.F461.11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0140-6736(86)91724-1","article-title":"beta-Glucuronidase and hyperbilirubinaemia in breast-fed and formula-fed babies","volume":"1","author":"Gourley","year":"1986","journal-title":"Lancet"},{"key":"2025090511564597000_96.6.F461.12","first-page":"435","article-title":"Free fatty acids in the development of breast milk jaundice","volume":"4","author":"Jalili","year":"1985","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025090511564597000_96.6.F461.13","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1203\/00006450-198012000-00011","article-title":"High milk lipase activity associated with breast milk jaundice","volume":"14","author":"Poland","year":"1980","journal-title":"Pediatr Res"},{"key":"2025090511564597000_96.6.F461.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80429-6"},{"key":"2025090511564597000_96.6.F461.15","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181ac4a30"},{"key":"2025090511564597000_96.6.F461.16","unstructured":"Beutler E . Disorders of red cells resulting from enzyme abnormalities. In: Lichtman MA Beutler E Kipps TJ Seligsohn U Prchal J , eds. Williams hematology. 7th edn. New York: The McGraw-Hill Companies Incorporated, 2006:603\u201331."},{"key":"2025090511564597000_96.6.F461.17","unstructured":"Gallagher PG . Disorders of the red blood cell membrane: hereditary spherocytosis, elliptocytosis, and related disorders. In: Lichtman MA Beutler E Kipps TJ Seligsohn U Prchal J , eds. Williams hematology. 7th edn. New York: McGraw-Hill, 2006:571\u2013601."},{"key":"2025090511564597000_96.6.F461.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.12.005"},{"key":"2025090511564597000_96.6.F461.19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.7205\/MILMED.171.9.905","article-title":"Prevalence of glucose-6-phosphate dehydrogenase deficiency in U.S. army personnel","volume":"171","author":"Chinevere","year":"2006","journal-title":"Mil Med"},{"key":"2025090511564597000_96.6.F461.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60073-2"},{"key":"2025090511564597000_96.6.F461.21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1542\/peds.97.5.707","article-title":"Henna: a potential cause of oxidative hemolysis and neonatal hyperbilirubinemia","volume":"97","author":"Zinkham","year":"1996","journal-title":"Pediatrics"},{"key":"2025090511564597000_96.6.F461.22","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.211"},{"key":"2025090511564597000_96.6.F461.23","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","article-title":"G6PD deficiency","volume":"84","author":"Beutler","year":"1994","journal-title":"Blood"},{"key":"2025090511564597000_96.6.F461.24","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.216"},{"key":"2025090511564597000_96.6.F461.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80442-1"},{"key":"2025090511564597000_96.6.F461.26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0168-8278(02)00359-8","article-title":"Inherited disorders of bilirubin metabolism","volume":"38","author":"Bosma","year":"2003","journal-title":"J Hepatol"},{"key":"2025090511564597000_96.6.F461.27","unstructured":"Wolkoff AW . The hyperbilirubinemias. In: Fauci AS Braunwald E Kasper DL Hauser SL Longo DL Jameson JL Loscalzo J , eds. Harrison's principles of internal medicine. 17th edn. New York: McGraw-Hill, 2008:1927\u201331."},{"key":"2025090511564597000_96.6.F461.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70356-7"},{"key":"2025090511564597000_96.6.F461.29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1651-2227.2002.tb01650.x","article-title":"Presence of the genetic marker for Gilbert syndrome is associated with increased level and duration of neonatal jaundice","volume":"91","author":"Roy-Chowdhury","year":"2002","journal-title":"Acta Paediatr"},{"key":"2025090511564597000_96.6.F461.30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.22.12128"},{"key":"2025090511564597000_96.6.F461.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02610-6"},{"key":"2025090511564597000_96.6.F461.32","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1182\/blood.V91.3.1093","article-title":"UGT1 promoter polymorphism accounts for increased neonatal appearance of hereditary spherocytosis","volume":"91","author":"Iolascon","year":"1998","journal-title":"Blood"},{"key":"2025090511564597000_96.6.F461.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70201-5"},{"key":"2025090511564597000_96.6.F461.34","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.5.e59"},{"key":"2025090511564597000_96.6.F461.35","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0382-0"},{"key":"2025090511564597000_96.6.F461.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80963-8"},{"key":"2025090511564597000_96.6.F461.37","doi-asserted-by":"publisher","DOI":"10.1136\/adc.47.253.469"},{"key":"2025090511564597000_96.6.F461.38","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000183372.23726.ca"},{"key":"2025090511564597000_96.6.F461.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80192-5"},{"key":"2025090511564597000_96.6.F461.40","first-page":"873","article-title":"Ceftriaxone effect on bilirubin-albumin binding","volume":"80","author":"Fink","year":"1987","journal-title":"Pediatrics"},{"key":"2025090511564597000_96.6.F461.41","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1128\/AAC.32.10.1571","article-title":"In vitro displacement of bilirubin by antibiotics and 2-hydroxybenzoylglycine in newborns","volume":"32","author":"Wadsworth","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"2025090511564597000_96.6.F461.42","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1542\/peds.91.6.1203","article-title":"Newborn screening for congenital hypothyroidism: recommended guidelines","volume":"91","author":"American Academy of Pediatrics AAP Section on Endocrinology and Committee on Genetics; American Thyroid Association Committee on Public Health","year":"1993","journal-title":"Pediatrics"},{"key":"2025090511564597000_96.6.F461.43","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.5.846"},{"key":"2025090511564597000_96.6.F461.44","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.5.1213"},{"key":"2025090511564597000_96.6.F461.45","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.5.1212"},{"key":"2025090511564597000_96.6.F461.46","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210629"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2010.184416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:07:12Z","timestamp":1757099232000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2010.184416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,5]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,10,12]]},"published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1136\/adc.2010.184416"],"URL":"https:\/\/doi.org\/10.1136\/adc.2010.184416","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,5]]}}}