{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:49:33Z","timestamp":1780595373506,"version":"3.54.1"},"reference-count":25,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2011,1,6]]},"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>International guidelines recommend a compression to ventilation (C:V) ratio of 3:1 in neonates, and 15:2 for other paediatric age groups. The authors aimed to compare these two C:V ratios in a neonatal swine model of cardiac arrest following asphyxia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Experimental animal study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Facility for animal research.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects<\/jats:title>\n                  <jats:p>22 newborn pigs (age 12\u201336 h, weight 2.0\u20132.7 kg).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Progressive asphyxia until asystole. Animals were randomised to receive C:V 3:1 (n=11) or 15:2 (n=11).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Return of spontaneous circulation (ROSC) was defined as a heart rate \u2265100 bpm. Also of interest were haemodynamic parameters, cerebral and systemic oxygen saturation and the proinflammatory cytokine interleukin-1\u03b2 (IL-1\u03b2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two animals in each group did not achieve ROSC. Mean (SD) increase in diastolic blood pressure (DBP; mm Hg) during compression cycles was significantly higher at a C:V ratio of 15:2 than 3:1 (7.1 (2.8) vs 4.8 (2.6)). Median time (IQR) to ROSC for the 3:1 group was 150 (140\u2013180) s, and 195 (145\u2013358) s for the 15:2 group. There were no significant differences in the temporal changes in haemodynamic parameters or oxygen saturation indices between the groups. IL-1\u03b2 levels in cerebrospinal and bronchoalveolar lavage fluid was comparable between the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In neonatal pigs with asphyxia-induced cardiac arrest, the response to a C:V ratio of 15:2 is not better than the response to a C:V ratio of 3:1 despite better generation of DBP during resuscitation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2010.200386","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T20:35:48Z","timestamp":1299789348000},"page":"F417-F421","source":"Crossref","is-referenced-by-count":91,"title":["Return of spontaneous circulation with a compression:ventilation ratio of 15:2 versus 3:1 in newborn pigs with cardiac arrest due to asphyxia"],"prefix":"10.1136","volume":"96","author":[{"given":"Anne L","family":"Solev\u00e5g","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Dannevig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra","family":"Wyckoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola D","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Nakstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,3,10]]},"reference":[{"key":"2025090221385542000_96.6.F417.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971127"},{"key":"2025090221385542000_96.6.F417.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971119"},{"key":"2025090221385542000_96.6.F417.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2008.01.001"},{"key":"2025090221385542000_96.6.F417.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.711820"},{"key":"2025090221385542000_96.6.F417.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000163651.57730.73"},{"key":"2025090221385542000_96.6.F417.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80261-8"},{"key":"2025090221385542000_96.6.F417.7","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.102963"},{"key":"2025090221385542000_96.6.F417.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(98)00141-5"},{"key":"2025090221385542000_96.6.F417.9","doi-asserted-by":"publisher","DOI":"10.1161\/hc4501.098926"},{"key":"2025090221385542000_96.6.F417.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2003.12.024"},{"key":"2025090221385542000_96.6.F417.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971093"},{"key":"2025090221385542000_96.6.F417.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.06.007"},{"key":"2025090221385542000_96.6.F417.13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0987"},{"key":"2025090221385542000_96.6.F417.14","doi-asserted-by":"publisher","DOI":"10.1159\/000275560"},{"key":"2025090221385542000_96.6.F417.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2003.12.001"},{"key":"2025090221385542000_96.6.F417.16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.711820"},{"key":"2025090221385542000_96.6.F417.17","doi-asserted-by":"publisher","DOI":"10.1542\/neo.11-3-e123"},{"key":"2025090221385542000_96.6.F417.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cupe.2004.12.002"},{"key":"2025090221385542000_96.6.F417.19","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000161621.74554.15"},{"key":"2025090221385542000_96.6.F417.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(02)00054-0"},{"key":"2025090221385542000_96.6.F417.21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0219"},{"key":"2025090221385542000_96.6.F417.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.04.026"},{"key":"2025090221385542000_96.6.F417.23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000126594.79136.61"},{"key":"2025090221385542000_96.6.F417.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2004.10.009"},{"key":"2025090221385542000_96.6.F417.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.02.001"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2010.200386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:39:04Z","timestamp":1756874344000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/adc.2010.200386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,10]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,10,12]]},"published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1136\/adc.2010.200386"],"URL":"https:\/\/doi.org\/10.1136\/adc.2010.200386","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,10]]}}}