{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:10Z","timestamp":1777417090888,"version":"3.51.4"},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child"],"accepted":{"date-parts":[[2011,3,10]]},"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Opsoclonus-myoclonus syndrome (OMS) is a serious, often disabling neurological illness of early childhood which is frequently associated with occult neuroblastoma. As investigation methods vary significantly, the authors assessed the usefulness of imaging and metabolic studies in tumour detection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective case note review of 101 OMS patients from two paediatric neurology centres over 53 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of neuroblastoma in OMS was 8% in the 1970s, 16% in the 1980s, 38% in the 1990s and 43% in the 2000s, with tumours being mainly low grade. CT\/MR imaging of the chest and abdomen was the most accurate test to detect occult neuroblastoma. Poorer sensitivities were noted for metaiodobenzylguanidine scintigraphy and urine catecholamines, reflecting the low metabolic activity of these tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CT\/MR imaging has the highest detection rate of neuroblastoma and this should be reflected in investigation protocols to achieve the best possible outcome for children with OMS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2010.204792","type":"journal-article","created":{"date-parts":[[2011,4,3]],"date-time":"2011-04-03T20:13:22Z","timestamp":1301861602000},"page":"461-463","source":"Crossref","is-referenced-by-count":60,"title":["Investigating neuroblastoma in childhood opsoclonus-myoclonus syndrome"],"prefix":"10.1136","volume":"97","author":[{"given":"Andreas","family":"Brunklaus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Pohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer M","family":"Zuberi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,4,3]]},"reference":[{"key":"2025101602102436000_97.5.461.1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/(SICI)1096-911X(199704)28:4<284::AID-MPO7>3.0.CO;2-E","article-title":"Long-term neurologic outcome in children with opsoclonus-myoclonus associated with neuroblastoma: a report from the Pediatric Oncology Group.","volume":"28","author":"Russo","year":"1997","journal-title":"Med Pediatr Oncol"},{"key":"2025101602102436000_97.5.461.2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/1043454204272560","article-title":"Neuroepidemiologic trends in 105 US cases of pediatric opsoclonus-myoclonus syndrome.","volume":"22","author":"Tate","year":"2005","journal-title":"J Pediatr Oncol Nurs"},{"key":"2025101602102436000_97.5.461.3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ejpn.2009.12.005","article-title":"Opsoclonus-myoclonus in children associated or not with neuroblastoma.","volume":"14","author":"Krug","year":"2010","journal-title":"Eur J Paediatr Neurol"},{"key":"2025101602102436000_97.5.461.4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1542\/peds.109.1.86","article-title":"Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae.","volume":"109","author":"Mitchell","year":"2002","journal-title":"Pediatrics"},{"key":"2025101602102436000_97.5.461.5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF01953945","article-title":"Neurological sequelae of the dancing eye syndrome.","volume":"155","author":"Pohl","year":"1996","journal-title":"Eur J Pediatr"},{"key":"2025101602102436000_97.5.461.6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpn.2009.03.002","article-title":"A prospective study of the presentation and management of dancing eye syndrome\/opsoclonus-myoclonus syndrome in the United Kingdom.","volume":"14","author":"Pang","year":"2010","journal-title":"Eur J Paediatr Neurol"},{"key":"2025101602102436000_97.5.461.7","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/1097-0142(19940915)74:6<1821::AID-CNCR2820740627>3.0.CO;2-A","article-title":"Poor outcome in patients with advanced stage neuroblastoma and coincident opsomyoclonus syndrome.","volume":"74","author":"Hiyama","year":"1994","journal-title":"Cancer"},{"key":"2025101602102436000_97.5.461.8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/1096-911X(200008)35:2<153::AID-MPO18>3.0.CO;2-7","article-title":"False-negative metaiodobenzylguanidine scintigraphy at diagnosis of neuroblastoma.","volume":"35","author":"Biasotti","year":"2000","journal-title":"Med Pediatr Oncol"},{"key":"2025101602102436000_97.5.461.9","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1212\/WNL.62.9.1526","article-title":"B- and T-cell markers in opsoclonus-myoclonus syndrome: immunophenotyping of CSF lymphocytes.","volume":"62","author":"Pranzatelli","year":"2004","journal-title":"Neurology"},{"key":"2025101602102436000_97.5.461.10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00383-003-1070-x","article-title":"Neuroblastoma detected by mass screening: the Tumor Board's role in its treatment.","volume":"20","author":"Okazaki","year":"2004","journal-title":"Pediatr Surg Int"},{"key":"2025101602102436000_97.5.461.11","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3109\/02841859909175580","article-title":"Imaging of abdominal neuroblastoma in children.","volume":"40","author":"Hugosson","year":"1999","journal-title":"Acta Radiol"},{"key":"2025101602102436000_97.5.461.12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s002470050123","article-title":"Thoracic neuroblastoma: what is the best imaging modality for evaluating extent of disease?","volume":"27","author":"Slovis","year":"1997","journal-title":"Pediatr Radiol"},{"key":"2025101602102436000_97.5.461.13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1148\/radiol.2231010841","article-title":"Staging of neuroblastoma at imaging: report of the radiology diagnostic oncology group.","volume":"223","author":"Siegel","year":"2002","journal-title":"Radiology"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.2010.204792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:11:08Z","timestamp":1760605868000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.2010.204792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,3]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,4,22]]},"published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1136\/adc.2010.204792"],"URL":"https:\/\/doi.org\/10.1136\/adc.2010.204792","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,3]]}}}