{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:52:28Z","timestamp":1773280348532,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2011,4,19]]},"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine morbidity, mortality and associated risk factors following patent ductus arteriosus (PDA) ligation in premature infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective case note audit of premature infants referred to a national paediatric cardiothoracic surgical service (2001\u20132007) with univariate and multivariate analysis of potential risk factors for mortality and morbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>125 infants were enrolled (median gestational age 26 weeks (IQR 25\u201327 weeks), median birth weight 840 g (IQR 730\u20131035 g)). Referral characteristics were median LA:Ao 1.8 (IQR 1.5\u20132.0), 80% ventilated, 18.4% continuous positive airway pressure, 70% diuretics and 58% prior treatment with cyclooxygenase inhibitors (COIs). Median age at PDA ligation was 31 days (IQR 25\u201341 days). Postoperative characteristics were median time to extubation 5 days (IQR 3\u201310 days), 36.0% corticosteroids, 46.8% domiciliary oxygen and 4.8% vocal cord palsy. The 30-day and 1-year mortality rates were 4.8% and 12.8%, respectively, with neurodisability in 32% of survivors. All deaths occurred in the ventilated group and were mainly attributable to bronchopulmonary dysplasia (BPD). Gestation and fractional inspired oxygen (FiO<jats:sub>2<\/jats:sub>)&gt;60% were significantly associated with 30-day mortality. FiO<jats:sub>2<\/jats:sub>, ventilation, lack of prior COIs and postoperative corticosteroids were significantly associated with 1-year mortality. Preoperative FiO<jats:sub>2<\/jats:sub>&gt;40% and lack of prior COIs retained independent significance for death at 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PDA ligation is well tolerated, with evidence of early benefit. The incidence of neurodisability or death from BPD at 1 year remains high. Increasing preoperative FiO<jats:sub>2<\/jats:sub> and lack of prior treatment with COIs are associated with increased mortality at 1 year.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2010.206052","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T20:19:32Z","timestamp":1313698772000},"page":"F39-F44","source":"Crossref","is-referenced-by-count":29,"title":["Outcomes following the surgical ligation of the patent ductus arteriosus in premature infants in Scotland"],"prefix":"10.1136","volume":"97","author":[{"given":"Anne Marie","family":"Heuchan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,8,17]]},"reference":[{"key":"2025090510153078000_97.1.F39.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.092734"},{"key":"2025090510153078000_97.1.F39.2","unstructured":"Weffers B Heuchan AM . A national survey of treatment of PDA in infants <30 weeks gestation. 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