{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:21:29Z","timestamp":1779164489746,"version":"3.51.4"},"reference-count":36,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2011,6,30]]},"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Oral ibuprofen has been shown to be associated with excellent patent ductus arteriosus (PDA) closure rates and a favourable safety profile, but limited data exist regarding its pharmacokinetics in preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate pharmacokinetic parameters of oral ibuprofen in preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Plasma ibuprofen levels were determined at various time points, and pharmacokinetic profiles were calculated after a single dose of 10 mg\/kg of oral ibuprofen. The rate of ductal closure, adverse effects and patients' clinical course were recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The authors studied 13 preterm infants (mean gestational age\u00b1SD 27.8\u00b12.4 weeks, mean birth weight 1052\u00b1443 g). PDA closure was obtained in all patients after a single dose. Ibuprofen levels were detectable 1 h after administration, peaked after 8 h and remained in a relative plateau until 24 h postadministration. Area under the curve (AUC)0\u219224 was higher than levels reported with intravenous treatment. No adverse effects were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Oral administration of ibuprofen in very preterm infants is associated with excellent absorption and a high AUC0\u219224, and may be an alternative to intravenous administration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/adc.2011.215160","type":"journal-article","created":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T20:27:24Z","timestamp":1313180844000},"page":"F116-F119","source":"Crossref","is-referenced-by-count":42,"title":["Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm 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