{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:32:34Z","timestamp":1759541554011},"reference-count":7,"publisher":"BMJ","issue":"206","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1964,8,1]]},"DOI":"10.1136\/adc.39.206.324","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T20:49:06Z","timestamp":1229978946000},"page":"324-333","source":"Crossref","is-referenced-by-count":21,"title":["Congenital Adrenal Hyperplasia"],"prefix":"10.1136","volume":"39","author":[{"given":"S.","family":"Raiti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. H.","family":"Newns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","article-title":"Peterson","author":"Peterson; Wyngaarden","year":"1956","unstructured":"Peterson and Wyngaarden (1956) Peterson (1957)"},{"key":"ref_2","article-title":"ketosteroids (17-oxysteroids) are substances","volume-title":"at position C-17 on the steroid nucleus. Though the estimation is nonspecific, it is helpful in controlling treatment. The value includes such derivatives as dehydroepiandrosterone, androsterone, and aetiocholanolone. In circumstances where the production of 17hydroxypregnane derivatives is very high, the 17-ketosteroids will be raised due to the conversion of about 5-100% of 17-hydroxypregnane derivatives. Values obtained in normal children are set out in Table 2 (Prout and Snaith","year":"1958","unstructured":"1 7-ketosteroids (17-oxysteroids) are substances that have a ketone group ( 0) at position C-17 on the steroid nucleus. Though the estimation is nonspecific, it is helpful in controlling treatment. The value includes such derivatives as dehydroepiandrosterone, androsterone, and aetiocholanolone. In circumstances where the production of 17hydroxypregnane derivatives is very high, the 17-ketosteroids will be raised due to the conversion of about 5-100% of 17-hydroxypregnane derivatives. Values obtained in normal children are set out in Table 2 (Prout and Snaith, 1958)."},{"key":"ref_3","article-title":"17-KETOSTEROID OUTPlT (PROUT AND SNAITH","author":"DAILY, N.O.R.M.A.L.","year":"1958","unstructured":"NORMAL DAILY 17-KETOSTEROID OUTPlT (PROUT AND SNAITH. 1958)"},{"key":"ref_4","article-title":"Pregnanetriol is an abnormal metabolite excreted in the urine of patients who have a block in 21-hydroxylation, and it can be measured","unstructured":"Pregnanetriol is an abnormal metabolite excreted in the urine of patients who have a block in 21-hydroxylation, and it can be measured."},{"key":"ref_5","article-title":"In patients with an 11hydroxylation defect, this abnormal metabolite is excreted in the urine and can be measured. It is found in the urine of patients with the hypertensive type of congenital adrenal hyperplasia (Bongiovanni and Eberlein, 1955). Administration of the drug, metyrapone (metopirone'), which blocks 1 1-hydroxylation, also causes excretion of this metabolite","author":"Tetrahydro-S.","unstructured":"'Tetrahydro-S. In patients with an 11hydroxylation defect, this abnormal metabolite is excreted in the urine and can be measured. It is found in the urine of patients with the hypertensive type of congenital adrenal hyperplasia (Bongiovanni and Eberlein, 1955). Administration of the drug, metyrapone (metopirone'), which blocks 1 1-hydroxylation, also causes excretion of this metabolite."},{"key":"ref_6","article-title":"l1-oxygenation index measures the ratio of substances without an oxygenation function at the C-1l position to those with such a function, i.e. cortisone and cortisol. The 1I -deoxygenated substances include 'compound S' and 1 7-x-hydroxyprogesterone and their abnormal metabolites","volume-title":"Normally the ratio of 1 1-deoxygenated to I 1-oxygenated substances is 1: 2 or less. If the ratio becomes reversed, i.e. 2: 1 or greater, it indicates that there are more precursor substances than there is cortisol and that there must be an accumulation of substances that have not been hydroxylated at the C-Il position. It does not indicate whether the block","author":"is at C-l I or C-21. The advantage is that the test can be performed on a random sample of urine (Barratt, and Clayton,","year":"1960","unstructured":"l1-oxygenation index measures the ratio of substances without an oxygenation function at the C-1l position to those with such a function, i.e. cortisone and cortisol. The 1I -deoxygenated substances include 'compound S' and 1 7-x-hydroxyprogesterone and their abnormal metabolites (Hill, 1960). Normally the ratio of 1 1-deoxygenated to I 1-oxygenated substances is 1: 2 or less. If the ratio becomes reversed, i.e. 2: 1 or greater, it indicates that there are more precursor substances than there is cortisol and that there must be an accumulation of substances that have not been hydroxylated at the C-Il position. It does not indicate whether the block is at C-l I or C-21. The advantage is that the test can be performed on a random sample of urine (Barratt, Edwards, Makin, and Clayton, 1964)."},{"issue":"1961","key":"ref_7","article-title":"Two-dimensional paper chromatography can be used to obtain a qualitative indication of the type of enzymatic block present","volume":"1960","year":"1962","unstructured":"Two-dimensional paper chromatography can be used to obtain a qualitative indication of the type of enzymatic block present (Edwards, 1960, 1961, 1962).","journal-title":"(Edwards"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.39.206.324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T08:45:32Z","timestamp":1601109932000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.39.206.324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,8,1]]},"references-count":7,"journal-issue":{"issue":"206","published-print":{"date-parts":[[1964,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.39.206.324","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1964,8,1]]}}}