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C. (1955). In Klinische Diagnostiek, pp. 276 and 440. Stenfert Kroese N.V., Leiden."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1542\/peds.14.3.245","article-title":"The concentration of different amino acids in the blood plasma in children suffering from rickets and scurvy","volume":"14","author":"Huisman, T.H.J.","year":"1954","unstructured":"Huisman, T. H. J. (1954). The concentration of different amino acids in the blood plasma in children suffering from rickets and scurvy. Pediatrics, 14, 245.","journal-title":"Pediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/adc.32.162.77","article-title":"Some investigations on the metaboLism of phenylalanine and tyrosine in children with vitamin C deficiency","volume":"32","author":"Huisman, T.H.J.; Jonxis, J.H.P.","year":"1957","unstructured":"Huisman, T. H. J., and Jonxis, J. H. P. (1957). Some investigations on the metaboLism of phenylalanine and tyrosine in children with vitamin C deficiency. Archives of Disease in Childhood, 32, 77.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1542\/peds.14.3.238","article-title":"Amino aciduria and ascorbic acid deficiency","volume":"14","author":"Jonxis, J.H.P.; Huisman, T.H.J.","year":"1954","unstructured":"Jonxis, J. H. P., and Huisman, T. H. J. (1954). Amino aciduria and ascorbic acid deficiency. Pediatrics, 14, 238.","journal-title":"Pediatrics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0021-9258(18)71178-2","article-title":"A modified ninhydrin reagent for the photometric determination of amino acids and related compounds","volume":"211","author":"Moore, S.; Stein, W.H.","year":"1954","unstructured":"Moore, S., and Stein, W. H. (1954). A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. Journal of Biological Chemistry, 211, 907.","journal-title":"Journal of Biological Chemistry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0021-9258(18)71179-4","article-title":"The free amino acids of human blood plasma","volume":"211","author":"Stein, W.H.; Moore, S.","year":"1954","unstructured":"Stein, W. H., and Moore, S. (1954). The free amino acids of human blood plasma. Journal of Biological Chemistry, 211, 915.","journal-title":"Journal of Biological Chemistry"},{"key":"ref_7","first-page":"113","article-title":"Scurvy, aminoacids and chromatography","volume":"84","author":"Turner, E.J.; Campbell, D.J.","year":"1961","unstructured":"Turner, E. J., and Campbell, D. J. (1961). Scurvy, aminoacids and chromatography. Canadian Medical Association Journal, 84, 113.","journal-title":"Canadian Medical Association Journal"},{"key":"ref_8","article-title":"It is clear from the results obtained on the present study that in vitamin C deficiency the tubular reabsorption of the aromatic amino acids, phenylalanine and tyrosine, is reduced, whereas in vitamin D deficiency it is not","volume-title":"As in our earlier investigations it was found that it takes many weeks, even with ampie vitamin C administration, before the tubular reabsorption of all amino acids reaches normal values","year":"1954","unstructured":"It is clear from the results obtained on the present study that in vitamin C deficiency the tubular reabsorption of the aromatic amino acids, phenylalanine and tyrosine, is reduced, whereas in vitamin D deficiency it is not (Huisman, 1954). As in our earlier investigations it was found that it takes many weeks, even with ampie vitamin C administration, before the tubular reabsorption of all amino acids reaches normal values."},{"key":"ref_9","article-title":"It has been postulated that a significant cause of brain damage in surviving premature babies is hypoxia secondary to recurrent apnoea","volume-title":"Present methods of managing such episodes consist of external stimulation, administration of oxygen, and assisted ventilation. However successful such measures are they do not prevent further apnoeic attacks which may be serious to the baby. It was this thought that suggested that aminophylline, by virtue of its direct action on the respiratory and vasomotor centres and on the myocardium, might be useful in the treatment and prevention of prolonged apnoeic attacks in the small baby","author":"Bacola","year":"1963","unstructured":"It has been postulated that a significant cause of brain damage in surviving premature babies is hypoxia secondary to recurrent apnoea (McDonald, 1963; Bacola et al., 1966; Daily, Klaus, and Meyer, 1969). Present methods of managing such episodes consist of external stimulation, administration of oxygen, and assisted ventilation. However successful such measures are they do not prevent further apnoeic attacks which may be serious to the baby. It was this thought that suggested that aminophylline, by virtue of its direct action on the respiratory and vasomotor centres and on the myocardium, might be useful in the treatment and prevention of prolonged apnoeic attacks in the small baby."},{"key":"ref_10","article-title":"Material and methods Ten preterm babies suffering from idiopathic respiratory distress syndrome (RDS) were studied. Criteria for diagnosis were those of Reynolds, Roberton, and Wigglesworth","volume-title":"An apnoeic attack was defined as a period of nonbreathing, usually lasting more than 30 seconds, during which cyanosis and slowing of the heart rate occurred. Hourly heart and respiratory rates were recorded. Routine care of babies consisted","year":"1968","unstructured":"Material and methods Ten preterm babies suffering from idiopathic respiratory distress syndrome (RDS) were studied. Criteria for diagnosis were those of Reynolds, Roberton, and Wigglesworth (1968). An apnoeic attack was defined as a period of nonbreathing, usually lasting more than 30 seconds, during which cyanosis and slowing of the heart rate occurred. Hourly heart and respiratory rates were recorded. 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