{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T04:15:14Z","timestamp":1684901714898},"reference-count":13,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1973,8,1]]},"DOI":"10.1136\/adc.48.8.650","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:05:14Z","timestamp":1229979914000},"page":"650-652","source":"Crossref","is-referenced-by-count":0,"title":["Red cell phospholipid determined in diagnosis of neurological disease."],"prefix":"10.1136","volume":"48","author":[{"given":"M I","family":"Griffiths","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0031-3955(16)32124-1","volume":"15","author":"Carpenter, G.G.; Auerbach, V.H.; DiGeorge, A.M.","year":"1968","unstructured":"Carpenter, G. G., Auerbach, V. H., and DiGeorge, A. M. (1968). Phenylalaninemia. Pediatric Clinics of North America, 15, 313.","journal-title":"Phenylalaninemia. Pediatric Clinics of North America"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1542\/peds.32.3.338","article-title":"A simple phenylalanine method for detecting phenylketonuria in large populations of newbom infants","volume":"32","author":"Guthrie, R.; Susi, A.","year":"1963","unstructured":"Guthrie, R., and Susi, A. (1963). A simple phenylalanine method for detecting phenylketonuria in large populations of newbom infants. Pediatrics, 32, 338.","journal-title":"Pediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0026-0495(67)90103-5","volume":"16","author":"Hsia, D.Y.Y.; O'Flynn, M.E.","year":"1967","unstructured":"Hsia, D. Y. Y., and O'Flynn, M. E. (1967). Hyperphenylalaninemia. Metabolism, 16, 99.","journal-title":"Hyperphenylalaninemia. Metabolism"},{"key":"ref_4","first-page":"5","article-title":"Phenylketonuria. In Amino Acid Metabolism and Genetic Variation","author":"Jervis, G.A.","year":"1967","unstructured":"Jervis, G. A. (1967). Phenylketonuria. In Amino Acid Metabolism and Genetic Variation, p. 5. Ed. by W. L. Nyhan. McGraw-Hill, New York."},{"key":"ref_5","first-page":"885","article-title":"Fluorimetric method for the determination of phenylalanine in serum","volume":"59","author":"McCaman, M.W.; Robins, E.","year":"1962","unstructured":"McCaman, M. W., and Robins, E. (1962). Fluorimetric method for the determination of phenylalanine in serum. Journal of Laboratory and Clinical Medicine, 59, 885.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1542\/peds.39.5.764","article-title":"Diagnosis and treatment: interpreting the positive screening test in the newborn infant","volume":"39","author":"Scriver, C.R.","year":"1967","unstructured":"Scriver, C. R. (1967). Diagnosis and treatment: interpreting the positive screening test in the newborn infant. Pediatrics, 39, 764.","journal-title":"Pediatrics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/clinchem\/10.12.1098","article-title":"Micromethods for measuring phenylalanine and tyrosine in serum","volume":"10","author":"Wong, P.W.K.; O'Flynn, M.E.; Inouye, T.","year":"1964","unstructured":"Wong, P. W. K., O'Flynn, M. E., and Inouye, T. (1964). Micromethods for measuring phenylalanine and tyrosine in serum. Clinical Chemistry, 10, 1098.","journal-title":"Clinical Chemistry"},{"key":"ref_8","article-title":"Following the report by Hooghwinkel","year":"1969","unstructured":"Following the report by Hooghwinkel, van Gelderen, and Staal (1969) that the sphingomyelin content of erythrocytes was found to be low in children with progressive brain disease, we decided to apply their method, modified in the light of more recent technical developments, to a number of patients suffering from severe mental and physical handicaps of uncertain cause. In all, 21 children were examined, both male and female, in the 3 to 14 years age group. In addition, 4 other groups of children with previously diagnosed brain disorders were studied (37 cases), along with a group of normal subjects (25 cases). The classification of the 37 cases broadly follows that of Hooghwinkel et al. (1969) except that we had no patients in his Group II (juvenile amaurotic idiocy), but we had an additional group (Ia) consisting of patients not expected to show abnormal erythrocyte sphingomyelin content.","journal-title":"of Hooghwinkel et al; that the sphingomyelin content of erythrocytes was found to be low in children with progressive brain disease, we decided to apply their method, modified in the light of more recent technical developments, to a number of patients suffering from severe mental and physical handicaps of uncertain cause. In all, 21 children were examined, both male and female, in the 3 to 14 years age group. In addition, 4 other groups of children with previously diagnosed brain disorders were studied (37 cases), along with a group of normal subjects (25 cases). The classification of the 37 cases broadly follows that"},{"key":"ref_9","article-title":"The biochemical analyses differed slightly from those of Hooghwinkel et al. and are described in full elsewhere","year":"1973","unstructured":"The biochemical analyses differed slightly from those of Hooghwinkel et al. and are described in full elsewhere (John and Forrest, 1973)."},{"key":"ref_10","article-title":"A~~~A cases of proven mucopolysaccharidosis (group III) had values below -2 SD of the mean, and the 3 cases of proven leucodystrophy (group IV) fell within the normal range. These results are similar to those reported by Hooghwinkel and his colleagues (1969), but the diagnosis in these groups was already established by other means and the determination of sphingomyelin in the red cells did not add evidence of diagnostic value","unstructured":"A~~~A cases of proven mucopolysaccharidosis (group III) had values below -2 SD of the mean, and the 3 cases of proven leucodystrophy (group IV) fell within the normal range. These results are similar to those reported by Hooghwinkel and his colleagues (1969), but the diagnosis in these groups was already established by other means and the determination of sphingomyelin in the red cells did not add evidence of diagnostic value."},{"key":"ref_11","article-title":"Sphingomyein of red blood cells in lipidosis and in dementia of unknown origin in children","volume":"44","author":"Hooghwinkel, G.J.M.; van Gelderen, H.H.; Staal, A.","year":"1969","unstructured":"Hooghwinkel, G. J. M., van Gelderen, H. H., and Staal, A. (1969). Sphingomyein of red blood cells in lipidosis and in dementia of unknown origin in children. Archives of Disease in Childhood, 44, 197.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/000456327301000104","article-title":"Determination of phospholipid fractions in red blood cells in retarded physically handicapped children","volume":"10","author":"John, F.M.; Forrest, G.C.","year":"1973","unstructured":"John, F. M., and Forrest, G. C. (1973). Determination of phospholipid fractions in red blood cells in retarded physically handicapped children. Annak of Clincal Biochenistry, 10, 23.","journal-title":"Annak of Clincal Biochenistry"},{"key":"ref_13","article-title":"The following articles will appear in future issues of this journal: Annotation: Beclomethasone in childhood asthma","unstructured":"The following articles will appear in future issues of this journal: Annotation: Beclomethasone in childhood asthma. R. S. Jones."}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.48.8.650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T03:38:15Z","timestamp":1684813095000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.48.8.650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,8,1]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1973,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.48.8.650","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,8,1]]}}}