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M.","family":"Gwynn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"402","article-title":"Side effects were experienced by most of our patients while they were taking 24 g EACA","volume":"1","author":"daily, Biggs; R., Macfarlane; G., R.; Pilling, J.","year":"1947","unstructured":"Side effects were experienced by most of our patients while they were taking 24 g EACA daily, Biggs, R., Macfarlane, R. G., and Pilling, J. (1947). Observations in fibrinolysis: experimental activity produced by exercise or adrenaline. Lancet, 1, 402 and in 3 of the 4 children taking 12 g EACA daily. They all complained of dizziness, particularly in the early morning, frequently had nausea, and occasionally diarrhoea; these side effects have been well documented in the past (Nilsson, Andersson, Champion, R. H., and Lachmann, P. J. (1969). Hereditary angiooedema treated with Epsilon-aminocaproic acid. British Journal of Dermatology, 81, 763.","edition":"past","journal-title":"Lancet; Observations in fibrinolysis: experimental activity produced by exercise or adrenaline"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1152\/jappl.1968.25.4.416","article-title":"C'1 activation in hereditary angioneurotic edema plasma: role of urokinase and inhibitors","volume":"25","author":"Donaldson, V.H.","year":"1968","unstructured":"Donaldson, V. H. (1968a). C'1 activation in hereditary angioneurotic edema plasma: role of urokinase and inhibitors. Journal of Applied Physiology, 25, 416.","journal-title":"Journal of Applied Physiology"},{"key":"ref_3","article-title":"Hereditary angioand Bjorkmann","author":"Donaldson, V.H.; Rosen, F.S.","year":"1966","unstructured":"Donaldson, V. H., and Rosen, F. S. (1966). Hereditary angioand Bjorkmann, 1966). Patient II.4 experienced menorrhagia lasting for 8 days after stopping EACA."},{"key":"ref_4","author":"Frank, M.M.","year":"1972","unstructured":"Frank, M. M., Sergent, J. S., Kane, M. A., and Alling, D. W. (1972)."},{"issue":"15","key":"ref_5","first-page":"808","article-title":"Epsilon aminocaproic acid therapy of hereditary angioneurotic All patients experienced muscle aches, which appeared after 5 to 6 days therapy and were particularly painful in the older children and adults, but less severe in the younger patients. The pain disappeared within hours of lowering the dose of edema","volume":"286","unstructured":"Epsilon aminocaproic acid therapy of hereditary angioneurotic All patients experienced muscle aches, which appeared after 5 to 6 days therapy and were particularly painful in the older children and adults, but less severe in the younger patients. The pain disappeared within hours of lowering the dose of edema. New England Journal of Medicine, 286, 15, 808.","journal-title":"New England Journal of Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2222.1971.tb03021.x","article-title":"Hereditary angio-oedema: a review with particular reference to pathogenesis and treatment","volume":"1","author":"Hadjiyannaki, K.; Lachmann, P.J.","year":"1971","unstructured":"Hadjiyannaki, K., and Lachmann, P. J. (1971). Hereditary angio-oedema: a review with particular reference to pathogenesis and treatment. Clinical Allergy, 1, 221.","journal-title":"Clinical Allergy"},{"key":"ref_7","article-title":"A polypeptide derived from the second component of human complement (C'2) which increases vascular permeability","author":"Klemperer, M.R.; Rosen, F.S.; Donaldson, V.H.","year":"1969","unstructured":"Klemperer, M. R., Rosen, F. S., and Donaldson, V. H. (1969). A polypeptide derived from the second component of human complement (C'2) which increases vascular permeability."},{"key":"ref_8","article-title":"This side effect has previously been recognized by Frank","volume":"48","author":"E.A.C.A.","year":"1972","unstructured":"EACA. This side effect has previously been recognized by Frank et al. (1972) who were able to (Abst. 142.) Journal of Clinical Investigation, 48, 44a. Landerman, N. S. (1962). Hereditary angionesrotic edema. I.","journal-title":"et al; who were able to (Abst. 142"},{"key":"ref_9","article-title":"Case reports and review of the literature","volume":"33","unstructured":"Case reports and review of the literature. Journal of Allergy, 33, show raised levels of creatinine phosphokinase during the attacks. This was not shown in the present trial because an attack was never witnessed. (The patients lived approximately 40 miles from the hospital and attended at 2-week intervals during the","journal-title":"Journal of Allergy; show raised levels of creatinine phosphokinase during the attacks. This was not shown in the present trial because an attack was never witnessed. (The patients lived approximately 40 miles from the hospital and attended at 2-week intervals during the"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0140-6736(46)91840-5","article-title":"Observations on fibrinolysis: spontaneous activity associated with surgical operations, trauma, etc","volume":"2","author":"Macfarlane, R.G.; Biggs, R.","year":"1946","unstructured":"Macfarlane, R. G., and Biggs, R. (1946). Observations on fibrinolysis: spontaneous activity associated with surgical operations, trauma, etc. Lancet, 2, 862.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/oxfordjournals.bmb.a070338","article-title":"Epsilon-aminocaproic acid and other inhibitors of fibrinolysis","volume":"20","author":"McNicol, G.P.; Douglas, A.S.","year":"1964","unstructured":"McNicol, G. P., and Douglas, A. S. (1964). Epsilon-aminocaproic acid and other inhibitors of fibrinolysis. British Medical Bulletin, 20, 233.","journal-title":"British Medical Bulletin"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","article-title":"Immunochemical quantitation of antigens by single radial immunodiffusion","volume":"2","author":"Mancini, G.; Carbonara, A.O.; Heremans, J.F.","year":"1965","unstructured":"Mancini, G., Carbonara, A. O., and Heremans, J. F. (1965). Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry, 2, 235.","journal-title":"Immunochemistry"},{"key":"ref_13","first-page":"835","article-title":"New England journal of Medicine (1972). Editorial. Therapy of 'the neurotic edema'","volume":"286","unstructured":"New England journal of Medicine (1972). Editorial. Therapy of 'the neurotic edema', 286, 835."},{"key":"ref_14","article-title":"Epsilon aminocaproic acid as a therapeutic agent. Based on 5 rapidly as the symptoms disappeared. It was therefore decided by the patients themyears clinical experience","volume":"448","author":"Nilsson, I.M.; Andersson, L.; Bjorkmann, S.E.","year":"1966","unstructured":"Nilsson, I. M., Andersson, L., and Bjorkmann, S. E. (1966). Epsilon aminocaproic acid as a therapeutic agent. Based on 5 rapidly as the symptoms disappeared. It was therefore decided by the patients themyears clinical experience. Acta Medica Scandinavica, 448, (Suppl.)","journal-title":"Acta Medica Scandinavica"},{"key":"ref_15","article-title":"Hereditary angioneurotic edema. American selves that continuous therapy was the most effective, but that the dose required varied with each patient. It appeared that those who were immunochemically and clinically more severely affected required higher doses. However, none of the older","volume":"362","author":"Osler, W.","year":"1888","unstructured":"Osler, W. (1888). Hereditary angioneurotic edema. American selves that continuous therapy was the most effective, but that the dose required varied with each patient. It appeared that those who were immunochemically and clinically more severely affected required higher doses. However, none of the older Journal of the Medical Sciences, 95, 362. Pickering, R. J., Kelly, J. R., Good, R. A., and Gewurz, H. (1969).","journal-title":"Journal of the Medical Sciences, 95"},{"key":"ref_16","year":"1953","unstructured":"Pillemer, L., Ratnoff, 0. D., Blum, L., and Lepow, I. H. (1953)."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1084\/jem.97.4.573","article-title":"The inactivation of complement and its components by plasmin","volume":"97","unstructured":"The inactivation of complement and its components by plasmin. Journal of Experimental Medicine, 97, 573.","journal-title":"Journal of Experimental Medicine"},{"key":"ref_18","first-page":"452","article-title":"Tranexamic patients needed more than 12 g\/day EACA and none of the children required more than 6 g\/day for acid therapy in hereditary angioneurotic edema","volume":"287","author":"Sheffer, A.L.; Austen, F.K.; Rosen, F.S.","year":"1972","unstructured":"Sheffer, A. L., Austen, F. K., and Rosen, F. S. (1972). Tranexamic patients needed more than 12 g\/day EACA and none of the children required more than 6 g\/day for acid therapy in hereditary angioneurotic edema. 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