{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:35:41Z","timestamp":1784864141938,"version":"3.55.0"},"reference-count":28,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1975,6,1]]},"DOI":"10.1136\/adc.50.6.458","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:14:24Z","timestamp":1229980464000},"page":"458-462","source":"Crossref","is-referenced-by-count":36,"title":["Acute myelofibrosis in children with Down's syndrome."],"prefix":"10.1136","volume":"50","author":[{"given":"D I","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"499","article-title":"Splenomegalie myeloide familiale. Nouvelle Revue Fran; aise","volume":"7","author":"Bernard, J.; Seligmann, M.; Loirat, Ch; Chassigneux, J.; Basch, A.; Gueudet, A.","year":"1967","unstructured":"Bernard, J., Seligmann, M., Loirat, Ch., Chassigneux, J., Basch, A., and Gueudet, A. (1967). Splenomegalie myeloide familiale. Nouvelle Revue Fran;aise d'Hematologie, 7, 499.","journal-title":"d'Hematologie"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2141.1973.tb01744.x","article-title":"Fine structure and peroxidase activity of circulating micromegakaryoblasts and platelets in a case of acute myelofibrosis","volume":"25","author":"Breton Gorius, J.; Daniel, M.T.; Flandrin, G.; Kinet Denoel, G.","year":"1973","unstructured":"Breton Gorius, J., Daniel, M. T., Flandrin, G., and Kinet Denoel, G. (1973). Fine structure and peroxidase activity of circulating micromegakaryoblasts and platelets in a case of acute myelofibrosis. British Journal of Haematology, 25, 331.","journal-title":"British Journal of Haematology"},{"key":"ref_3","first-page":"935","article-title":"Increased number of stem cells in blood of patients with myelofibrosis","volume":"40","author":"Chervenick, P.A.","year":"1972","unstructured":"Chervenick, P. A. (1972). Increased number of stem cells in blood of patients with myelofibrosis. (Abst.) Blood, 40, 935.","journal-title":"(Abst.) Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1182\/blood.V6.4.372.372","article-title":"Some speculations on the myeloproliferative syndrome","volume":"6","author":"Dameshek, W.","year":"1951","unstructured":"Dameshek, W. (1951). Some speculations on the myeloproliferative syndrome. Blood, 6, 372.","journal-title":"Blood"},{"key":"ref_5","first-page":"655","article-title":"Osteomyelosklerose bei Vater und Tochter","volume":"66","author":"Decastello, A.","year":"1954","unstructured":"Decastello, A. (1954). Osteomyelosklerose bei Vater und Tochter. Wiener Klinische Wochenschrift, 66, 655.","journal-title":"Wiener Klinische Wochenschrift"},{"key":"ref_6","first-page":"226","article-title":"A case of megakaryocytic myelosis in a child","volume":"7","author":"Fujinami, T.; Sugiyama, T.; Tankawa, H.; Uesugi, Y.","year":"1961","unstructured":"Fujinami, T., Sugiyama, T., Tankawa, H., and Uesugi, Y. (1961). A case of megakaryocytic myelosis in a child. Annales Paediatrica japonica, 7, 226.","journal-title":"Annales Paediatrica japonica"},{"key":"ref_7","first-page":"95","article-title":"Hyperblastic response to","volume":"1","author":"Hayakawa, H.; Matsui, I.; Higurashi, M.; Kobayashi, N.","year":"1968","unstructured":"Hayakawa, H., Matsui, I., Higurashi, M., and Kobayashi, N. (1968). Hyperblastic response to dilute P.H.A. in Down's syndrome. Lancet, 1, 95.","edition":"dilute","journal-title":"Lancet; in Down's syndrome"},{"issue":"7","key":"ref_8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF02946511","article-title":"Myelofibrosis simulating acute leukaemia in a female infant with Down's syndrome","volume":"1","author":"Hillman, F.; Forrester, R.M.","year":"1968","unstructured":"Hillman, F., and Forrester, R. M. (1968). Myelofibrosis simulating acute leukaemia in a female infant with Down's syndrome. Irish J'ournal of Medical Science, 1, 7th series, 167.","journal-title":"Irish J'ournal of Medical Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/ajcp\/55.5.573","article-title":"Myelofibrosis with C monosomy of marrow elements in a child","volume":"55","author":"Holden, J.D.; Garcia, F.U.; Samuels, M.; Dupin, C.; Stallworth, B.; Anderson, E.","year":"1971","unstructured":"Holden, J. D., Garcia, F. U., Samuels, M., Dupin, C., Stallworth, B., and Anderson, E. (1971). Myelofibrosis with C monosomy of marrow elements in a child. American Journal of Clinical Pathology, 55, 573.","journal-title":"American Journal of Clinical Pathology"},{"issue":"6","key":"ref_10","article-title":"Idiopathic myelofibrosis developing in early childhood","volume":"15","author":"Klimova, N.F.; Indosova, E.N.; Zacharova, A.V.","year":"1970","unstructured":"Klimova, N. F., Indosova, E. N., and Zacharova, A. V. (1970). Idiopathic myelofibrosis developing in early childhood. Problemi Gematologi and Perilevanyi Krovi, 15, No. 6, 52.","journal-title":"Problemi Gematologi and Perilevanyi Krovi"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1651-2227.1967.tb15401.x","article-title":"Myelofibrosis and myeloid leukaemia","volume":"56","author":"Krasilnikoff, P.A.","year":"1967","unstructured":"Krasilnikoff, P. A. (1967). Myelofibrosis and myeloid leukaemia. Acta Paediatrica Scandinavica, 56, 424.","journal-title":"Acta Paediatrica Scandinavica"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archpedi.1957.04030040075012","article-title":"Simultaneous occurrence of mongolism and leukemia: report of a nationwide survey","volume":"94","author":"Krivit, W.; Good, R.A.","year":"1957","unstructured":"Krivit, W., and Good, R. A. (1957). Simultaneous occurrence of mongolism and leukemia: report of a nationwide survey. American J7ournal of Diseases of Children, 94, 289.","journal-title":"American J7ournal of Diseases of Children"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1182\/blood.V23.4.526.526","article-title":"Reticulin fibrosis and bone marrow infarction in acute leukemia. Implications for prognosis","volume":"23","author":"Kundel, D.W.; Brecher, G.; Bodey, G.P.; Brittin, G.M.","year":"1964","unstructured":"Kundel, D. W., Brecher, G., Bodey, G. P., and Brittin, G. M. (1964). Reticulin fibrosis and bone marrow infarction in acute leukemia. Implications for prognosis. Blood, 23, 526.","journal-title":"Blood"},{"key":"ref_14","first-page":"472","article-title":"Malignant myelosclerosis","volume":"2","author":"Lewis, S.M.; Szur, L.","year":"1963","unstructured":"Lewis, S. M., and Szur, L. (1963). Malignant myelosclerosis. British Medical Journal, 2, 472.","journal-title":"British Medical Journal"},{"key":"ref_15","first-page":"56","article-title":"Verlauf einer Osteomyelofibrose seit dem","volume":"119","author":"Maas, B.; Ruhrmann, G.","year":"1971","unstructured":"Maas, B., and Ruhrmann, G. (1971). Verlauf einer Osteomyelofibrose seit dem Sauglinsalter. Monatsschrift fur Kinderheilkunde, 119, 56."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1749-6632.1970.tb39363.x","article-title":"Abnormal lvmphocyte function in trisomy 21","volume":"171","author":"Mellman, W.J.; Younkin, L.H.; Baker, D.","year":"1970","unstructured":"Mellman, W. J., Younkin, L. H., and Baker, D. (1970). Abnormal lvmphocyte function in trisomy 21. Annals of the New York Academy of Sciences, 171, 537.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1542\/peds.40.5.847","article-title":"Thrombocythemia in the myeloproliferative disorder of Down's syndrome","volume":"40","author":"Miller, J.McC; Sherrill, J.G.; Hathaway, W.E.","year":"1967","unstructured":"Miller, J. McC., Sherrill, J. G., and Hathaway, W. E. (1967). Thrombocythemia in the myeloproliferative disorder of Down's syndrome. Pediatrics, 40, 847.","journal-title":"Pediatrics"},{"key":"ref_18","first-page":"81","article-title":"An autopsy case of primary osteomyelosclerosis in a 6-year old girl","volume":"19","author":"Nagai, K.; Sugiyama, Y.; Isono, Y.; Yoshida, K.","year":"1969","unstructured":"Nagai, K., Sugiyama, Y., Isono, Y., and Yoshida, K. (1969). An autopsy case of primary osteomyelosclerosis in a 6-year old girl. Acta Pathologica Japonica, 19, 81.","journal-title":"Acta Pathologica Japonica"},{"key":"ref_19","first-page":"217","article-title":"Familial myelofibrosis","volume":"3","author":"Patakfalvi, A.; Csete, B.; Horvath, T.","year":"1969","unstructured":"Patakfalvi, A., Csete, B., and Horvath, T. (1969). Familial myelofibrosis. Haematologia, 3, 217.","journal-title":"Haematologia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0022-3476(68)80097-6","article-title":"Disseminated intravascular coagulation in a newborn with Down's syndrome","volume":"73","author":"Fochedly, C.; Ente, G.","year":"1968","unstructured":"Fochedly, C., and Ente, G. (1968). Disseminated intravascular coagulation in a newborn with Down's syndrome. Journal of Pediatrics, 73, 298.","journal-title":"Journal of Pediatrics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0022-3476(58)80061-X","article-title":"The myeloproliferative syndrome in children","volume":"52","author":"Rosenberg, H.S.; Taylor, F.M.","year":"1958","unstructured":"Rosenberg, H. S., and Taylor, F. M. (1958). The myeloproliferative syndrome in children. Journal of Pediatrics, 52, 407.","journal-title":"Journal of Pediatrics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3476(63)80296-6","article-title":"Ineffective regulation of granulopoiesis masquerading as congenital leukemia in a mongoloid child","volume":"63","author":"Ross, J.D.; Maloney, W.C.; Desforges, J.F.","year":"1963","unstructured":"Ross, J. D., Maloney, W. C., and Desforges, J. F. (1963). Ineffective regulation of granulopoiesis masquerading as congenital leukemia in a mongoloid child. Journal of Pediatrics, 63, 1.","journal-title":"Journal of Pediatrics"},{"key":"ref_23","first-page":"89","article-title":"Myelotomy in obscure infantile anaemias, performed in two cases of infantile myelofibrosis","volume":"15","author":"Ruhrmann, G.","year":"1967","unstructured":"Ruhrmann, G. (1967). Myelotomy in obscure infantile anaemias, performed in two cases of infantile myelofibrosis. Blut, 15, 89.","journal-title":"Blut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/222596b0","article-title":"Hypersensitivity of lymphocytes in Down's syndrome shown by mixed lymphocyte culture experiments","volume":"222","author":"Sasaki, M.; Obara, Y.","year":"1969","unstructured":"Sasaki, M., and Obara, Y. (1969). Hypersensitivity of lymphocytes in Down's syndrome shown by mixed lymphocyte culture experiments. Nature, 222, 596.","journal-title":"Nature"},{"key":"ref_25","first-page":"1080","article-title":"Myelofibrosis in pediatric age group","volume":"69","author":"Tobin, M.S.; Tan, C.; Argano, S.A.P.","year":"1969","unstructured":"Tobin, M. S., Tan, C., and Argano, S. A. P. (1969). Myelofibrosis in pediatric age group. New York State Journal of Medicine, 69, 1080.","journal-title":"New York State Journal of Medicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0022-3476(70)80335-3","article-title":"Congenital marrow dysfunction in Down's syndrome","volume":"77","author":"Weinberger, M.M.; Oleinick, A.","year":"1970","unstructured":"Weinberger, M. M., and Oleinick, A. (1970). Congenital marrow dysfunction in Down's syndrome. Journal of Pediatrics, 77, 273.","journal-title":"Journal of Pediatrics"},{"key":"ref_27","article-title":"Clinical Hematology","author":"Wintrobe, M.M.","year":"1967","unstructured":"Wintrobe, M. M. (1967). Clinical Hematology, 6th ed. Lea and Febiger, Fhildelphia.","edition":"6th ed."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1749-6632.1970.tb39365.x","article-title":"A critical examination of some reported biochemical abnormalities in mongolism","volume":"171","author":"Woodford, F.P.; Bearn, A.G.","year":"1970","unstructured":"Woodford, F. P., and Bearn, A. G. (1970). A critical examination of some reported biochemical abnormalities in mongolism. Annals of the New York Academy of Sciences, 171, 551.","journal-title":"Annals of the New York Academy of Sciences"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.50.6.458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T03:40:32Z","timestamp":1684813232000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.50.6.458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6,1]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1975,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.50.6.458","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,6,1]]}}}