{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:34:51Z","timestamp":1791977691827,"version":"4.4.0"},"reference-count":8,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1975,8,1]]},"DOI":"10.1136\/adc.50.8.658","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:14:24Z","timestamp":1229980464000},"page":"658-661","source":"Crossref","is-referenced-by-count":27,"title":["Lupus-scleroderma syndrome induced by ethosuximide."],"prefix":"10.1136","volume":"50","author":[{"given":"P C","family":"Teoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H L","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"922","article-title":"Pseudohypoparathyroidism-an example of Seabright-Bantam syndrome","volume":"30","author":"Albright, F.; Burnett, C.H.; Smith, P.H.; Parson, W.","year":"1942","unstructured":"Albright, F., Burnett, C. H., Smith, P. H., and Parson, W. (1942). Pseudohypoparathyroidism-an example of Seabright-Bantam syndrome. Endocrinology, 30, 922.","journal-title":"Endocrinology"},{"key":"ref_2","article-title":"LE cells and antinuclear factor were again Laboratory investigations showed haemoglobin 6 g\/dl, present. As the cutaneous lesions clinically suggested white cell count 2000\/mm', platelet count 10 000\/mm,' scleroderma, a skin biopsy over the right thigh was done","author":"mm\/h","unstructured":"mm\/h. LE cells and antinuclear factor were again Laboratory investigations showed haemoglobin 6 g\/dl, present. As the cutaneous lesions clinically suggested white cell count 2000\/mm', platelet count 10 000\/mm,' scleroderma, a skin biopsy over the right thigh was done."},{"issue":"0","key":"ref_3","article-title":"Further improvement took place over the next 3 months, the skin became normal and the anaemia completely corrected. Hb was 13 g\/dl, white cell count 5000\/mm'","volume":"100","author":"This is supported","year":"1955","unstructured":"Further improvement took place over the next 3 months, the skin became normal and the anaemia completely corrected. Hb was 13 g\/dl, white cell count 5000\/mm', and platelet count 100 000\/mm3. Remission of the drug-induced SLE was further confirmed by a normal ESR of 12 mm\/h, disappearance of LE cells, and negative Coombs's test and VDRL. During this period phenobarbitone did not control her epilepsy. She had frequent grand mal seizures interspersed with fainting Though it is well known that some anticonvulsants can cause the lupus syndrome, it is important to be aware that epilepsy may be the initial manifestation of SLE (Haserick, 1955). However, we believe that our patient had idiopathic epilepsy since childhood and that SLE was induced by the anticonvulsant 14 years later. This is supported by the fact that all the features of SLE subsided attacks of brief duration. Diphenylhydantoin 100 mg soon after withdrawal of the anticonvulsant drugs.","journal-title":"and platelet count; Remission of the drug-induced SLE was further confirmed by a normal ESR of 12 mm\/h, disappearance of LE cells, and negative Coombs's test and VDRL. During this period phenobarbitone did not control her epilepsy. She had frequent grand mal seizures interspersed with fainting Though it is well known that some anticonvulsants can cause the lupus syndrome, it is important to be aware that epilepsy may be the initial manifestation of SLE"},{"key":"ref_4","article-title":"three times a day was therefore given in addition to All these features of SLE were present again 6 phenobrarbitone. No relapse of SLE was detected over the next 6 weeks. Hb, white cell count, platelet count, and ESR tests done at weekly intervals were normal, and the LE cells and Coombs's test remained negative. The addition of diphenylhydantoin reduced the frequency of grand mal attacks but the minor seizures continued. It was decided at that stage to put months later when ethosuximide was readministered. Though diphenylhydantoin and troxidone have long been known to induce SLE, the first case of ethosuximide-induced SLE was reported by","year":"1968","unstructured":"three times a day was therefore given in addition to All these features of SLE were present again 6 phenobrarbitone. No relapse of SLE was detected over the next 6 weeks. Hb, white cell count, platelet count, and ESR tests done at weekly intervals were normal, and the LE cells and Coombs's test remained negative. The addition of diphenylhydantoin reduced the frequency of grand mal attacks but the minor seizures continued. It was decided at that stage to put months later when ethosuximide was readministered. Though diphenylhydantoin and troxidone have long been known to induce SLE, the first case of ethosuximide-induced SLE was reported by Livingston et al. (1968). There is no doubt that SLE in this patient was induced by ethoe.;.:..:.","journal-title":"Livingston et al; There is no doubt that SLE in this patient was induced by ethoe"},{"key":"ref_5","first-page":"664","article-title":"Drug-induced lupus syndromes. Mayo Clinic","volume":"44","author":"Alarc6n-Segovia, D.","year":"1969","unstructured":"Alarc6n-Segovia, D. (1969). Drug-induced lupus syndromes. Mayo Clinic Proceedings, 44, 664.","journal-title":"Proceedings"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0021-9681(55)90040-0","article-title":"Modern concepts of systemic lupus erythematosus: a review of 126 cases","volume":"1","author":"Haserick, J.R.","year":"1955","unstructured":"Haserick, J. R. (1955). Modern concepts of systemic lupus erythematosus: a review of 126 cases. Journal of Chronic Diseases, 1, 317.","journal-title":"Journal of Chronic Diseases"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/jama.1968.03140210087025","article-title":"Systemic lupus erythematosus. Occurrence in association with ethosuximide therapy","volume":"204","author":"Livingston, S.; Rodriguez, H.; Greene, C.A.; Pauli, L.L.","year":"1968","unstructured":"Livingston, S., Rodriguez, H., Greene, C. A., and Pauli, L. L. (1968). Systemic lupus erythematosus. Occurrence in association with ethosuximide therapy. Journal of the American Medical Association, 204, 731.","journal-title":"Journal of the American Medical Association"},{"key":"ref_8","first-page":"83","article-title":"Classification and pathogenesis of scleroderma. Mayo Clinic","volume":"46","author":"Winkelmann, R.K.","year":"1971","unstructured":"Winkelmann, R. K. (1971). Classification and pathogenesis of scleroderma. Mayo Clinic Proceedings, 46, 83.","journal-title":"Proceedings"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.50.8.658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:05:14Z","timestamp":1601111114000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.50.8.658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,8,1]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1975,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.50.8.658","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,8,1]]}}}