{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T23:42:36Z","timestamp":1649202156422},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1976,5,1]]},"DOI":"10.1136\/adc.51.5.400","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:14:24Z","timestamp":1229980464000},"page":"400-401","source":"Crossref","is-referenced-by-count":1,"title":["Letter: Usefulness of the xylose test for coeliac disease."],"prefix":"10.1136","volume":"51","author":[{"given":"L","family":"Ose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Fluge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"issue":"35","key":"ref_1","first-page":"71","article-title":"Avoidance of shunt dependency in hydrocephalus","volume":"17","author":"Epstein, F.J.; Hochwald, G.M.; Wald, A.; Ransohoff, J.","year":"1975","unstructured":"Epstein, F. J., Hochwald, G. M., Wald, A., and Ransohoff, J. (1975). Avoidance of shunt dependency in hydrocephalus. Developmental Medicine and Child Neurology, 17, Suppl. 35, 71.","journal-title":"Developmental Medicine and Child Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/adc.49.2.112","article-title":"Primary ventriculo-peritoneal shunts in treatment of hydrocephalus associated with myelomeningocele","volume":"49","author":"Stark, G.D.; Drummond, M.B.; Poneprasert, S.; Robarts, F.H.","year":"1974","unstructured":"Stark, G. D., Drummond, M. B., Poneprasert, S., and Robarts, F. H. (1974). Primary ventriculo-peritoneal shunts in treatment of hydrocephalus associated with myelomeningocele. Archives of Disease in Childhood, 49, 112.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_3","article-title":"We have read with interest the discussion in the Archives (1975, 50, 748) by Rolles et","author":"Sir","year":"1975","unstructured":"Sir, We have read with interest the discussion in the Archives (1975, 50, 748) by Rolles et al., and Lamabadusuriya et al. following the communications of Lamabadusuriya, Packer, and Harries (1975) and Rolles, Anderson, and McNeish (1975).","journal-title":"al., and Lamabadusuriya et al. following the communications of Lamabadusuriya, Packer, and Harries; and Rolles"},{"issue":"2","key":"ref_4","article-title":"During a li-year period in 1972-73 we performed 93 xylose tolerance tests on 75 children as a screening procedure (Ose and Fluge, 1974). 57 duodenal biopsies were also performed on 48 patients. Before biopsy, D-xylose (O0 5 g\/kg) was given as a 5% solution, and capillary specimens were collected before","volume-title":"hours after. Whenever possible a 5-hour urine collection was completed. Urine and blood xylose were measured using o-toluidine","volume":"1","year":"1973","unstructured":"During a li-year period in 1972-73 we performed 93 xylose tolerance tests on 75 children as a screening procedure (Ose and Fluge, 1974). 57 duodenal biopsies were also performed on 48 patients. Before biopsy, D-xylose (O0 5 g\/kg) was given as a 5% solution, and capillary specimens were collected before, and at i, 1, and 2 hours after. Whenever possible a 5-hour urine collection was completed. Urine and blood xylose were measured using o-toluidine (Ose, 1973)."},{"key":"ref_5","article-title":"The xylose tolerance tests were grouped according to clinical symptoms and final diagnosis, but only untreated coeliac patients showed significantly reduced absorption. The test was of no use in evaluation of 16 patients with silent relapse on gluten-containing diet, as in older children with untreated coeliac disease","volume-title":"Though all those patients had mucosal changes, the xylose absorption did not differ from the controls","year":"1972","unstructured":"The xylose tolerance tests were grouped according to clinical symptoms and final diagnosis, but only untreated coeliac patients showed significantly reduced absorption. The test was of no use in evaluation of 16 patients with silent relapse on gluten-containing diet, as in older children with untreated coeliac disease (Visakorpi, 1972). Though all those patients had mucosal changes, the xylose absorption did not differ from the controls."},{"key":"ref_6","article-title":"A 5-hour urine xylose test could only be completed in 59 of 79 patients as part of the diagnostic work up. The difficulties in obtaining accurately timed urine collections resulted in urine only from 1 of 4 untreated coeliac children during the years 1972-73. We agree that the urinary xylose test should be abandoned as a screening test in the paediatric population, but find that the blood xylose tolerance test is of value if one is aware of its limitations","unstructured":"A 5-hour urine xylose test could only be completed in 59 of 79 patients as part of the diagnostic work up. The difficulties in obtaining accurately timed urine collections resulted in urine only from 1 of 4 untreated coeliac children during the years 1972-73. We agree that the urinary xylose test should be abandoned as a screening test in the paediatric population, but find that the blood xylose tolerance test is of value if one is aware of its limitations."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/adc.50.1.34","article-title":"Limitations of xylose tolerance test as a screening procedure in childhood coeliac disease","volume":"50","author":"Lamabadusuriya, S.P.; Packer, S.; Harries, J.T.","year":"1975","unstructured":"Lamabadusuriya, S. P., Packer, S., and Harries, J. T. (1975). Limitations of xylose tolerance test as a screening procedure in childhood coeliac disease. Archives of Disease in Childhood, 50, 34.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_8","first-page":"2103","article-title":"D-xylose tolerance in malabsorption: method of determining D-xylose in serum and urine. Tidsskrift for Den Norske","volume":"93","author":"Ose, L.","year":"1973","unstructured":"Ose, L. (1973). D-xylose tolerance in malabsorption: method of determining D-xylose in serum and urine. Tidsskrift for Den Norske Legeforening, 93, 2103.","journal-title":"Legeforening"},{"key":"ref_9","first-page":"1192","article-title":"The D-xylose tolerance test as screening test for malabsorption disorders in infancy and and childhood. Tidsskrift for Den Norske","volume":"94","author":"Ose, L.; Fluge, G.","year":"1974","unstructured":"Ose, L., and Fluge, G. (1974). The D-xylose tolerance test as screening test for malabsorption disorders in infancy and and childhood. Tidsskrift for Den Norske Legeforening, 94, 1192.","journal-title":"Legeforening"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/adc.50.4.259","article-title":"Confirming persistence of gluten intolerance in children diagnosed as having coeliac disease in infancy: usefulness of one-hour blood xylose test","volume":"50","author":"Rolles, C.J.; Anderson, C.M.; McNeish, A.S.","year":"1975","unstructured":"Rolles, C. J., Anderson, C. M., and McNeish, A. S. (1975). Confirming persistence of gluten intolerance in children diagnosed as having coeliac disease in infancy: usefulness of one-hour blood xylose test. Archives of Disease in Childhood, 50, 259.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_11","first-page":"27","article-title":"Die Spantmanifestationen und Spatdiagnostik bei Coeliaki","volume":"7","author":"Visakorpi, J.K.","year":"1972","unstructured":"Visakorpi, J. K. (1972). Die Spantmanifestationen und Spatdiagnostik bei Coeliaki. Pediatri und Padologie, 7, 27.","journal-title":"Pediatri und Padologie"},{"key":"ref_12","article-title":"In the paper by Challacombe","author":"Sir","year":"1975","unstructured":"Sir, In the paper by Challacombe et al. (1975) concerning urinary 5-hydroxyindoleacetic acid (5-HIAA) in coeliac disease, it is stated that the urinary 5-HIAA:creatinine ratio may be useful as 'an aid in the diagnosis of coeliac disease'. The critical question is, Does the finding of a normal urinary 5-HIAA: creatinine ratio justify the omission of jejunal biopsy when the diagnosis of coeliac disease is being considered ? Since their own data indicate that more than half(10\/18) ofpatients with coeliac disease have values for this ratio within the normal range, the answer appears to be no. Though the reported findings are interesting in themselves, the authors' claim that the test has diagnostic value is difficult to justify. As with other 'screening' tests for coeliac disease which have been proposed in the past, the discriminating power of this ratio is unacceptably low. The only safe rule continues to be: when in doubt-biopsy.","journal-title":"et al; concerning urinary 5-hydroxyindoleacetic acid (5-HIAA) in coeliac disease, it is stated that the urinary 5-HIAA: creatinine ratio may be useful as 'an aid in the diagnosis of coeliac disease'. The critical question is, Does the finding of a normal urinary 5-HIAA: creatinine ratio justify the omission of jejunal biopsy when the diagnosis of coeliac disease is being considered ? Since their own data indicate that more than half(10\/18) ofpatients with coeliac disease have values for this ratio within the normal range, the answer appears to be no. Though the reported findings are interesting in themselves, the authors' claim that the test has diagnostic value is difficult to justify. As with other 'screening' tests for coeliac disease which have been proposed in the past, the discriminating power of this ratio is unacceptably low. The only safe rule continues to be: when in doubt-biopsy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/adc.50.10.779","article-title":"Urinary 5-hydroxyindoleacetic acid in 8-hour collections as an aid in diagnosis of coeliac disease","volume":"50","author":"Challacombe, D.N.; Goodall, M.; Gaze, H.; Brown, G.A.","year":"1975","unstructured":"Challacombe, D. N., Goodall, M., Gaze, H., and Brown, G. A. (1975). Urinary 5-hydroxyindoleacetic acid in 8-hour collections as an aid in diagnosis of coeliac disease. Archives of Disease in Childhood, 50, 779.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_14","series-title":"The finding of a normal urinary 5-HIAA creatinine ratio does not justify the omission of jejunal biopsy when the diagnosis of coeliac disease is under consideration. However, it remains a useful aid in deciding whether small intestinal biopsy should be performed. Overlap of the data mentioned by Dr. Haycock and shown in Fig. 2 was almost entirely due to an age-related change in the ratio. Fig. 1 shows that 'when coeliac disease results were compared with results from control children of similar age only one was exceeded by a control value","article-title":"Challacombe comments: The letter by Dr. Haycock poses two interesting questions which have both been answered in the text of our","author":"N, D.","year":"1975","unstructured":"Dr. D. N. Challacombe comments: The letter by Dr. Haycock poses two interesting questions which have both been answered in the text of our paper (Challacombe et al., 1975). The finding of a normal urinary 5-HIAA creatinine ratio does not justify the omission of jejunal biopsy when the diagnosis of coeliac disease is under consideration. However, it remains a useful aid in deciding whether small intestinal biopsy should be performed. Overlap of the data mentioned by Dr. Haycock and shown in Fig. 2 was almost entirely due to an age-related change in the ratio. Fig. 1 shows that 'when coeliac disease results were compared with results from control children of similar age only one was exceeded by a control value'."}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.51.5.400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:06:50Z","timestamp":1601111210000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.51.5.400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,5,1]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1976,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.51.5.400","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,5,1]]}}}