{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T13:52:57Z","timestamp":1648561977305},"reference-count":5,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[1978,11]]},"DOI":"10.1136\/adc.53.11.919","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:33:49Z","timestamp":1229981629000},"page":"919.1-919","source":"Crossref","is-referenced-by-count":0,"title":["Renin and aldosterone response in human newborns to acute change in blood volume."],"prefix":"10.1136","volume":"53","author":[{"given":"S","family":"Frangatos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Hadjigeorgiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Constantinides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Kalpoyiannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Nicolopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/adc.52.7.545","article-title":"Alterations in blood pressure during exchange transfusion","volume":"52","author":"Aranda, J.V.; Sweet, A.Y.","year":"1977","unstructured":"Aranda, J. V., and Sweet, A. Y. (1977). Alterations in blood pressure during exchange transfusion. Archives of Disease in Childhood, 52, 545-548.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1210\/jcem-29-10-1349","article-title":"Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects","volume":"29","author":"Haber, W.; Koerner, T.; Page, L.B.; Kliman, B.; Purnode, A.","year":"1969","unstructured":"Haber, W., Koerner, T., Page, L. B., Kliman, B., and Purnode, A. (1969). Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 29, 1349-1355.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"449","key":"ref_3","article-title":"In their interesting paper","volume":"53","author":"Sir","year":"1978","unstructured":"Sir, In their interesting paper (Archives, 1978, 53, 449), Packer et al. state that (after a 3-to 4-month period of gluten ingestion) 'the finding of a normal postchallenge biopsy excludes coeliac disease', but they also counsel that such children should be followed for up to 2 years after challenge, with the implication that a normal biopsy at this time definitely excludes coeliac disease.","journal-title":"(Archives; state that (after a 3-to 4-month period of gluten ingestion) 'the finding of a normal postchallenge biopsy excludes coeliac disease', but they also counsel that such children should be followed for up to 2 years after challenge, with the implication that a normal biopsy at this time definitely excludes coeliac disease"},{"key":"ref_4","article-title":"We have made a preliminary report of a similar study which is being published in greater detail","volume-title":"40 children were challenged with gluten after a mean of 5-8 years on gluten-free diets and so far 37 have been confirmed to have coeliac disease by the occurrence of mucosal relapse. In some children, the mucosal relapse was very much slower than in the patients of Packer et","author":"al. In","year":"1979","unstructured":"We have made a preliminary report of a similar study which is being published in greater detail (McNicholl et al., 1979). 40 children were challenged with gluten after a mean of 5-8 years on gluten-free diets and so far 37 have been confirmed to have coeliac disease by the occurrence of mucosal relapse. In some children, the mucosal relapse was very much slower than in the patients of Packer et al. In one girl after 28 months on gluten the overall appearance of the mucosa was just acceptable as normal and the interepithelial lymphocytes and mucosal disaccharidases were normal; it was not until the 63rd month on gluten that the mucosa was sufficiently abnormal to indicate definite relapse. Throughout this period she showed no haematological abnormalities and remained on the 75th centiles for height and weight."},{"key":"ref_5","article-title":"We strongly reinforce the recommendation of Packer et al. that coeliac disease should not be diagnosed without satisfactory biopsy and agree that it was necessary for them to attempt to prove or disprove the initial diagnosis of coeliac disease (probably made by others) by gluten challenge. However, we would regard the 6 children with normal biopsies after 2 years on gluten as unsatisfactory subjects for allowing conclusions to be drawn concerning gluten intolerance, in the absence of an initial diagnostic biopsy. We agree with them that there are no consistent biochemical, haematological, or anthropometric indices of mucosal relapse. Finally, our experience dictates","volume-title":"that children whose initial mucosa had been definitely abnormal and who had fulfilled other accepted criteria for coeliac disease, must be followed up for considerably longer than 2 years, to allow a primary diagnosis of coeliac disease to be discarded","year":"1978","unstructured":"We strongly reinforce the recommendation of Packer et al. that coeliac disease should not be diagnosed without satisfactory biopsy and agree that it was necessary for them to attempt to prove or disprove the initial diagnosis of coeliac disease (probably made by others) by gluten challenge. However, we would regard the 6 children with normal biopsies after 2 years on gluten as unsatisfactory subjects for allowing conclusions to be drawn concerning gluten intolerance, in the absence of an initial diagnostic biopsy. We agree with them that there are no consistent biochemical, haematological, or anthropometric indices of mucosal relapse. Finally, our experience dictates (Egan-Mitchell et al., 1978) that children whose initial mucosa had been definitely abnormal and who had fulfilled other accepted criteria for coeliac disease, must be followed up for considerably longer than 2 years, to allow a primary diagnosis of coeliac disease to be discarded."}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.53.11.919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:10:00Z","timestamp":1601111400000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.53.11.919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11]]},"references-count":5,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1978,11,1]]},"published-print":{"date-parts":[[1978,11]]}},"alternative-id":["10.1136\/adc.53.11.919"],"URL":"https:\/\/doi.org\/10.1136\/adc.53.11.919","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,11]]}}}