{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:35:41Z","timestamp":1787067341080,"version":"build-2736575974"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1978,4,1]]},"DOI":"10.1136\/adc.53.4.312","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T16:33:49Z","timestamp":1229963629000},"page":"312-315","source":"Crossref","is-referenced-by-count":6,"title":["Normocalcaemic pseudohypoparathyroidism with unusual phenotype."],"prefix":"10.1136","volume":"53","author":[{"given":"J M","family":"Gertner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Gonzalez-Macias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","article-title":"Restoration of the calcium-raising and phosphaturic capabilities of PTH by vitamin D treatment in pseudohypoparathyroidism has been described","volume-title":"the primary cause of PTH resistance lies; This was regarded as evidence that the disease was due to occupation of receptor sites by an abnormal form of PTH. In our case the abnormal cAMP response to injected PTH persisted even after total parathyroidectomy","author":"We suggest that this observation shows that","year":"1975","unstructured":"Restoration of the calcium-raising and phosphaturic capabilities of PTH by vitamin D treatment in pseudohypoparathyroidism has been described (Stogmann and Fischer, 1975). This was regarded as evidence that the disease was due to occupation of receptor sites by an abnormal form of PTH. In our case the abnormal cAMP response to injected PTH persisted even after total parathyroidectomy. We suggest that this observation shows that the primary cause of PTH resistance lies at a renal tubular level rather than in an abnormality of PTH."},{"key":"ref_2","article-title":"The patient's tubular unresponsiveness to PTH may have been exacerbated by a deficiency of 1: 25 dihydroxyvitamin","year":"1976","unstructured":"The patient's tubular unresponsiveness to PTH may have been exacerbated by a deficiency of 1: 25 dihydroxyvitamin D (1: 25 diOHD), shown in pseudohypoparathyroidism by Drezner et al. (1976).","journal-title":"Drezner et al"},{"key":"ref_3","article-title":"Although our patient resembles patients classified by","year":"1976","unstructured":"Although our patient resembles patients classified by Nusynowitz et al. (1976) as 'hypohyperparathyroidism, renal resistance, and skeletal responsiveness to PTH with normal somatic features', he differs in some important respects. His case supports the view that there are many separate disease states which share a degree of resistance to PTH.","journal-title":"Nusynowitz et al; a degree of resistance to PTH; as 'hypohyperparathyroidism, renal resistance, and skeletal responsiveness to PTH with normal somatic features', he differs in some important respects. His case supports the view that there are many separate disease states which share"},{"key":"ref_4","first-page":"922","article-title":"Pseudo-hypoparathyroidism: an example of 'Seabright-Bantam syndrome'","volume":"30","author":"Albright, F.; Burnett, C.H.; Smith, P.H.; Parson, W.","year":"1942","unstructured":"Albright, F., Burnett, C. H., Smith, P. H., and Parson, W. (1942). Pseudo-hypoparathyroidism: an example of 'Seabright-Bantam syndrome'. Endocrinology, 30, 922-932.","journal-title":"Endocrinology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/adc.44.233.96","article-title":"Pseudohypoparathyroidism with raised alkaline phosphatase","volume":"44","author":"Cohen, R.D.; Vince, F.P.","year":"1969","unstructured":"Cohen, R. D., and Vince, F. P. (1969). Pseudohypoparathyroidism with raised alkaline phosphatase. Archives of Disease in Childhood, 44, 96-101.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/adc.38.200.397","volume":"38","author":"Costello, J.M.; Dent, C.E.","year":"1963","unstructured":"Costello, J. M., and Dent, C. E. (1963). Hypo-hyperparathyroidism. Archives of Disease in Childhood, 38, 397-407.","journal-title":"Hypo-hyperparathyroidism. Archives of Disease in Childhood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/jcem-42-4-621","article-title":"1: 25 dihydroxycholecalciferol deficiency: the probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism","volume":"42","author":"Drezner, M.K.; Neelon, F.A.; Haussler, M.; McPherson, H.T.; Lebowitz, H.E.","year":"1976","unstructured":"Drezner, M. K., Neelon, F. A., Haussler, M., McPherson, H. T., and Lebowitz, H. E. (1976). 1:25 dihydroxycholecalciferol deficiency: the probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. Clinical Endocrinology and Metabolism, 42, 621-628.","journal-title":"Clinical Endocrinology and Metabolism"},{"key":"ref_8","first-page":"454","article-title":"The syndromes of parathyroid hormone resistance. Clinical Aspects of Metabolic Bone Disease","author":"Frame, B.; Parfitt, A.M.","year":"1973","unstructured":"Frame, B., and Parfitt, A. M. (1973). The syndromes of parathyroid hormone resistance. Clinical Aspects of Metabolic Bone Disease, pp. 454-464. Ed. by B. Frame, A. M. Parfitt, and H. Duncan. Excerpta Medica, Amsterdam."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00005792-197603000-00001","article-title":"The spectrum ofthe hypoparathyroid states: a classification based on physiologic principles","volume":"55","year":"1976","unstructured":"Nusynowitz, M. L., Frame, B., and Kolb, F. 0. (1976). The spectrum ofthe hypoparathyroid states: a classification based on physiologic principles. Medicine, 55, 105-119.","journal-title":"Medicine"},{"key":"ref_10","first-page":"141","article-title":"Pseudohypoparathyroidism. Disappearance of the resistance to parathyroid extract during treatment with vitamin D","volume":"59","author":"Stogmann, W.; Fischer, J.A.","year":"1975","unstructured":"Stogmann, W., and Fischer, J. A. (1975). Pseudohypoparathyroidism. Disappearance of the resistance to parathyroid extract during treatment with vitamin D. American Journal of Medicine, 59, 141-144.","journal-title":"American Journal of Medicine"},{"key":"ref_11","first-page":"481","article-title":"The effects of exogenous parathyroid hormone on plasma and urinary adenosine 3'5' cyclic monophosphate in man","volume":"47","author":"Tomlinson, S.; Barling, P.M.; Albano, J.D.M.; Brown, B.L.; O'Riordan, J.L.H.","year":"1974","unstructured":"Tomlinson, S., Barling, P. M., Albano, J. D. M., Brown, B. L., and O'Riordan, J. L. H. (1974). The effects of exogenous parathyroid hormone on plasma and urinary adenosine 3'5' cyclic monophosphate in man. Clinical Science and Molecular Medicine, 47, 481-492.","journal-title":"Clinical Science and Molecular Medicine"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.53.4.312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T05:10:35Z","timestamp":1601097035000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.53.4.312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4,1]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.53.4.312","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4,1]]}}}