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P., Gray, 0. P., Elwood, P. C., Hopkinson, C., and Smith, S. (1977). Effects of solid foods on growth of bottle fed infants in first three months oflife. British Medical Journal, 2, 7-8.","journal-title":"British Medical Journal"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1136\/adc.47.256.938","article-title":"Neonatometer: a new infant length measurer","volume":"47","author":"Davies, D.P.; Holding, R.E.","year":"1972","unstructured":"Davies, D. P., and Holding, R. E. (1972). Neonatometer: a new infant length measurer. Archives of Disease in Childhood, 47, 938-940.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_3","article-title":"Present Day Practice in Infant Feeding, Report on Health and Social Subjects, No. 9","author":"Department of Health and Social Security","year":"1974","unstructured":"Department of Health and Social Security (1974). Present Day Practice in Infant Feeding, Report on Health and Social Subjects, No. 9. DHSS: London."},{"key":"ref_4","first-page":"27","author":"Fomon, S.J.","year":"1974","unstructured":"Fomon, S. J. (1974). Infant Nutrition, second edition, pp. 27-31. Saunders: Philadelphia."},{"key":"ref_5","first-page":"1","article-title":"Food consumption and growth of normal infants fed milk-based formulas","volume":"223","author":"Fomon, S.J.; Thomas, L.N.; Filer, L.J.; Ziegler, E.E.; Leonard, M.T.","year":"1971","unstructured":"Fomon, S. J., Thomas, L. N., Filer, L. J., Ziegler, E. E., and Leonard, M. T. (1971). Food consumption and growth of normal infants fed milk-based formulas. Acta paediatrica Scandinavica, 223, Supplement, 1-36.","journal-title":"Acta paediatrica Scandinavica"},{"issue":"8","key":"ref_6","first-page":"3","article-title":"Infant milk powder feeds compared on a common basis","volume":"52","author":"Mettler, A.E.","year":"1976","unstructured":"Mettler, A. E. (1976). Infant milk powder feeds compared on a common basis. Post-Graduate Medical Journal, 52, Supplement 8, 3-20.","journal-title":"Post-Graduate Medical Journal"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/adc.50.8.654","article-title":"Fat absorption by small babies fed two filled milk formulae","volume":"50","author":"Milner, R.D.G.; Deodhar, Y.; Chard, C.R.; Grout, R.M.","year":"1975","unstructured":"Milner, R. D. G., Deodhar, Y., Chard, C. R., and Grout, R. M. (1975). Fat absorption by small babies fed two filled milk formulae. Archives of Disease in Childhood, 50, 654-656.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1079\/BJN19660036","article-title":"The intake and excretion of calorific constituents of milk by babies","volume":"20","author":"Southgate, D.A.T.; Barrett, I.M.","year":"1966","unstructured":"Southgate, D. A. T., and Barrett, I. M. (1966). The intake and excretion of calorific constituents of milk by babies. British Journal of Nutrition, 20, 363-372.","journal-title":"British Journal of Nutrition"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/adc.50.2.142","article-title":"Revised standards for triceps and subscapular skinfolds in British children","volume":"50","author":"Tanner, J.M.; Whitehouse, R.H.","year":"1975","unstructured":"Tanner, J. M., and Whitehouse, R. H. (1975). Revised standards for triceps and subscapular skinfolds in British children. Archives of Disease in Childhood, 50, 142-145.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_10","first-page":"867","article-title":"Comparison of dried milk preparations for babies","volume":"49","author":"Widdowson, E.M.; Southgate, D.A.T.; Schutz, Y.","year":"1974","unstructured":"Widdowson, E. M., Southgate, D. A. T., and Schutz, Y. (1974). Comparison of dried milk preparations for babies on sale in 7 European countries. I. Protein, fat, carbohydrate, and inorganic constituents. Archives'of Disease in Childhood, 49, 867-873.","journal-title":"Archives'of Disease in Childhood; and inorganic constituents"},{"key":"ref_11","article-title":"androgen insensitivity which has specific clinical features (Peterson","year":"1977","unstructured":"androgen insensitivity which has specific clinical features (Peterson et al., 1977). Recognition of the condition is crucial to deciding on the sex of rearing.","journal-title":"et al; Recognition of the condition is crucial to deciding on the sex of rearing"},{"key":"ref_12","article-title":"a-Reductase deficiency causing male pseudohermaphroditism Growth of the phallus, fusion of the labia, and formation of the scrotum in males require the conversion of testosterone to 5-ax-dihydrotestosterone (DHT) at tissue level. The enzyme required for this conversion is 5-xc-reductase which is found in high concentration in fetal urogenital tissue","volume-title":"Testosterone itself brings about obliteration of the lower part of the vagina and descent of the testis. Lack of 5-xc-reductase produces a form of fetal","year":"1975","unstructured":"-a-Reductase deficiency causing male pseudohermaphroditism Growth of the phallus, fusion of the labia, and formation of the scrotum in males require the conversion of testosterone to 5-ax-dihydrotestosterone (DHT) at tissue level. The enzyme required for this conversion is 5-xc-reductase which is found in high concentration in fetal urogenital tissue (Wilson, 1975). Testosterone itself brings about obliteration of the lower part of the vagina and descent of the testis. Lack of 5-xc-reductase produces a form of fetal"},{"issue":"7 3","key":"ref_13","article-title":"mg scrotal skin were incubated as 0*5 mm were reported from Texas","volume-title":"slices in Krebs-Ringer bicarbonate buffer with male pseudohermaphrodites from 24 families have glucose and","volume":"6","author":"(Peterson et al.,","year":"1974","unstructured":"82 mg scrotal skin were incubated as 0*5 mm were reported from Texas (Walsh et al., 1974). 38 slices in Krebs-Ringer bicarbonate buffer with male pseudohermaphrodites from 24 families have glucose and 1, 2, 6, 7 3H testosterone at a concenbeen discovered in 4 villages in the south-western tration of 10-8 mol\/l for 60 minutes at 370C. The section of the Dominican Republic, demonstrating medium and tissue were extracted twice with ethyl a similar defect (Peterson et al., 1977). This case is acetate. 30,g each of testosterone and 5-oc-dihydrothe first reported as originating from Asia and, like testosterone were added to the dried extract and the the other cases, the 5-a-reductase deficiency is mixture was applied to a paper chromatogram and presumed to be inherited as an autosomal recessive run in a descending direction for 16 hours in a (male limited) because our patient has a younger Bush A system."},{"key":"ref_14","article-title":"that in Salinas, in the Dominican Republic, the The infant subsequently underwent a first-stage patients are called guevedoces-penis at 12 years of repair of his perineal hypospadias with correction age","volume-title":"Whether of chordee and removal of prepubic fat to improve dihydrotestosterone is important for growth of the the appearance of the phallus. Examination under internal male organs at puberty is not known, but anaesthetic confirmed absence of muellerian struc-5- a-reduced androgens may play a part in the tures","year":"1974","unstructured":"that in Salinas, in the Dominican Republic, the The infant subsequently underwent a first-stage patients are called guevedoces-penis at 12 years of repair of his perineal hypospadias with correction age (Imperato-McGinley et al., 1974). Whether of chordee and removal of prepubic fat to improve dihydrotestosterone is important for growth of the the appearance of the phallus. Examination under internal male organs at puberty is not known, but anaesthetic confirmed absence of muellerian struc-5- a-reduced androgens may play a part in the tures."},{"key":"ref_15","article-title":"differentiation and maturation of sperm (Wilson, At the end of these investigations the child was","year":"1975","unstructured":"differentiation and maturation of sperm (Wilson, At the end of these investigations the child was 1975)."},{"key":"ref_16","article-title":"as girls in the expectation of female characteristics developing at puberty, as happened in the first Discussion discussed cases. It would be equally wrong to treat such cases as if they had the micropenis syndrome The development of the bipotential fetal gonad at and to consider converting the sex of rearing to a the 6th week of organogenesis is dependent on the female one","volume-title":"Psychosexual sex chromosomes present. A Y-chromosome, even orientation in pubertal patients is male, and sperin an aberrant form, is associated with the presence matogenesis has been demonstrated in a testicular of H-Y antigen which ensures differentiation of a biopsy of an affected subject","author":"(Peterson et al.,","year":"1976","unstructured":"as girls in the expectation of female characteristics developing at puberty, as happened in the first Discussion discussed cases. It would be equally wrong to treat such cases as if they had the micropenis syndrome The development of the bipotential fetal gonad at and to consider converting the sex of rearing to a the 6th week of organogenesis is dependent on the female one (Grant et al., 1976). Psychosexual sex chromosomes present. A Y-chromosome, even orientation in pubertal patients is male, and sperin an aberrant form, is associated with the presence matogenesis has been demonstrated in a testicular of H-Y antigen which ensures differentiation of a biopsy of an affected subject (Peterson et al., 1977)."},{"key":"ref_17","article-title":"system is dependent on testosterone secreted by the testis; development of the external genitalia requires Summary conversion of testosterone to 5-o-dihydrotestosterone at tissue level","year":"1975","unstructured":"system is dependent on testosterone secreted by the testis; development of the external genitalia requires Summary conversion of testosterone to 5-o-dihydrotestosterone at tissue level (Wilson, 1975)."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/adc.51.8.596","article-title":"HCG stimulation test in children with abnormal sexual development","volume":"51","author":"Grant, D.B.; Laurance, B.M.; Atherden, S.M.; Ryness, J.","year":"1976","unstructured":"Grant, D. B., Laurance, B. M., Atherden, S. M., and Ryness, J. (1976). HCG stimulation test in children with abnormal sexual development. Archives of Disease in Childhood, 51, 596-601.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1126\/science.186.4170.1213","article-title":"Steroid 5-x-reductase deficiency in man: an inherited form of male pseudohermaphroditism","volume":"186","author":"Imperato-McGinley, J.; Guerrero, L.; Gautier, T.; Peterson, R.E.","year":"1974","unstructured":"Imperato-McGinley, J., Guerrero, L., Gautier, T., and Peterson, R. E. (1974). Steroid 5-x-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science, 186, 1213-1215.","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0002-9343(77)90313-8","article-title":"Male pseudohermaphroditism due to steroid 5-a-reductase deficiency","volume":"62","author":"Peterson, R.E.; Imperato-McGinley, J.; Gautier, T.; Sturla, E.","year":"1977","unstructured":"Peterson, R. E., Imperato-McGinley, J., Gautier, T., and Sturla, E. (1977). Male pseudohermaphroditism due to steroid 5-a-reductase deficiency. American Journal of Medicine, 62, 170-190.","journal-title":"American Journal of Medicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1056\/NEJM197410312911806","article-title":"Familial incomplete male pseudohermaphroditism, type 2","volume":"291","author":"Walsh, P.C.; Madden, J.D.; Harrod, M.J.; Goldstein, J.L.; Macdonald, P.C.; Wilson, J.D.","year":"1974","unstructured":"Walsh, P. C., Madden, J. D., Harrod, M. J., Goldstein, J. L., Macdonald, P. C., and Wilson, J. D. (1974). Familial incomplete male pseudohermaphroditism, type 2. New England Journal of Medicine, 291, 944-949.","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"ref_22","first-page":"491","article-title":"Metabolism of testicular androgens","volume-title":"Handbook ofPhysiology, section","volume":"7","author":"Wilson, J.D.","year":"1975","unstructured":"Wilson, J. D. (1975). Metabolism of testicular androgens. In Handbook ofPhysiology, section 7, volume 5, chapter 25, pp. 491-508. American Physiological Society: Washington DC."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1172\/JCI105994","article-title":"The conversion of testosterone to 5-androstan-17-01-3-one (dihydrotestosterone) by skin slices of man","volume":"48","author":"Wilson, J.D.; Walker, J.D.","year":"1969","unstructured":"Wilson, J. D., and Walker, J. D. (1969). The conversion of testosterone to 5-androstan-17-01-3-one (dihydrotestosterone) by skin slices of man. Journal of Clinical Investigation, 48, 371-379.","journal-title":"Journal of Clinical Investigation"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.53.9.751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:11:38Z","timestamp":1601111498000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.53.9.751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9,1]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1978,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.53.9.751","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,9,1]]}}}