{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:40:19Z","timestamp":1760298019969},"reference-count":16,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1979,12,1]]},"DOI":"10.1136\/adc.54.12.986","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:33:49Z","timestamp":1229981629000},"page":"986-987","source":"Crossref","is-referenced-by-count":27,"title":["Neutropenia during sodium valproate treatment."],"prefix":"10.1136","volume":"54","author":[{"given":"J","family":"Jaeken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"van Goethem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Casaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Devlieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Eggermont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pilet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"335","article-title":"The effect of age upon the entry of some amino acids into the brain, early pregnancy. Delivery took place at term, the healthy and their incorporation into cerebral protein. Developboy (weight 3440 g, Apgar score 9\/10) did not show any mental","volume":"20","year":"1978","unstructured":"Banos, G., Daniel, P. M., and Pratt, 0. E. (1978). The effect of age upon the entry of some amino acids into the brain, early pregnancy. Delivery took place at term, the healthy and their incorporation into cerebral protein. Developboy (weight 3440 g, Apgar score 9\/10) did not show any mental Medicine and Child Neurology, 20, 335-346.","journal-title":"Medicine and Child Neurology"},{"key":"ref_2","first-page":"617","article-title":"Letter: Dipropylacetate (valproate) and glycine metabolism","volume":"2","author":"E.; Eeckels, R.","year":"1977","unstructured":"E., and Eeckels, R. (1977). Letter: Dipropylacetate (valproate) and glycine metabolism. Lancet, 2, 617.","journal-title":"Lancet"},{"key":"ref_3","article-title":"Effect du n-dipropyl","author":"Kamoun, P.; Parvy, P.","year":"1978","unstructured":"Kamoun, P., and Parvy, P. 1978). Effect du n-dipropyl"},{"key":"ref_4","article-title":"epilepsy since 1968, was started on SV in January","volume-title":"Cerebral amino","author":"Seta, K.; Sershen, H.; Lajtha, A.","year":"1978","unstructured":"epilepsy since 1968, was started on SV in January 1978 Seta, K., Sershen, H., and Lajtha, A. (1972). Cerebral amino"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-0028-1085322","volume":"10","author":"Simila, S.; von Wendt, L.; Linna, S.-L.; Saukkonen, A.-L.; Huhtaniemi, I.","year":"1979","unstructured":"Simila, S., von Wendt, L., Linna, S-L., Saukkonen, A-L, and Huhtaniemi, I. (1979). Dipropylacetate and hyperglycinemia. Neuropaediatrie, 10, 158-160.","journal-title":"Dipropylacetate and hyperglycinemia. Neuropaediatrie"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4684-2673-1_3","article-title":"Disorders of organic acid metabolism","volume":"3","author":"Tanaka, K.","year":"1975","unstructured":"Tanaka, K. (1975). Disorders of organic acid metabolism. Biological Brain Dysfunction, 3, 145-215.","journal-title":"Biological Brain Dysfunction"},{"key":"ref_7","first-page":"360","article-title":"The serum level of SV was measured in the mothers at delivery and in the neonates at birth and repeatedly postnatally. At birth, SV levels were 220 and 110, umol\/l in the neonates","volume":"9","author":"von Wendt, L.","year":"1978","unstructured":"The serum level of SV was measured in the mothers at delivery and in the neonates at birth and repeatedly postnatally. At birth, SV levels were 220 and 110,umol\/l in the neonates, and 200 and 210,umol\/l in the mothers, von Wendt, L., Similia, S., Hirvasniemi, A., and Suvanto, E. (1978). Altered levels of various amino acids in blood plasma and cerebrospinal fluid of patients with nonketotic hyperglycinemia. Neuropaediatrie, 9, 360-368.","journal-title":"Neuropaediatrie; and 210, umol\/l in the mothers"},{"key":"ref_8","article-title":"Finland From these 2 case histories it is concluded that the use of SV in the last trimester ofpregnancy induces a transient secondary hyperglycinaemia in the neonatal period, Neutropenia during sodium valproate although the plasma glycine concentrations are clearly lower than in nonketotic hyperglycinaemia or organic acidaemia associated with hyperglycinaemia","author":"22, Oulu","year":"1975","unstructured":"Oulu 22, Finland From these 2 case histories it is concluded that the use of SV in the last trimester ofpregnancy induces a transient secondary hyperglycinaemia in the neonatal period, Neutropenia during sodium valproate although the plasma glycine concentrations are clearly lower than in nonketotic hyperglycinaemia or organic acidaemia associated with hyperglycinaemia (Tanaka, 1975; von Wendt et al., 1978). As these infants show normal psychomotor development, it is evident that this moderate rise of glycine concentration does not impair treatment","journal-title":"Wendt et al; As these infants show normal psychomotor development"},{"key":"ref_9","article-title":"Thrombocytopenia is a well-known side effect of sodium valproate (dipropylacetic acid) treatment","volume-title":"As far as we know, neutropenia has not been documented during valproate medication. Recently we treated a","author":"Sir","year":"1978","unstructured":"Sir, Thrombocytopenia is a well-known side effect of sodium valproate (dipropylacetic acid) treatment (Winfield et al., 1976; Raworth and Birchall, 1978; Sandler et al., 1978). As far as we know, neutropenia has not been documented during valproate medication. Recently we treated a"},{"key":"ref_10","first-page":"617","article-title":"Letter: Dipropylacetate (valproate) and glycine metabolism","volume":"2","author":"Jaeken, J.; Corbeel, L.; Casaer, P.; Carchon, H.; Eggermont, E.; Eeckels, R.","year":"1977","unstructured":"Jaeken, J., Corbeel, L., Casaer, P., Carchon, H., Eggermont, E., and Eeckels, R. (1977). Letter: Dipropylacetate (valproate) and glycine metabolism. Lancet, 2, 617.","journal-title":"Lancet"},{"key":"ref_11","first-page":"2162","article-title":"Hyperglycinurie induite par le n-dipropyl ac6tate: modele possible de l'acidemie propionique","volume":"6","author":"Kamoun, P.; Parvy, P.; Debray-Ritzen, P.","year":"1977","unstructured":"Kamoun, P., Parvy, P., and Debray-Ritzen, P. (1977). Hyperglycinurie induite par le n-dipropyl ac6tate: modele possible de l'acidemie propionique. Nouvelle presse medicale, 6, 2162.","journal-title":"Nouvelle presse medicale"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0140-6736(78)91187-X","article-title":"Letter: Sodium valproate and platelet-count","volume":"1","author":"Raworth, R.; Birchall, G.","year":"1978","unstructured":"Raworth, R., and Birchall, G. (1978). Letter: Sodium valproate and platelet-count. Lancet, 1, 670-671.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1136\/bmj.2.6153.1683","article-title":"IgM platelet autoantibody due to sodium valproate","volume":"2","author":"Sandler, R.; Emberson, C.; Roberts, G.; Voak, D.; Darnborough, J.; Heeley, A.","year":"1978","unstructured":"Sandler, R., Emberson, C., Roberts, G., Voak, D., Darnborough, J., and Heeley, A. (1978). IgM platelet autoantibody due to sodium valproate. British Medical Journal, 2, 1683-1684.","journal-title":"British Medical Journal"},{"key":"ref_14","first-page":"273","article-title":"Disorders of branchedchain amino acid oxidation without accumulation of free amino acid","volume-title":"Amino Acid Metabolism and Its Disorders","author":"Scriver, C.; Rosenberg, L.","year":"1973","unstructured":"Scriver, C., and Rosenberg, L. (1973). Disorders of branchedchain amino acid oxidation without accumulation of free amino acid. In Amino Acid Metabolism and Its Disorders, p. 273-289. Edited by A. Schaffer. Saunders: Philadelphia."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1528-1157.1975.tb04738.x","article-title":"Sodium di N propylacetate (DPA) in the treatment of epilepsy","volume":"16","author":"Simon, D.; Penry, J.","year":"1975","unstructured":"Simon, D., and Penry, J. (1975). Sodium di N propylacetate (DPA) in the treatment of epilepsy. Epilepsia, 16, 549-573.","journal-title":"Epilepsia"},{"issue":"981","key":"ref_16","article-title":"Sodium valproate and thrombocytopenia","volume":"2","author":"Winfield, D.A.; Benton, P.; Espir, M.E.; Arthur, L.J.H.","year":"1976","unstructured":"Winfield, D. A., Benton, P., Espir, M. E., and Arthur, L. J. H. (1976). Sodium valproate and thrombocytopenia. British MedicalJournal, 2,981.","journal-title":"British MedicalJournal"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.54.12.986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:12:35Z","timestamp":1601111555000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.54.12.986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12,1]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1979,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.54.12.986","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,12,1]]}}}