{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:10:48Z","timestamp":1775913048659,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1981,3,1]]},"DOI":"10.1136\/adc.56.3.218","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:33:49Z","timestamp":1229981629000},"page":"218-222","source":"Crossref","is-referenced-by-count":20,"title":["Effect of cyproterone acetate on adrenocortical function in children with precocious puberty."],"prefix":"10.1136","volume":"56","author":[{"given":"D C","family":"Savage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Swift","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"issue":"58","key":"ref_1","first-page":"672","article-title":"Idiopathic precocious puberty: indication for therapeutic use particular the cause of its increased production at puberty is not known. One suggestion has been that a gonadotrophin, possibly luteinising hormone, may be concerned, perhaps synergistically, with ACTH or of cyproterone acetate, an antigonadotrophic and antiandrogenic substance (abstract)","volume":"1969","author":"Helge, H.; Weber, B.; Hammerstein, J.; Neumann, F.","unstructured":"Helge H, Weber B, Hammerstein J, Neumann F. Idiopathic precocious puberty: indication for therapeutic use particular the cause of its increased production at puberty is not known. One suggestion has been that a gonadotrophin, possibly luteinising hormone, may be concerned, perhaps synergistically, with ACTH or of cyproterone acetate, an antigonadotrophic and antiandrogenic substance (abstract). Acta Paediatr Scand 1969; 58: 672.","journal-title":"Acta Paediatr Scand"},{"key":"ref_2","first-page":"399","article-title":"The treatment of precocious puberty with cyproterone acetate. Acta another pituitary hormone.2022 The unequal effect of Endocrinol","volume":"74","author":"Rager, K.; Huenges, R.; Gupta, D.; R, Bierich J.","year":"1972","unstructured":"Rager K, Huenges R, Gupta D, Bierich J R. The treatment of precocious puberty with cyproterone acetate. Acta another pituitary hormone.2022 The unequal effect of Endocrinol (Kbh) 1972; 74: 399-408.","journal-title":"(Kbh)"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1210\/jcem-42-3-551","article-title":"Effect of cyproterone acetate on gonadotrophin response to synthetic luteinizing hormone-releasing hormone (LRH) in girls with idiopathic precocious puberty","volume":"42","author":"Angeli, A.; Boccuzzi, G.; Bisbocci, D.","year":"1976","unstructured":"Angeli A, Boccuzzi G, Bisbocci D, et al. Effect of cyproterone acetate on gonadotrophin response to synthetic luteinizing hormone-releasing hormone (LRH) in girls with idiopathic precocious puberty. J Clin Endocrinol Metab 1976; 42: 551-60.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1203\/00006450-197404000-00006","article-title":"Treatment of precocious puberty with cyproterone acetate","volume":"8","author":"A, Werder E.; G, Murset; M, Zachmann; D, Brook C.G.; A, Prader","year":"1974","unstructured":"Werder E A, Murset G, Zachmann M, Brook C G D, Prader A. Treatment of precocious puberty with cyproterone acetate. Pediatr Res 1974; 8: 248-56.","journal-title":"Pediatr Res"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0028-1093574","article-title":"Pharmacology and potential use of cyproterone acetate","volume":"9","author":"Neumann, F.","year":"1977","unstructured":"Neumann F. Pharmacology and potential use of cyproterone acetate. Horm Metab Res 1977; 9: 1-13.","journal-title":"Horm Metab Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0022-3476(71)80463-8","article-title":"The effect of medroxyprogesterone acetate on adrenocortical function in children with precocious puberty","volume":"78","author":"Sadeghi-Nejad, A.; L, Kaplan S.; M, Grumbach M.","year":"1971","unstructured":"Sadeghi-Nejad A, Kaplan S L, Grumbach M M. The effect of medroxyprogesterone acetate on adrenocortical function in children with precocious puberty. J Pediatr 1971; 78: 616-24.","journal-title":"J Pediatr"},{"key":"ref_7","first-page":"414","article-title":"Vergleich der Wirkung der antiadrogen Cyproteron und Cyproteron-acetate auf des endokrine System der Ratten","volume":"58","author":"Schreiber, V.; Pribyl, T.; Rohacova, J.","year":"1971","unstructured":"Schreiber V, Pribyl T, Rohacova J. Vergleich der Wirkung der antiadrogen Cyproteron und Cyproteron-acetate auf des endokrine System der Ratten. Endokrinologie 1971; 58: 414-24.","journal-title":"Endokrinologie"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1530\/acta.0.0820127","article-title":"The effect of cyproterone acetate on the adrenal of the male hamster","volume":"82","author":"Zeiger, G.; Lux, B.; Kubatsch, B.","year":"1976","unstructured":"Zeiger G, Lux B, Kubatsch B. The effect of cyproterone acetate on the adrenal of the male hamster. Acta Endocrinol 1976; 82: 127-33.","journal-title":"Acta Endocrinol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/0014-2999(67)90107-0","article-title":"Biological studies on an antiandrogen","volume":"1","year":"1967","unstructured":"Neri R 0, Monahan M 0, Meyer J G, Alfonso B A, Tabachnik J A. Biological studies on an antiandrogen (SH 714). Eur J Clin Pharmacol 1967; 1: 438-44.","journal-title":"Eur J Clin Pharmacol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1210\/endo-83-5-945","article-title":"Paradoxical effects of androgen antagonist cyproterone acetate on steroid metabolism in the rat","volume":"83","author":"Denef, K.; Vandeputte, M.; De Moor, P.","year":"1968","unstructured":"Denef K, Vandeputte M, De Moor P. Paradoxical effects of androgen antagonist cyproterone acetate on steroid metabolism in the rat. Endocrinology 1968; 83: 945-55.","journal-title":"Endocrinology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1203\/00006450-197508000-00029","article-title":"Secondary adrenal insufficiency due to cyproterone acetate (abstract)","volume":"9","author":"Girard, J.; B, Baumann J.","year":"1975","unstructured":"Girard J, Baumann J B. Secondary adrenal insufficiency due to cyproterone acetate (abstract). Pediatr Res 1975; 9: 669.","journal-title":"Pediatr Res"},{"key":"ref_12","first-page":"1160","article-title":"Letter: Cyproterone acetate and adrenocortical function","volume":"i:","author":"E, Von Mukhlendahl K.; S, Korth-Schutz; R, Muller-Hess; H, Helge; B, Weber","year":"1977","unstructured":"Von Mukhlendahl K E, Korth-Schutz S, Muller-Hess R, Helge H, Weber B. Letter: Cyproterone acetate and adrenocortical function. Lancet 1977; i: 1160-1.","journal-title":"Lancet"},{"issue":"140","key":"ref_13","article-title":"Letter: Cyproterone acetate","volume":"1","author":"J, Jeffcoate W.","year":"1976","unstructured":"Jeffcoate W J, Edwards C R W, Rees L H, Besser G M. Letter: Cyproterone acetate. Lancet 1976;'ii:1 140.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1007\/BF01945829","article-title":"Corticosteroid-like effect of cyproterone and cyproterone acetate in mice","volume":"31","author":"D, Brouli K.P.; L, Stdrka","year":"1975","unstructured":"Brouli K P D, Stdrka L. Corticosteroid-like effect of cyproterone and cyproterone acetate in mice. Experientia 1975; 31: 1364-5.","journal-title":"Experientia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1530\/acta.0.0810680","article-title":"The effect of cyproterone acetate on the plasma gonadotrophin response to gonadotrophin releasing hormone","volume":"81","author":"A, Donald R.; A, Espiner E.; J, Cowles R.; E, Fazackerley J.","year":"1976","unstructured":"Donald R A, Espiner E A, Cowles R J, Fazackerley J E. The effect of cyproterone acetate on the plasma gonadotrophin response to gonadotrophin releasing hormone. Acta Endocrinol 1976; 81: 680-4.","journal-title":"Acta Endocrinol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/jrf.0.0260059","article-title":"Effect of cyproterone acetate on puberty in rats","volume":"26","author":"Steinbeck, H.; Neumann, F.","year":"1971","unstructured":"Steinbeck H, Neumann F. Effect of cyproterone acetate on puberty in rats. J Rep Fertil 1971; 26: 59-63.","journal-title":"J Rep Fertil"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1203\/00006450-197610000-00086","article-title":"Longitudinal study of the gonadotrophin response to luteinizing hormone releasing hormone in children with precocious puberty treated with cyproterone acetate (abstract)","volume":"10","author":"L, Savage D.C.; J, Goldie D.","year":"1976","unstructured":"Savage D C L, Goldie D J. Longitudinal study of the gonadotrophin response to luteinizing hormone releasing hormone in children with precocious puberty treated with cyproterone acetate (abstract). Pediatr Res 1976; 10: 886.","journal-title":"Pediatr Res"},{"key":"ref_18","series-title":"Proceedings of the Second Clinical ACTH Conference","first-page":"20","article-title":"Concerning the probability that there are at least two adrenocorticotrophic hormones in the human being","volume":"1","author":"B, Talbot N.; S, Wood M.; M, Campbell A.; E, Christo; S, Zygmuntowicz A.","year":"1951","unstructured":"Talbot N B, Wood M S, Campbell A M, Christo E, Zygmuntowicz A S. Concerning the probability that there are at least two adrenocorticotrophic hormones in the human being. In: Mote J R, ed. Proceedings of the Second Clinical ACTH Conference. Vol. 1. London: Churchill, 1951: 20-31."},{"key":"ref_19","first-page":"204","article-title":"The relationship between the production of cortisol and of androgens by the human adrenal","author":"H, Mills I.; V, Brooks R.; G, Prunty F.T.","year":"1962","unstructured":"Mills I H, Brooks R V, Prunty F T G. The relationship between the production of cortisol and of androgens by the human adrenal. In: Currie A R, Symington T, Grant J K, eds. The human adrenal cortex. London: Livingstone, 1962: 204-16."},{"key":"ref_20","first-page":"379","article-title":"Effects of human pituitary extracts on androgen biosynthesis by human adrenals in vitro","volume":"48","author":"J, Milner A.; H, Mills I.","year":"1970","unstructured":"Milner A J, Mills I H. Effects of human pituitary extracts on androgen biosynthesis by human adrenals in vitro. JEndocrinol 1970; 48: 379-87.","journal-title":"JEndocrinol"},{"key":"ref_21","first-page":"138","article-title":"Urinary androgen response of 8 girls with precocious puberty given cyproterone acetate","volume":"65","author":"Gupta, D.; Rager, K.; Huenges, R.; R, Bierich J.","year":"1975","unstructured":"Gupta D, Rager K, Huenges R, Bierich J R. Urinary androgen response of 8 girls with precocious puberty given cyproterone acetate. Endokrinologie 1975; 65: 138-44.","journal-title":"Endokrinologie"},{"key":"ref_22","article-title":"Growth at adolescence; with a general consideration of the effects of hereditary and environmental factors upon growth and maturation from birth to maturity, second edition","author":"M, Tanner J.","year":"1962","unstructured":"Tanner J M. Growth at adolescence; with a general consideration of the effects of hereditary and environmental factors upon growth and maturation from birth to maturity, second edition. Oxford: Blackwell, 1962."}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.56.3.218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T23:41:28Z","timestamp":1601077288000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.56.3.218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3,1]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.56.3.218","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3,1]]}}}