{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:16:11Z","timestamp":1761488171794},"reference-count":46,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1982,3,1]]},"DOI":"10.1136\/adc.57.3.176","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T21:51:33Z","timestamp":1229982693000},"page":"176-183","source":"Crossref","is-referenced-by-count":45,"title":["Brain-orientated intensive care treatment in severe neonatal asphyxia. Effects of phenobarbitone protection."],"prefix":"10.1136","volume":"57","author":[{"given":"N W","family":"Svenningsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lindroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P O","family":"Gaddlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ahlstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/adc.50.9.696","article-title":"Perinatal cardiac arrest. Quality of the survivors","volume":"50","author":"Steiner, H.; Neligan, G.","year":"1975","unstructured":"Steiner H, Neligan G. Perinatal cardiac arrest. Quality of the survivors. Arch Dis Child 1975; 50: 696-702.","journal-title":"Arch Dis Child"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/adc.51.9.712","article-title":"Outcome of very severe birth asphyxia","volume":"51","author":"Scott, H.","year":"1976","unstructured":"Scott H. Outcome of very severe birth asphyxia. Arch Dis Child 1976; 51: 712-6.","journal-title":"Arch Dis Child"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/adc.52.8.620","article-title":"Quality of survival after severe birth asphyxia","volume":"52","author":"J, Thomson A.; M, Searle; G, Russell","year":"1977","unstructured":"Thomson A J, Searle M, Russell G. Quality of survival after severe birth asphyxia. Arch Dis Child 1977; 52: 620-6.","journal-title":"Arch Dis Child"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/adc.53.7.564","article-title":"Neurological sequelae in newborn babies after perinatal asphyxia","volume":"53","author":"deSouza S W; B, Richards","year":"1978","unstructured":"deSouza S W, Richards B. Neurological sequelae in newborn babies after perinatal asphyxia. Arch Dis Child 1978; 53: 564-9.","journal-title":"Arch Dis Child"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0022-3476(80)80575-0","article-title":"Neonatal asphyxia. II. Neonatal mortality and long-term sequelae","volume":"96","author":"C, Mulligan J.; J, Painter M.; A, O.'Donoghue P.; M, MacDonald H.; C, Allen A.; M, Taylor P.","year":"1980","unstructured":"Mulligan J C, Painter M J, O'Donoghue P A, MacDonald H M, Allen A C, Taylor P M. Neonatal asphyxia. II. Neonatal mortality and long-term sequelae. J Pediatr 1980; 96: 903-7.","journal-title":"J Pediatr"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1651-2227.1975.tb03929.x","article-title":"Respiratory insufficiency syndrome (RIS) in preterm infants with gestational age of 32 weeks and less","volume":"64","author":"Carlsson, J.; W, Svenningsen N.","year":"1975","unstructured":"Carlsson J, Svenningsen N W. Respiratory insufficiency syndrome (RIS) in preterm infants with gestational age of 32 weeks and less. Acta Paediatr Scand 1975; 64: 813-21.","journal-title":"Acta Paediatr Scand"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1651-2227.1980.tb07051.x","article-title":"Evaluation of mechanical ventilation in newborn infants. I. Techniques and survival rates","volume":"69","year":"1980","unstructured":"Evaluation of mechanical ventilation in newborn infants. I. Techniques and survival rates. Acta Paediatr Scand 1980; 69: 143-9.","journal-title":"Acta Paediatr Scand"},{"key":"ref_8","first-page":"186","article-title":"Neonatal and prospective follow-up study of infants delivered by vacuum extraction (VE)","volume":"56","author":"Blennow, G.; W, Svenningsen N.; Gustafson, B.; Sunden, B.; Cronquist, S.","year":"1977","unstructured":"Blennow G, Svenningsen N W, Gustafson B, Sunden B, Cronquist S. Neonatal and prospective follow-up study of infants delivered by vacuum extraction (VE). Acta Obstet Gynecol Scand 1977; 56: 186-94.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"64","key":"ref_9","first-page":"144","article-title":"Thiopental amelioration of postischemic encephalopathy in monkeys","volume":"56","author":"L, Bleyaert A.; M, Nemoto E.; P, Safar","year":"1977","unstructured":"Bleyaert A L, Nemoto E M, Safar P, et al. Thiopental amelioration of postischemic encephalopathy in monkeys. Acta Neurol Scand [Suppl] 1977; 56: Supplement 64, 144-5.","journal-title":"Acta Neurol Scand [Suppl]"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1203\/00006450-197504000-00008","article-title":"The effect of phenobarbital on asphyxia in the newborn monkey","volume":"9","author":"E, Fisher D.; B, Paton J.; E, Behrman R.","year":"1975","unstructured":"Fisher D E, Paton J B, Behrman R E. The effect of phenobarbital on asphyxia in the newborn monkey. Pediatr Res 1975; 9: 181-4.","journal-title":"Pediatr Res"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1001\/archneur.1976.00500050031006","article-title":"Cerebral protection by barbiturate anesthesia","volume":"33","author":"D, Michenfelder J.; H, Milde J.; M, Jr, Sundt T.","year":"1976","unstructured":"Michenfelder J D, Milde J H, Sundt T M, Jr. Cerebral protection by barbiturate anesthesia. Arch Neurol 1976; 33: 345-50.","journal-title":"Arch Neurol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0031-3955(16)32484-1","article-title":"Barbiturates and asphyxia","volume":"17","author":"W, Brann A.; M, Montalvo J.","year":"1970","unstructured":"Brann A W, Montalvo J M. Barbiturates and asphyxia. Pediatr Clin N Am 1970; 17: 851-62.","journal-title":"Pediatr Clin N Am"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/00365518009095568","article-title":"Barbiturate protection against ischemic brain damage","volume":"40","author":"Renck, H.","year":"1980","unstructured":"Renck H. Barbiturate protection against ischemic brain damage. Scand J Clin Lab Invest 1980; 40: 209-10.","journal-title":"Scand J Clin Lab Invest"},{"issue":"64","key":"ref_14","first-page":"156","article-title":"Barbiturate control of intracranial hypertension in head injury and other conditions: iatrogenic coma","volume":"56","author":"F, Marshall L.; M, Shapiro H.","year":"1977","unstructured":"Marshall L F, Shapiro H M. Barbiturate control of intracranial hypertension in head injury and other conditions: iatrogenic coma. Acta Neurol Scand 1977; 56: Supplement 64, 156-72.","journal-title":"Acta Neurol Scand"},{"key":"ref_15","first-page":"222","article-title":"Clinical feasibility of trials of barbiturate therapy after cardiac arrest","volume":"6","author":"Breivik, H.; Safar, P.; Sands, P.","year":"1978","unstructured":"Breivik H, Safar P, Sands P, et al. Clinical feasibility of trials of barbiturate therapy after cardiac arrest. Crit Care Med 1978; 6: 222-44.","journal-title":"Crit Care Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0022-3476(69)80399-9","article-title":"The effect of phenobarbital anesthesia on resuscitation and brain damage in fetal rhesus monkeys asphyxiated on delivery","volume":"75","author":"Cockburn, F.; Daniel, S.; Dawes, G.","year":"1969","unstructured":"Cockburn F, Daniel S, Dawes G, et al. The effect of phenobarbital anesthesia on resuscitation and brain damage in fetal rhesus monkeys asphyxiated on delivery. J Pediatr 1969; 75: 281-91.","journal-title":"J Pediatr"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1399-6576.1975.tb05408.x","article-title":"The effect of phenobarbitone anaesthesia on blood flow and oxygen consumption in the rat brain","volume":"57","author":"Nilsson, L.; K, Siesjo B.","year":"1975","unstructured":"Nilsson L, Siesjo B K. The effect of phenobarbitone anaesthesia on blood flow and oxygen consumption in the rat brain. Acta Anaesthesiol Scand 1975; Supplement 57, 18-24.","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref_18","first-page":"357","article-title":"Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the newborn calf and lamb","volume":"305","author":"M, Gardiner R.","year":"1980","unstructured":"Gardiner R M. Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the newborn calf and lamb. JPhysiol 1980; 305: 357-76.","journal-title":"JPhysiol"},{"issue":"64","key":"ref_19","first-page":"148","article-title":"Rate of rise in extracellular potassium in the ischemic rat brain and the effect of pre-ischemic metabolic rate. Evidence for a specific effect of phenobarbitone","volume":"56","author":"Astrup, J.; Nordstrom, C.-H.; Rehncrona, S.","year":"1977","unstructured":"Astrup J, Nordstrom C-H, Rehncrona S. Rate of rise in extracellular potassium in the ischemic rat brain and the effect of pre-ischemic metabolic rate. Evidence for a specific effect of phenobarbitone. Acta Neurol Scand 1977; 56: Supplement 64, 148-9.","journal-title":"Acta Neurol Scand"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0028-1091482","article-title":"Neonatal seizures and brain growth","volume":"9","author":"G, Wasterlain C.","year":"1978","unstructured":"Wasterlain C G. Neonatal seizures and brain growth. Neuropaediatrie 1978; 9: 213-28.","journal-title":"Neuropaediatrie"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/00365518009095567","article-title":"Barbiturate protection against ischemic brain damage","volume":"40","author":"A, Steen P.","year":"1980","unstructured":"Steen P A. Barbiturate protection against ischemic brain damage. Scand J Clin Lab Invest 1980; 40: 205-7.","journal-title":"Scand J Clin Lab Invest"},{"key":"ref_22","first-page":"8","article-title":"Ischemic brain edema: comparative effects of barbiturates and hypothermia","volume":"10","author":"A, Simeone F.; G, Frazer; P, Lawner","year":"1978","unstructured":"Simeone F A, Frazer G, Lawner P. Ischemic brain edema: comparative effects of barbiturates and hypothermia. Stroke 1978; 10: 8-12.","journal-title":"Stroke"},{"issue":"64","key":"ref_23","first-page":"152","article-title":"Antioxidant effects of barbiturates in model membranes undergoing free radical damage","volume":"56","author":"B, Demopoulos H.; S, Flamm E.; L, Seligman M.; E, Jorgensen; J, Ransohoff","year":"1977","unstructured":"Demopoulos H B, Flamm E S, Seligman M L, Jorgensen E, Ransohoff J. Antioxidant effects of barbiturates in model membranes undergoing free radical damage. Acta Neurol Scand 1977; 56: Supplement 64, 152-3.","journal-title":"Acta Neurol Scand"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00000542-198009000-00002","article-title":"Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro","volume":"53","author":"S, Smith D.; S, Rehncrona; K, Siesjo B.","year":"1980","unstructured":"Smith D S, Rehncrona S, Siesjo B K. Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro. Anesthesiology 1980; 53: 186-94.","journal-title":"Anesthesiology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0022-3476(79)80373-X","article-title":"Impaired autoregulation of cerebral blood flow in the distressed newborn infant","volume":"94","author":"C, Lou H.; A, Lassen N.; B, Friis-Hansen","year":"1979","unstructured":"Lou H C, Lassen N A, Friis-Hansen B. Impaired autoregulation of cerebral blood flow in the distressed newborn infant. J Pediatr 1979; 94: 118-21.","journal-title":"J Pediatr"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/ana.410010604","article-title":"Cerebral metabolism in newborn dogs during reversible asphyxia","volume":"1","author":"C, Vannucci R.; E, Duffy T.","year":"1977","unstructured":"Vannucci R C, Duffy T E. Cerebral metabolism in newborn dogs during reversible asphyxia. Ann Neurol 1977; 1: 528-34.","journal-title":"Ann Neurol"},{"key":"ref_27","first-page":"56","article-title":"Brain energy metabolism","author":"K, Siesjo B.","year":"1978","unstructured":"Siesjo B K. Brain energy metabolism. New York: Wiley, 1978: 56-100."},{"key":"ref_28","first-page":"23","article-title":"Diagnostic et 6volution de la souffrance cerebrale chez les nouveu-nes ayant present6 des signes d'hypoxie foetale. Etude prospective","volume":"35","author":"Andre, M.; Vert, P.; Ch, Debruille","year":"1978","unstructured":"Andre M, Vert P, Debruille Ch. Diagnostic et 6volution de la souffrance cerebrale chez les nouveu-nes ayant present6 des signes d'hypoxie foetale. Etude prospective. Arch Fr Pediatr 1978; 35: 23-36.","journal-title":"Arch Fr Pediatr"},{"key":"ref_29","first-page":"567","article-title":"Neurological aspects of perinatal asphyxia","volume":"16","author":"G, Brierley J.B.","year":"1975","unstructured":"Brown J K, Purvis R J, Forfar J 0, Cockburn F. Neurological aspects of perinatal asphyxia. Dev Med Child Neurol 1975; 16: 567-71. 'I Blennow G, Brierley J B, Meldrum B S, Siesjd B K.","journal-title":"Dev Med Child Neurol; I Blennow"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/brain\/101.4.687","article-title":"Epileptic brain damage: the role of systemic factors that modify cerebral energy metabolism","volume":"101","year":"1978","unstructured":"Epileptic brain damage: the role of systemic factors that modify cerebral energy metabolism. Brain 1978; 101: 687-700.","journal-title":"Brain"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archneur.1973.00490260026003","article-title":"Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed artificially ventilated baboons","volume":"29","author":"S, Meldrum B.; A, Vigouroux R.; B, Brierley J.","year":"1973","unstructured":"Meldrum B S, Vigouroux R A, Brierley J B. Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed artificially ventilated baboons. Arch Neurol 1973; 29: 82-7.","journal-title":"Arch Neurol"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1651-2227.1975.tb03873.x","article-title":"Plasma concentrations of phenobarbital in the treatment of seizures in newborns","volume":"64","author":"Jalling, B.","year":"1975","unstructured":"Jalling B. Plasma concentrations of phenobarbital in the treatment of seizures in newborns. Acta Paediatr Scand 1975; 64: 514-24.","journal-title":"Acta Paediatr Scand"},{"key":"ref_33","first-page":"383","article-title":"Perinatal hypoxic-ischemic brain injury. Pediatr Clin NAm","volume":"23","author":"J, Volpe J.","year":"1976","unstructured":"Volpe J J. Perinatal hypoxic-ischemic brain injury. Pediatr Clin NAm 1976; 23: 383-97."},{"key":"ref_34","first-page":"59","article-title":"Infants damaged during birth. Perinatal asphyxia","volume-title":"advances in paediatrics, fifth edition","author":"K, Brown J.","year":"1976","unstructured":"Brown J K. Infants damaged during birth. Perinatal asphyxia. In: Gairdner D M T, ed. Recent advances in paediatrics, fifth edition. London: Churchill, 1976: 59-87."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0031-3955(16)33894-9","article-title":"Cerebral edema and neurointensive care","volume":"27","author":"F, Hahn J.","year":"1980","unstructured":"Hahn J F. Cerebral edema and neurointensive care. Pediatr Clin N Am 1980; 27: 587-92.","journal-title":"Pediatr Clin N Am"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1203\/00006450-197404000-00004","article-title":"Anoxia in mice: reduced glucose in brain with normal or elevated glucose in plasma and increased survival after glucose treatment","volume":"8","author":"Holowach-Thurston, H.; E, Hauhart R.; M, Jones E.","year":"1974","unstructured":"Holowach-Thurston H, Hauhart R E, Jones E M. Anoxia in mice: reduced glucose in brain with normal or elevated glucose in plasma and increased survival after glucose treatment. Pediatr Res 1974; 8: 238-43.","journal-title":"Pediatr Res"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/ajplegacy.1976.230.5.1269","article-title":"Carbohydrate metabolism in fetal and neonatal rat brain during anoxia and recovery","volume":"230","author":"C, Vannucci R.; E, Duffy T.","year":"1976","unstructured":"Vannucci R C, Duffy T E. Carbohydrate metabolism in fetal and neonatal rat brain during anoxia and recovery. Am J Physiol 1976; 230: 1269-75.","journal-title":"Am J Physiol"},{"key":"ref_38","first-page":"10","article-title":"Neonatal hypoglycemia revisited","volume":"58","author":"L, Gutberlat R.; M, Cornblath","year":"1975","unstructured":"Gutberlat R L, Cornblath M. Neonatal hypoglycemia revisited. Pediatrics 1975; 58: 10-7.","journal-title":"Pediatrics"},{"key":"ref_39","first-page":"85","article-title":"Lactic acid accumulation as cause of brain edema and cerebral necrosis resulting from oxygen deprivation","volume-title":"Advances in perinatal neurology","volume":"1","author":"E, Myers R.","year":"1979","unstructured":"Myers R E. Lactic acid accumulation as cause of brain edema and cerebral necrosis resulting from oxygen deprivation. In: Korobkin R, Guilleminault C, eds. Advances in perinatal neurology. Vol. 1. New York: Spectrum Publishers, 1979: 85-114."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0022-3476(80)80737-2","article-title":"Perinatal asphyxia and the myocardium","volume":"96","author":"H, Lees M.","year":"1980","unstructured":"Lees M H. Perinatal asphyxia and the myocardium. J Pediatr 1980; 96: 675-8.","journal-title":"J Pediatr"},{"key":"ref_41","first-page":"173","article-title":"The physiology of the cerebral circulation","author":"J, Purves M.","year":"1972","unstructured":"Purves M J. The physiology of the cerebral circulation. London: Cambridge University Press, 1972: 173-99."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1542\/peds.62.4.465","article-title":"Hypercarbia at birth: a possible role in the pathogenesis of intraventricular hemorrhage","volume":"62","author":"D, Kenny J.; A, Garcia-Prats J.; L, Hilliard J.; S, Corbet A.J.; J, Rudolph A.","year":"1978","unstructured":"Kenny J D, Garcia-Prats J A, Hilliard J L, Corbet A J S, Rudolph A J. Hypercarbia at birth: a possible role in the pathogenesis of intraventricular hemorrhage. Pediatrics 1978; 62: 465-7.","journal-title":"Pediatrics"},{"key":"ref_43","first-page":"317","article-title":"Positive pressure ventilation and cranial volume in newborn infants (abstract)","volume":"55","author":"A, Milligan D.W.","year":"1980","unstructured":"Milligan D W A. Positive pressure ventilation and cranial volume in newborn infants (abstract). Arch Dis Child 1980; 55: 317.","journal-title":"Arch Dis Child"},{"key":"ref_44","first-page":"467","article-title":"Effects of long term controlled ventilation in intracranial hypertension","volume":"2","author":"D, Miller J.","year":"1975","unstructured":"Miller J D. Effects of long term controlled ventilation in intracranial hypertension. In: Lundberg N, Pont6n U, Brock M, eds. Intracranial pressure. Vol. 2. Berlin: Springer, 1975: 467-70."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1651-2227.1975.tb04383.x","article-title":"Single injection polyfructosan clearance in normal and asphyxiated neonates","volume":"64","author":"W, Svenningsen N.","year":"1975","unstructured":"Svenningsen N W. Single injection polyfructosan clearance in normal and asphyxiated neonates. Acta Paediatr Scand 1975; 64: 87-95.","journal-title":"Acta Paediatr Scand"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/jcbfm.1981.34","article-title":"Brain lactic acidosis and ischaemic damage","volume":"1","author":"Rehncroma, S.; Ros6n, I.; K, Siesj6 B.","year":"1981","unstructured":"Rehncroma S, Ros6n I, Siesj6 B K. Brain lactic acidosis and ischaemic damage. J Cerebral Blood Flow Metab 1981; 1: 297-311.","journal-title":"J Cerebral Blood Flow Metab"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.57.3.176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T03:47:22Z","timestamp":1684813642000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.57.3.176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,3,1]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.57.3.176","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,3,1]]}}}