{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:24:12Z","timestamp":1758821052634},"reference-count":37,"publisher":"BMJ","issue":"4 Spec No","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1992,4,1]]},"DOI":"10.1136\/adc.67.4_spec_no.388","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T22:39:16Z","timestamp":1229985556000},"page":"388-392","source":"Crossref","is-referenced-by-count":27,"title":["Plasma hypoxanthine: a marker for hypoxic-ischaemic induced periventricular leucomalacia?"],"prefix":"10.1136","volume":"67","author":[{"given":"G A","family":"Russell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Jeffers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1136\/adc.61.12.1196","article-title":"Periventricular leucomalacia and intraventricular haemorrhage in the preterm neonate","volume":"61","author":"Trounce, J.Q.; Rutter, N.; Levene, M.I.","year":"1986","unstructured":"Trounce JQ, Rutter N, Levene MI. Periventricular leucomalacia and intraventricular haemorrhage in the preterm neonate. Arch Dis Child 1986;61:1196-202.","journal-title":"Arch Dis Child"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0378-3782(85)90099-4","article-title":"Neurodevelopmental outcome at 12 months of age related to cerebral ultrasound appearances of high risk preterm neonates","volume":"11","author":"Fawer, C.-L.; Calame, A.; Furrer, M.-T.","year":"1985","unstructured":"Fawer C-L, Calame A, Furrer M-T. Neurodevelopmental outcome at 12 months of age related to cerebral ultrasound appearances of high risk preterm neonates. Early Hum Dev 1985;11:123-32.","journal-title":"Early Hum Dev"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0140-6736(87)92986-2","article-title":"Prediction of cerebral palsy in VLBW infants: prospective ultrasound study","volume":"ii:","author":"Graham, M.; Levene, M.I.; Trounce, J.Q.","year":"1987","unstructured":"Graham M, Levene MI, Trounce JQ, et al. Prediction of cerebral palsy in VLBW infants: prospective ultrasound study. Lancet 1987;ii:593-5.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/adc.62.1.30","article-title":"PVL and neurodevelopmental outcome in preterm infants","volume":"62","author":"Fawer, C.L.; Diebold, P.; Calame, A.","year":"1987","unstructured":"Fawer CL, Diebold P, Calame A. PVL and neurodevelopmental outcome in preterm infants. Arch Dis Child 1987;62:30-6.","journal-title":"Arch Dis Child"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-8749.1987.tb02101.x","article-title":"Probability of neurodevelopmental disorders estimated for US appearance of brains of very preterm infants","volume":"29","author":"Stewart, A.L.; Reynolds, E.O.R.; Hope, P.L.","year":"1987","unstructured":"Stewart AL, Reynolds EOR, Hope PL, et al. Probability of neurodevelopmental disorders estimated for US appearance of brains of very preterm infants. Dev Med Child Neurol 1987;29:3-1 1.","journal-title":"Dev Med Child Neurol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(90)90002-Z","article-title":"White matter damage in preterm newborns-an epidemiologic perspective","volume":"24","author":"Leviton, A.; Paneth, N.","year":"1990","unstructured":"Leviton A, Paneth N. White matter damage in preterm newborns-an epidemiologic perspective. Early Hum Dev 1990;24:1-22.","journal-title":"Early Hum Dev"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1542\/peds.69.3.282","article-title":"Hemorrhagic periventricular leukomalacia: diagnosis by real time ultrasound and correlation with autopsy findings","volume":"69","author":"Hill, A.; Melson, G.L.; Clark, H.B.; Volpe, J.J.","year":"1982","unstructured":"Hill A, Melson GL, Clark HB, Volpe JJ. Hemorrhagic periventricular leukomalacia: diagnosis by real time ultrasound and correlation with autopsy findings. Pediatrics 1982;69:282-4.","journal-title":"Pediatrics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/adc.61.12.1203","article-title":"Intraventricular haemorrhage and periventricular leucomalacia: ultrasound and autopsy correlation","volume":"61","author":"Trounce, J.Q.; Fagan, D.; Levene, M.I.","year":"1986","unstructured":"Trounce JQ, Fagan D, Levene MI. Intraventricular haemorrhage and periventricular leucomalacia: ultrasound and autopsy correlation. Arch Dis Child 1986;61:1203-7.","journal-title":"Arch Dis Child"},{"key":"ref_9","first-page":"154","article-title":"Relation between periventricular haemorrhage and ischaemic brain lesions diagnosed by ultrasound in very pre-term infants","volume":"1","author":"Sinha, S.K.; Davies, J.M.; Sims, D.G.; Chiswick, M.L.","year":"1985","unstructured":"Sinha SK, Davies JM, Sims DG, Chiswick ML. Relation between periventricular haemorrhage and ischaemic brain lesions diagnosed by ultrasound in very pre-term infants. Lancet 1985;ii:1 154-5.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1469-8749.1985.tb03805.x","article-title":"Developnient of cerebral palsy after ultrasonographic detection of periventricular cysts in the newborn","volume":"27","author":"Weindling, A.M.; Rochefort, M.J.; Calvert, S.A.; Fok, T.-F.; Wilkinson, A.","year":"1985","unstructured":"Weindling AM, Rochefort MJ, Calvert SA, Fok T-F, Wilkinson A. Developnient of cerebral palsy after ultrasonographic detection of periventricular cysts in the newborn. Dev Med Child Neurol 1985;27:800-6.","journal-title":"Dev Med Child Neurol"},{"key":"ref_11","first-page":"732","article-title":"Perinatal risk factors for the development of extensive cystic leukomalacia","volume":"142","author":"LS, De Vries; R, Regev; MS, Dubowitz; A, Whitelaw; VR, Aber","year":"1988","unstructured":"De Vries LS, Regev R, Dubowitz MS, Whitelaw A, Aber VR. Perinatal risk factors for the development of extensive cystic leukomalacia. Am J Dis Child 1988;142:732-5.","journal-title":"Am J Dis Child"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/adc.63.1.17","article-title":"Clinical risk factors and periventricular leucomalacia","volume":"63","author":"Trounce, J.Q.; Shaw, D.E.; Levene, M.I.; Rutter, N.","year":"1988","unstructured":"Trounce JQ, Shaw DE, Levene MI, Rutter N. Clinical risk factors and periventricular leucomalacia. Arch Dis Child 1988;63:17-22.","journal-title":"Arch Dis Child"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1600-0404.1984.tb00843.x","article-title":"Cerebral angioarchitecture and perinatal brain lesions in premature and full-term infants","volume":"70","author":"JL, De Reuk","year":"1984","unstructured":"De Reuk JL. Cerebral angioarchitecture and perinatal brain lesions in premature and full-term infants. Acta Neurol Scand 1984;70:391-5.","journal-title":"Acta Neurol Scand"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1203\/00006450-197504000-00002","article-title":"Hypoxanthine as a measurement of hypoxia","volume":"9","author":"Saugstad, O.D.","year":"1975","unstructured":"Saugstad OD. Hypoxanthine as a measurement of hypoxia. Pediatr Res 1975;9:158-61.","journal-title":"Pediatr Res"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1203\/00006450-198802000-00001","article-title":"Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production","volume":"23","author":"Saugstad, O.D.","year":"1988","unstructured":"Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 1988;23:143-50.","journal-title":"Pediatr Res"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1651-2227.1983.tb09703.x","article-title":"Cord plasma hypoxanthine as a measure of foetal asphyxia","volume":"72","author":"Thiringer, K.","year":"1983","unstructured":"Thiringer K. Cord plasma hypoxanthine as a measure of foetal asphyxia. Acta Paediatr Scand 1983;72:231-7.","journal-title":"Acta Paediatr Scand"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1203\/00006450-198202000-00015","article-title":"Hypoxanthine concentration in plasma during the first two hours after birth in normal and asphyxiated infants","volume":"16","author":"Bratteby, L.-E.; Swanstrom, S.","year":"1982","unstructured":"Bratteby L-E, Swanstrom S. Hypoxanthine concentration in plasma during the first two hours after birth in normal and asphyxiated infants. Pediatr Res 1982;16:152-5.","journal-title":"Pediatr Res"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/jcp.35.9.999","article-title":"Intrapartum hypoxia: the association between neurological assessment of damage and abnormal excretion of ATP metabolites","volume":"35","author":"Harkness, R.A.; Whitelaw, A.G.L.; Simmonds, R.J.","year":"1982","unstructured":"Harkness RA, Whitelaw AGL, Simmonds RJ. Intrapartum hypoxia: the association between neurological assessment of damage and abnormal excretion of ATP metabolites. J Clin Pathol 1982;35:999-1007.","journal-title":"J Clin Pathol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-0404.1978.tb04501.x","article-title":"The determination of inosine and hypoxanthine in rat brain during normothermic and hypothermic anoxia","volume":"57","author":"Saugstad, O.D.; Schrader, H.","year":"1978","unstructured":"Saugstad OD, Schrader H. The determination of inosine and hypoxanthine in rat brain during normothermic and hypothermic anoxia. Acta Neurol Scand 1978;57:281-8.","journal-title":"Acta Neurol Scand"},{"key":"ref_20","first-page":"211","article-title":"Breakdown of 5'-adenine nucleotides in ischemic renal cortex estimated by oxypurine excretion during perfusion","volume":"35","author":"Buhl, M.R.; Jorgensen, S.","year":"1975","unstructured":"Buhl MR, Jorgensen S. Breakdown of 5'-adenine nucleotides in ischemic renal cortex estimated by oxypurine excretion during perfusion. ScandJa Clin Lab Invest 1975;35:211-7.","journal-title":"ScandJa Clin Lab Invest"},{"issue":"35","key":"ref_21","first-page":"109","article-title":"Adenine nucleotide metabolism of the heart","volume":"34","author":"Berne, R.M.; Rubio, R.","year":"1974","unstructured":"Berne RM, Rubio R. Adenine nucleotide metabolism of the heart. Circ Res 34\/35 (Suppl) 1974;111:109-20.","journal-title":"Circ Res"},{"key":"ref_22","first-page":"4046","article-title":"Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury","volume-title":"postischemic tissues. Proc Natl Acad Sci","volume":"85","author":"Zweier, J.L.; Kuppusamy, P.; Lutty, G.A.","year":"1988","unstructured":"Zweier JL, Kuppusamy P, Lutty GA. Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. Proc Natl Acad Sci USA 1988;85:4046-50."},{"issue":"20","key":"ref_23","first-page":"488","article-title":"Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats","volume":"1989","author":"Martz, D.; Rayos, G.; Schielke, G.P.; Betz, A.L.","unstructured":"Martz D, Rayos G, Schielke GP, Betz AL. Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats. Stroke 1989-20:488-94.","journal-title":"Stroke"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1203\/00006450-199004000-00003","article-title":"Reduction of perinatal hypoxic-ischemic brain damage with allopurinol","volume":"27","author":"Palmer, C.; Vannucci, R.C.; Towfighi, J.","year":"1990","unstructured":"Palmer C, Vannucci RC, Towfighi J. Reduction of perinatal hypoxic-ischemic brain damage with allopurinol. Pediatr Res 1990;27:332-6.","journal-title":"Pediatr Res"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1203\/00006450-199012000-00015","article-title":"Brain superoxide generation during asphyxia and reventilation in newborn pigs","volume":"28","author":"Pourcyrous, M.; Leffler, C.W.; Mirro, R.; Busija, D.W.","year":"1990","unstructured":"Pourcyrous M, Leffler CW, Mirro R, Busija DW. Brain superoxide generation during asphyxia and reventilation in newborn pigs. Pediatr Res 1990;28:618-21.","journal-title":"Pediatr Res"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-4347(00)81739-9","article-title":"Cooke chromatographic determination of hypoxanthine and xanthine in biological fluids","volume":"233","author":"Boulieu, R.; Bory, C.; liquid Russell, Baltassat P.High-performance; Jeffers","year":"1982","unstructured":"Boulieu R, Bory C, Baltassat P. High-performance liquid Russell,Jeffers, Cooke chromatographic determination of hypoxanthine and xanthine in biological fluids. J Chromatogr 1982;233: 131-40.","journal-title":"J Chromatogr"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1203\/00006450-198202000-00016","article-title":"Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH","volume":"16","author":"Swanstrom, S.; Bratteby, L.-E.","year":"1982","unstructured":"Swanstrom S, Bratteby L-E. Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit, and pH. Pediatr Res 1982;16:156-60.","journal-title":"Pediatr Res"},{"issue":"7","key":"ref_28","first-page":"386","article-title":"Periventricular leukomalacia of infancy","volume":"1962","author":"Banker, B.Q.; Larroche-J.-C.","unstructured":"Banker BQ, Larroche-J-C. Periventricular leukomalacia of infancy. Arch Neurol 1962;7:386-410.","journal-title":"Arch Neurol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0022-3476(88)80024-6","article-title":"Prediction of perinatal brain damage by cord plasma vasopressin, erythropoietin, and hypoxanthine values","volume":"113","author":"Ruth, V.; Autti-Ramo, I.; Granstrom, M.-L.; Korkman, M.; Raivio, K.O.","year":"1988","unstructured":"Ruth V, Autti-Ramo I, Granstrom M-L, Korkman M, Raivio KO. Prediction of perinatal brain damage by cord plasma vasopressin, erythropoietin, and hypoxanthine values. J Pediatr 1988;113:880-5.","journal-title":"J Pediatr"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1203\/00006450-197401000-00009","article-title":"Circulation and oxygen consumption in the fetal brain","volume":"8","year":"1974","unstructured":"Circulation and oxygen consumption in the fetal brain. Pediatr Res 1974;8:50-7.","journal-title":"Pediatr Res"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1471-4159.1988.tb03006.x","article-title":"Hypoxanthine transport and metabolism in the central nervous system","volume":"50","author":"Spector, R.","year":"1988","unstructured":"Spector R. Hypoxanthine transport and metabolism in the central nervous system. J Neurochem 1988;50:969-78.","journal-title":"J Neurochem"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000128021","article-title":"Plasma hypoxanthine levels in pigs during acute hypoxaemia: a correlation between lactate and base deficit concentrations","volume":"10","year":"1978","unstructured":"Saugstad OD, Aasen AO, Hetland 0. Plasma hypoxanthine levels in pigs during acute hypoxaemia: a correlation between lactate and base deficit concentrations. Eur Surg Res 1978;10:314-21.","journal-title":"Eur Surg Res"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0006-8993(82)90836-8","article-title":"Cerebral arterio-venous difference for hypoxanthine and lactate during graded asphyxia in the fetal lamb","volume":"239","author":"Thiringer, K.; Blomstrand, S.; Hrbek, A.; Karisson, K.; Kjellmer, I.","year":"1982","unstructured":"Thiringer K, Blomstrand S, Hrbek A, Karisson K, Kjellmer I. Cerebral arterio-venous difference for hypoxanthine and lactate during graded asphyxia in the fetal lamb. Brain Res 1982;239: 107-17.","journal-title":"Brain Res"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1651-2227.1987.tb10408.x","article-title":"Elevated levels of immunoreactive prostacyclin metabolite in babies who develop intraventricular haemorrhage","volume":"76","author":"Rennie, J.M.; Doyle, J.; Cooke, R.W.I.","year":"1987","unstructured":"Rennie JM, Doyle J, Cooke RWI. Elevated levels of immunoreactive prostacyclin metabolite in babies who develop intraventricular haemorrhage. Acta Paediair Scand 1987;76: 19-23.","journal-title":"Acta Paediair Scand"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1203\/00006450-198605000-00019","article-title":"On the pathogenesis of regional cerebral ischaemia in intracranial haemorrhage: a causal influence of potassium?","volume":"20","author":"Edvinsson, L.; Lou, H.C.; Tvede, K.","year":"1986","unstructured":"Edvinsson L, Lou HC, Tvede K. On the pathogenesis of regional cerebral ischaemia in intracranial haemorrhage: a causal influence of potassium? Pediatr Res 1986;20:478-80.","journal-title":"Pediatr Res"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/path.1711510307","article-title":"Periventricular intraparenchymal cerebral haemorrhage in preterm infants; the role of venous infarction","volume":"151","author":"Gould, S.J.; Howard, S.; Hope, P.L.; Reynolds, E.O.R.","year":"1987","unstructured":"Gould SJ, Howard S, Hope PL, Reynolds EOR. Periventricular intraparenchymal cerebral haemorrhage in preterm infants; the role of venous infarction. J Pathol 1987;151: 197-202.","journal-title":"J Pathol"},{"key":"ref_37","first-page":"47","article-title":"Ischemia-reperfusion injury: role of oxygen-derived free radicals","volume":"548","author":"Granger, D.N.; Hollwarth, M.E.; Parks, D.A.","year":"1986","unstructured":"Granger DN, Hollwarth ME, Parks DA. Ischemia-reperfusion injury: role of oxygen-derived free radicals. Acta Physiol Scand 1986;548:suppl:47-63.","journal-title":"Acta Physiol Scand"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.67.4_Spec_No.388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:39:57Z","timestamp":1709811597000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.67.4_Spec_No.388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4,1]]},"references-count":37,"journal-issue":{"issue":"4 Spec No","published-print":{"date-parts":[[1992,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.67.4_spec_no.388","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4,1]]}}}