{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:46:36Z","timestamp":1783633596234,"version":"3.55.0"},"reference-count":30,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1995,8,1]]},"DOI":"10.1136\/adc.73.2.141","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T23:07:28Z","timestamp":1229987248000},"page":"141-146","source":"Crossref","is-referenced-by-count":62,"title":["Growth and puberty after growth hormone treatment after irradiation for brain tumours."],"prefix":"10.1136","volume":"73","author":[{"given":"A L","family":"Ogilvy-Stuart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Shalet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/adc.53.6.491","article-title":"Growth impairment in children treated for brain tumours","volume":"53","author":"Shalet, S.M.; Beardwell, C.G.; Aarons, B.M.; Pearson, D.; Morris Jones, P.H.","year":"1978","unstructured":"Shalet SM, Beardwell CG, Aarons BM, Pearson D, Morris Jones PH. Growth impairment in children treated for brain tumours. Arch Dis Child 1978; 53: 491-4.","journal-title":"Arch Dis Child"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/adc.58.9.722","article-title":"Growth and endocrine function after treatment for medulloblastoma","volume":"58","author":"Brown, I.H.; Lee, T.J.; Eden, O.B.; Bullimore, J.A.; Savage, D.C.L.","year":"1983","unstructured":"Brown IH, Lee TJ, Eden OB, Bullimore JA, Savage DCL. Growth and endocrine function after treatment for medulloblastoma. Arch Dis Child 1983; 58: 722-7.","journal-title":"Arch Dis Child"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0022-3476(76)80385-X","article-title":"Delayed onset of hypopituitarism: sequelae of therapeutic irradiation of central nervous system, eye, and middle ear tumors","volume":"89","author":"Richards, G.E.; Wara, W.M.; Grumbach, M.M.; Kaplan, S.I.; Sheline, G.E.; Conte, F.A.","year":"1976","unstructured":"Richards GE, Wara WM, Grumbach MM, Kaplan SI, Sheline GE, Conte FA. Delayed onset of hypopituitarism: sequelae of therapeutic irradiation of central nervous system, eye, and middle ear tumors. J Pediatr 1976; 89: 553-9.","journal-title":"J Pediatr"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2265.1976.tb01965.x","article-title":"Hypothalamic hypopituitarism following external radiotherapy for tumours distant from the adenohypophysis","volume":"5","author":"Perry-Keene, D.A.; Connelly, J.F.; Young, R.A.; Wettenhall, H.N.B.; Martin, F.I.R.","year":"1976","unstructured":"Perry-Keene DA, Connelly JF, Young RA, Wettenhall HNB, Martin FIR. Hypothalamic hypopituitarism following external radiotherapy for tumours distant from the adenohypophysis. Clin Endocrinol (Oxf) 1976; 5: 373-80.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1651-2227.1981.tb07177.x","article-title":"The effects of growth hormone therapy in children with radiation-induced growth hormone deficiency","volume":"70","author":"Shalet, S.M.; Whitehead, E.; Chapman, A.J.; Beardwell, C.G.","year":"1981","unstructured":"Shalet SM, Whitehead E, Chapman AJ, Beardwell CG. The effects of growth hormone therapy in children with radiation-induced growth hormone deficiency. Acta Paediatr Scand 1981; 70: 81-6.","journal-title":"Acta Paediatr Scand"},{"key":"ref_6","first-page":"593","article-title":"Growth response to growth hormone therapy following cranial irradiation","volume-title":"EurJ7Pediatr","volume":"147","author":"Clayton, P.E.; Shalet, S.M.; Price, D.A.","year":"1988","unstructured":"Clayton PE, Shalet SM, Price DA. Growth response to growth hormone therapy following cranial irradiation. EurJ7Pediatr 1988; 147: 593-6."},{"key":"ref_7","first-page":"597","article-title":"Growth response to growth hormone therapy following craniospinal irradiation","volume":"147","author":"Clayton, P.E.; Shalet, S.M.; Price, D.A.","year":"1988","unstructured":"Clayton PE, Shalet SM, Price DA. Growth response to growth hormone therapy following craniospinal irradiation. EurJPediatr 1988; 147: 597-601.","journal-title":"EurJPediatr"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1651-2227.1990.tb11509.x","article-title":"Response to growth hormone treatment and final height after cranial or craniospinal irradiation","volume":"79","author":"Sulmont, V.; Brauner, R.; Fontoura, M.; Rappaport, R.","year":"1990","unstructured":"Sulmont V, Brauner R, Fontoura M, Rappaport R. Response to growth hormone treatment and final height after cranial or craniospinal irradiation. Acta Paediatr Scand 1990; 79: 542-9.","journal-title":"Acta Paediatr Scand"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1651-2227.1990.tb11357.x","article-title":"Growth and growth hormone secretion in children following treatment of brain tumours with radiotherapy","volume":"79","author":"Darendeliler, F.; Livesey, E.A.; Hindmarsh, P.C.; Brook, C.G.D.","year":"1990","unstructured":"Darendeliler F, Livesey EA, Hindmarsh PC, Brook CGD. Growth and growth hormone secretion in children following treatment of brain tumours with radiotherapy. Acta Paediatr Scand 1990; 79: 950-6.","journal-title":"Acta Paediatr Scand"},{"key":"ref_10","first-page":"1282","article-title":"Cranial irradiation and early puberty","volume":"78","author":"Ogilvy-Stuart, A.L.; Clayton, P.E.; Shalet, S.M.","year":"1994","unstructured":"Ogilvy-Stuart AL, Clayton PE, Shalet SM. Cranial irradiation and early puberty. Jf Clin Endocrinol Metab 1994; 78: 1282-6.","journal-title":"Jf Clin Endocrinol Metab"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1530\/acta.0.1220414","article-title":"Growth hormone increases rate of pubertal maturation","volume":"122","author":"Darendeliler, F.; Hindmarsh, P.C.; Preece, M.A.; Cox, L.; Brook, C.G.D.","year":"1990","unstructured":"Darendeliler F, Hindmarsh PC, Preece MA, Cox L, Brook CGD. Growth hormone increases rate of pubertal maturation. Acta Endocrinol (Copenh) 1990; 122: 414-6.","journal-title":"Acta Endocrinol (Copenh)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/1097-0142(19921001)70:7<2013::AID-CNCR2820700734>3.0.CO;2-J","article-title":"The effects of adjuvant chemotherapy on growth in children with medulloblastoma","volume":"70","author":"Olshan, J.S.; Gubernick, J.; Packer, R.J.","year":"1992","unstructured":"Olshan JS, Gubernick J, Packer RJ, et al. The effects of adjuvant chemotherapy on growth in children with medulloblastoma. Cancer 1992; 70: 2013-7.","journal-title":"Cancer"},{"issue":"44","key":"ref_13","first-page":"291","article-title":"Variations in the pattern of pubertal changes in girls","volume":"1969","author":"Marshall, W.A.; Tanner, J.M.","unstructured":"Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291-303.","journal-title":"Arch Dis Child"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","author":"Marshall, W.A.; Tanner, J.M.","year":"1970","unstructured":"Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13-23.","journal-title":"Arch Dis Child"},{"key":"ref_15","first-page":"61","article-title":"Testicular volumes during adolescence. Cross sectional and longitudinal studies","volume":"29","author":"Zachmann, M.; Prader, A.; Kind, H.P.; Haflinger, H.; Budlinger, H.","year":"1974","unstructured":"Zachmann M, Prader A, Kind HP, Haflinger H, Budlinger H. Testicular volumes during adolescence. Cross sectional and longitudinal studies. Helvetica Pediatrica Acta 1974; 29: 61-72.","journal-title":"Helvetica Pediatrica Acta"},{"key":"ref_16","article-title":"Assessment of skeletal maturity and prediction of adult height (TW2 method)","author":"Tanner, J.M.; Whitehouse, R.H.; Cameron, N.; Marshall, W.A.; Healy, M.J.R.; Goldstein, H.","year":"1983","unstructured":"Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healy MJR, Goldstein H. Assessment of skeletal maturity and prediction of adult height (TW2 method). London: Academic Press, 1983."},{"key":"ref_17","article-title":"Standards for standing height and subischial leg length from birth to maturity: British children 1978","author":"Tanner, J.M.; Whitehouse, R.H.","year":"1979","unstructured":"Tanner JM, Whitehouse RH. Standards for standing height and subischial leg length from birth to maturity: British children 1978. Hertford: Castlemead Publications, 1979."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-3476(84)80988-9","article-title":"Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature","volume":"104","author":"Romshe, C.A.; Zipf, W.B.; Miser, A.; Miser, J.; Sotos, J.F.; Newton, W.A.","year":"1984","unstructured":"Romshe CA, Zipf WB, Miser A, Miser J, Sotos JF, Newton WA. Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature. JPediatr 1984; 104: 177-81.","journal-title":"JPediatr"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0022-3476(85)80083-4","article-title":"Irradiation-induced growth hormone deficiency: blunted growth response and accelerated skeletal maturation to growth hormone therapy","volume":"106","author":"Winter, R.J.; Green, O.C.","year":"1985","unstructured":"Winter RJ, Green OC. Irradiation-induced growth hormone deficiency: blunted growth response and accelerated skeletal maturation to growth hormone therapy. Jf Pediatr 1985; 106: 609-12.","journal-title":"Jf Pediatr"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1651-2227.1989.tb17937.x","article-title":"Improved growth response to GH treatment in irradiated children","volume":"78","author":"Lannering, B.; Albertsson-Wikland, K.","year":"1989","unstructured":"Lannering B, Albertsson-Wikland K. Improved growth response to GH treatment in irradiated children. Acta Paediatr Scand 1989; 78: 562-7.","journal-title":"Acta Paediatr Scand"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000180073","article-title":"Final stature in brain tumours other than craniopharyngioma: effect of growth hormone","volume":"22","author":"Herber, S.M.; Dunsmore, I.R.; Milner, R.D.G.","year":"1985","unstructured":"Herber SM, Dunsmore IR, Milner RDG. Final stature in brain tumours other than craniopharyngioma: effect of growth hormone. Horm Res 1985; 22: 63-7.","journal-title":"Horm Res"},{"key":"ref_22","article-title":"In vitro effects of anti-leukaemic drugs on cartilage metabolism and their effects on somatomedin production by the liver","author":"Morris, M.J.","year":"1981","unstructured":"Morris MJ. In vitro effects of anti-leukaemic drugs on cartilage metabolism and their effects on somatomedin production by the liver. Manchester: University of Manchester, 1981. (PhD thesis.)"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/mpo.2950200218","article-title":"Chemotherapy with actinomycin D influences the growth of the spine following abdominal irradiation","volume":"20","author":"Wallace, W.H.B.; Shalet, S.M.","year":"1992","unstructured":"Wallace WHB, Shalet SM. Chemotherapy with actinomycin D influences the growth of the spine following abdominal irradiation [Letter]. Med Pediatr Oncol 1992; 20: 177.","journal-title":"Med Pediatr Oncol"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJM199008093230604","article-title":"Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood","volume":"323","author":"O'Driscoll, B.R.; Hasleton, P.S.; Taylor, P.M.; Poulter, L.W.; Gattamaneni, H.R.; Woodcock, A.A.","year":"1990","unstructured":"O'Driscoll BR, Hasleton PS, Taylor PM, Poulter LW, Gattamaneni HR, Woodcock AA. Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood. N EnglJMed 1990; 323: 378-82.","journal-title":"N EnglJMed"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1097-0142(197309)32:3<634::AID-CNCR2820320316>3.0.CO;2-A","article-title":"Growth retardation in children after megavoltage irradiation of the spine","volume":"32","author":"Probert, J.C.; Parker, B.R.; Kaplan, H.S.","year":"1973","unstructured":"Probert JC, Parker BR, Kaplan HS. Growth retardation in children after megavoltage irradiation of the spine. Cancer 1973; 32: 634-9.","journal-title":"Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/adc.62.5.461","article-title":"Effect of spinal irradiation on growth","volume":"62","author":"Shalet, S.M.; Gibson, B.; Swindell, R.; Pearson, D.","year":"1987","unstructured":"Shalet SM, Gibson B, Swindell R, Pearson D. Effect of spinal irradiation on growth. Arch Dis Child 1987; 62: 461-4.","journal-title":"Arch Dis Child"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0936-6555(05)80744-7","article-title":"The evolution of spinal growth after irradiation","volume":"3","author":"Clayton, P.E.; Shalet, S.M.","year":"1991","unstructured":"Clayton PE, Shalet SM. The evolution of spinal growth after irradiation. Clin Oncol 1991; 3: 220-2.","journal-title":"Clin Oncol"},{"key":"ref_28","first-page":"117","article-title":"The effect on growth of increased hGH dosage following cranial (CR) or craniospinal (CS) irradiation","volume":"35","author":"Sauvion, S.; Brauner, R.; Sulmont, V.; Rappaport, R.","year":"1991","unstructured":"Sauvion S, Brauner R, Sulmont V, Rappaport R. The effect on growth of increased hGH dosage following cranial (CR) or craniospinal (CS) irradiation. Horm Res 1991; 35 (suppl): 117.","journal-title":"Horm Res"},{"key":"ref_29","first-page":"257","article-title":"Lack of mitogenic effects of growth hormone on human leukemic lymphoblasts","volume":"146","author":"Blatt, J.; Wenger, S.; Stitely, S.; Lee, P.A.","year":"1987","unstructured":"Blatt J, Wenger S, Stitely S, Lee PA. Lack of mitogenic effects of growth hormone on human leukemic lymphoblasts. EurJPediatr 1987; 146: 257-60.","journal-title":"EurJPediatr"},{"issue":"347","key":"ref_30","first-page":"16","article-title":"Variations in duration of pubertal growth: a mechanism compensating for differences in timing of puberty and minimizing their effects on final height","volume":"1988","author":"Bourguignon, J.P.","unstructured":"Bourguignon JP. Variations in duration of pubertal growth: a mechanism compensating for differences in timing of puberty and minimizing their effects on final height. Acta Paediatr Scand 1988; 347 (suppl): 16-24.","journal-title":"Acta Paediatr Scand"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.73.2.141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T21:47:12Z","timestamp":1601070432000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.73.2.141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8,1]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.73.2.141","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8,1]]}}}