{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:14:45Z","timestamp":1781849685992,"version":"3.54.5"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1995,9,1]]},"DOI":"10.1136\/adc.73.3.189","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T23:07:28Z","timestamp":1229987248000},"page":"189-191","source":"Crossref","is-referenced-by-count":9,"title":["Molecular biology of coeliac disease."],"prefix":"10.1136","volume":"73","author":[{"given":"R","family":"Tighe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Ciclitira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"17","article-title":"On the coeliac affection. St Bartholomews Hospital Report 1888; 24","author":"Gee, S.","unstructured":"Gee S. On the coeliac affection. St Bartholomews Hospital Report 1888; 24: 17-20."},{"key":"ref_2","article-title":"Coeliake","author":"Dicke, W.K.","year":"1950","unstructured":"Dicke WK. Coeliake. Utrecht: University of Utrecht, 1950. (MD thesis.)"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1084\/jem.160.5.1544","article-title":"Possible role of a human adenovirus in the pathogenesis of coeliac disease","volume":"160","author":"Kagnoff, M.R.; Raleigh, K.A.; Hubert, J.J.; Bernadin, J.F.; Kasarda, D.D.","year":"1984","unstructured":"Kagnoff MR, Raleigh KA, Hubert JJ, Bernadin JF, Kasarda DD. Possible role of a human adenovirus in the pathogenesis of coeliac disease. Jf Exp Med 1984; 160: 1544-7.","journal-title":"Jf Exp Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/gut.31.6.668","article-title":"Cellular hypersensitivity to a synthetic dodecapeptide derived from human adenovirus 12 which resembles a sequence of A-gliadin in patients with coeliac disease","volume":"31","author":"Mantzaris, G.J.; Karagiannis, J.A.; Priddle, J.D.; Jewell, D.P.","year":"1990","unstructured":"Mantzaris GJ, Karagiannis JA, Priddle JD, Jewell DP. Cellular hypersensitivity to a synthetic dodecapeptide derived from human adenovirus 12 which resembles a sequence of A-gliadin in patients with coeliac disease. Gut 1990; 31: 668-73.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3109\/00365529108996500","article-title":"In vivo toxicity of a synthetic dodecapeptide from A gliadin in patients with coeliac disease","volume":"26","author":"Mantzaris, G.; Jewell, D.P.","year":"1991","unstructured":"Mantzaris G, Jewell DP. In vivo toxicity of a synthetic dodecapeptide from A gliadin in patients with coeliac disease. Scand J Gastroenterol 1991; 26: 392-8.","journal-title":"Scand J Gastroenterol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1136\/gut.33.11.1504","article-title":"Coeliac disease: characterisation of monoclonal antibodies raised against a synthetic peptide corresponding to amino acid residues 206-217 of A-gliadin","volume":"33","author":"Ellis, H.; Doyle, A.; Sturgess, R.; Ciclitira, P.","year":"1992","unstructured":"Ellis H, Doyle A, Sturgess R, Ciclitira P. Coeliac disease: characterisation of monoclonal antibodies raised against a synthetic peptide corresponding to amino acid residues 206-217 of A-gliadin. Gut 1992; 33: 1504-7.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1084\/jem.178.1.187","article-title":"HLA- DQ(a l*0501,,13*0201) restricted T cells isolated from the small intestinal mucosa of coeliac disease patients","volume":"178","author":"Lundin, K.E.A.; Scott, H.; Hansen, T.","year":"1993","unstructured":"Lundin KEA, Scott H, Hansen T, et al. Gliadin-specific, HLA- DQ(a l*0501,,13*0201) restricted T cells isolated from the small intestinal mucosa of coeliac disease patients. Jf Exp Med 1993; 178: 187-96.","journal-title":"Jf Exp Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0198-8859(94)90267-4","article-title":"T cells recognise a peptide derived from ca-gliadin presented by the coeliac disease-associated HLA-DQ (al*0501,, B1*0201) heterodimer","volume":"39","author":"Gjertsen, H.A.; Lundin, K.E.A.; Sollid, L.M.; Erikson, J.A.; Thorsby, E.","year":"1994","unstructured":"Gjertsen HA, Lundin KEA, Sollid LM, Erikson JA, Thorsby E. T cells recognise a peptide derived from ca-gliadin presented by the coeliac disease-associated HLA-DQ (al*0501,,B1*0201) heterodimer. Hum Immunol 1994; 39: 243-52.","journal-title":"Hum Immunol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3109\/00365529309096074","article-title":"Specificities of monoclonal antibodies to domain 1 of o-gliadins","volume":"28","author":"Ellis, H.J.; Doyle, A.P.; Wieser, H.; Sturgess, R.P.; Ciclitira, P.J.","year":"1993","unstructured":"Ellis HJ, Doyle AP, Wieser H, Sturgess RP, Ciclitira PJ. Specificities of monoclonal antibodies to domain 1 of o-gliadins. Scand Jf Gastroenterol 1993; 28: 212-6.","journal-title":"Scand Jf Gastroenterol"},{"key":"ref_10","article-title":"In vitro toxicity of gluten peptides in coeliac disease assessed by organ culture","author":"Shidrawi, R.; Day, P.; Przemioslo, R.; Ellis, H.; Nelufer, J.; Ciclitira, P.","year":"1995","unstructured":"Shidrawi R, Day P, Przemioslo R, Ellis H, Nelufer J, Ciclitira P. In vitro toxicity of gluten peptides in coeliac disease assessed by organ culture. ScandJ Gastroenterol 1995 (in press).","journal-title":"ScandJ Gastroenterol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0140-6736(94)91837-6","article-title":"Wheat challenge in coeliac disease","volume":"343","author":"Sturgess, R.; Day, P.; Ellis, H.","year":"1994","unstructured":"Sturgess R, Day P, Ellis H, et al. Wheat challenge in coeliac disease. Lancet 1994; 343: 758-61.","journal-title":"Lancet"},{"key":"ref_12","first-page":"664","article-title":"Activation of mucosal Vbeta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen Staphylococcus aureus enterotoxin B","volume":"23","author":"Lionetti, P.; Spencer, J.; Breese, E.J.; Murch, S.H.; Taylor, J.W.; MacDonald, T.T.","year":"1993","unstructured":"Lionetti P, Spencer J, Breese EJ, Murch SH, Taylor JW, MacDonald TT. Activation of mucosal Vbeta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen Staphylococcus aureus enterotoxin B. EurJlmmunol 1993; 23: 664-8.","journal-title":"EurJlmmunol"},{"key":"ref_13","first-page":"459","article-title":"Phenotypical and functional characterization of small intestinal TcR gamma delta + T cells in coeliac disease","volume":"35","author":"Rust, C.; Kooy, Y.; Pena, S.; Mearin, M.L.; Kluin, P.; Koning, F.","year":"1992","unstructured":"Rust C, Kooy Y, Pena S, Mearin ML, Kluin P, Koning F. Phenotypical and functional characterization of small intestinal TcR gamma delta + T cells in coeliac disease. ScandJImmunol 1992; 35: 459-68.","journal-title":"ScandJImmunol"},{"key":"ref_14","first-page":"109","article-title":"Gamma\/delta T cells and the diagnosis of coeliac disease. Clin Exp Immunol","volume":"85","author":"Spencer, J.; Isaacson, P.G.; MacDonald, T.T.; Thomas, A.J.; Walker-Smith, J.A.","year":"1991","unstructured":"Spencer J, Isaacson PG, MacDonald TT, Thomas AJ, Walker-Smith JA. Gamma\/delta T cells and the diagnosis of coeliac disease. Clin Exp Immunol 1991; 85: 109-13."},{"key":"ref_15","series-title":"J Exp Med; cells provide B cell help","first-page":"695","article-title":"Immunoregulatory functions for murine intraepithelial lymphocytes: -y\/b T cells receptor-positive (TCR+) T cells abrogate oral tolerance, while o\/13","volume":"175","author":"Fujihashi, K.; Taguchi, T.; Aicher, W.","year":"1992","unstructured":"Fujihashi K, Taguchi T, Aicher W, et al. Immunoregulatory functions for murine intraepithelial lymphocytes: -y\/b T cells receptor-positive (TCR+) T cells abrogate oral tolerance, while o\/13 T TCR+ T cells provide B cell help.J Exp Med 1992; 175: 695-707."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.169.1.345","article-title":"Evidence for a primary association of coeliac disease to a particular HLA-DQ a113 heterodimer","volume":"169","author":"Sollid, L.; Markussen, G.; Ek, J.; Gjerde, H.; Vartdal, F.; Thorsby, E.","year":"1989","unstructured":"Sollid L, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E. Evidence for a primary association of coeliac disease to a particular HLA-DQ a113 heterodimer. J Exp Med 1989; 169: 345-50.","journal-title":"J Exp Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1399-0039.1992.tb01911.x","article-title":"A high frequency of the A30, B18, DR3, DRw52, DQw2 extended haplotype in Sardinian celiac patients: further evidence that disease susceptibility is conferred by DQA1*0501, B 1 *0201","volume":"39","author":"Coniga, M.; Frau, F.; Lampis, R.","year":"1992","unstructured":"Coniga M, Frau F, Lampis R, et al. A high frequency of the A30, B18, DR3, DRw52, DQw2 extended haplotype in Sardinian celiac patients: further evidence that disease susceptibility is conferred by DQA1*0501, B 1 *0201. Tissue Antigens 1992; 39: 78-83.","journal-title":"Tissue Antigens"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1399-0039.1992.tb01965.x","article-title":"HLA class II alleles associated with coeliac disease susceptibility in a southern European population","volume":"40","author":"Tighe, M.R.; Hall, M.A.; Barbado, M.; Cardi, E.; Welsh, K.I.; Ciclitira, P.J.","year":"1992","unstructured":"Tighe MR, Hall MA, Barbado M, Cardi E, Welsh KI, Ciclitira PJ. HLA class II alleles associated with coeliac disease susceptibility in a southern European population. Tissue Antigens 1992; 40: 90-7.","journal-title":"Tissue Antigens"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-3083.1994.tb03414.x","article-title":"T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules","volume":"39","author":"Gjertsen, H.A.; Sollid, L.M.; Ek, J.; Thorsby, E.; Lundin, K.E.","year":"1994","unstructured":"Gjertsen HA, Sollid LM, Ek J, Thorsby E, Lundin KE. T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules. Scand J Immunol 1994; 39: 567-74.","journal-title":"Scand J Immunol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/364033a0","article-title":"Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1","volume":"364","author":"Brown, J.H.; Jardensky, T.S.; Gorga, J.C.","year":"1993","unstructured":"Brown JH, Jardensky TS, Gorga JC, et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993; 364: 33-9.","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0198-8859(93)90554-E","article-title":"Coeliac disease among Ashkenazi Jews from Israel: a study of the HLA class II alleles and their associations with disease susceptibility","volume":"38","author":"Tighe, M.R.; Hall, M.; Ashkenazi, A.; Siegler, E.; Lanchbury, J.; Ciclitira, P.J.","year":"1993","unstructured":"Tighe MR, Hall M, Ashkenazi A, Siegler E, Lanchbury J, Ciclitira PJ. Coeliac disease among Ashkenazi Jews from Israel: a study of the HLA class II alleles and their associations with disease susceptibility. Hum Immunol 1993; 38: 270-6.","journal-title":"Hum Immunol"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.73.3.189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T21:47:25Z","timestamp":1601070445000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.73.3.189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9,1]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.73.3.189","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9,1]]}}}