{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:16:09Z","timestamp":1791998169843,"version":"4.4.0"},"reference-count":29,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1996,1,1]]},"DOI":"10.1136\/adc.74.1.5","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T23:07:28Z","timestamp":1229987248000},"page":"5-7","source":"Crossref","is-referenced-by-count":20,"title":["Hirschprung's disease."],"prefix":"10.1136","volume":"74","author":[{"given":"P B","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0022-3468(91)90714-5","article-title":"Familial Hirschprung's disease: report of autosomal dominant and probable recessive X-linked kindreds","volume":"26","author":"Stannard, V.A.; Fowler, C.; Robinson, L.","year":"1991","unstructured":"Stannard VA, Fowler C, Robinson L, et al. Familial Hirschprung's disease: report of autosomal dominant and probable recessive X-linked kindreds. J Pediatr Surg 1991; 26: 591-4.","journal-title":"J Pediatr Surg"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/S0022-3468(05)80314-8","article-title":"Familial Hirschprung's disease: 20 cases in 12 kindreds","volume":"28","author":"Engum, S.A.; Petrites, M.; Rescorla, F.J.; Grosfeld, J.L.; Morrison, A.M.; Engles, D.","year":"1993","unstructured":"Engum SA, Petrites M, Rescorla FJ, Grosfeld JL, Morrison AM, Engles D. Familial Hirschprung's disease: 20 cases in 12 kindreds. J Pediatr Surg 1993; 28: 1286-90.","journal-title":"J Pediatr Surg"},{"key":"ref_3","first-page":"231","article-title":"Familial occurrence of Hirschprung's disease","volume":"45","author":"Russell, M.B.; Russell, C.A.; Fenger, K.; Niebuhr, E.","year":"1994","unstructured":"Russell MB, Russell CA, Fenger K, Niebuhr E. Familial occurrence of Hirschprung's disease. Clin Genet 1994; 45: 231-5.","journal-title":"Clin Genet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ng0893-351","article-title":"A gene for Hirschprung disease (megacolon) in the pericentromeric region of human chromosome 10","volume":"4","author":"Angrist, M.; Kauffman, E.; Slaugenhaupt, S.A.","year":"1993","unstructured":"Angrist M, Kauffman E, Slaugenhaupt SA, et al. A gene for Hirschprung disease (megacolon) in the pericentromeric region of human chromosome 10. Nature Genetics 1993; 4: 351-6.","journal-title":"Nature Genetics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/ng0893-346","article-title":"A gene for Hirschprung disease maps to the proximal long arm of chromosome 10","volume":"4","author":"Lyonnet, S.; Bolino, A.; Pelet, A.","year":"1993","unstructured":"Lyonnet S, Bolino A, Pelet A, et al. A gene for Hirschprung disease maps to the proximal long arm of chromosome 10. Nature Genetics 1993; 4: 346-50.","journal-title":"Nature Genetics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/jmg.31.8.602","article-title":"Long segment and short segment familial Hirschprung's disease: variable clinical expression at the RET locus","volume":"31","author":"Edery, P.; Pelet, A.; Mulligan, L.M.","year":"1994","unstructured":"Edery P, Pelet A, Mulligan LM, et al. Long segment and short segment familial Hirschprung's disease: variable clinical expression at the RET locus. JMed Genet 1994; 31: 602-6.","journal-title":"JMed Genet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/367378a0","article-title":"Mutations of the RET proto-oncogene in Hirschprung's disease","volume":"367","author":"Edery, P.; Lyonnet, S.; Mulligan, L.M.","year":"1994","unstructured":"Edery P, Lyonnet S, Mulligan LM, et al. Mutations of the RET proto-oncogene in Hirschprung's disease. Nature 1994; 367: 378-80.","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/367377a0","article-title":"Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschprung's disease","volume":"367","author":"Romeo, G.; Ronchetto, P.; Luo, Y.","year":"1994","unstructured":"Romeo G, Ronchetto P, Luo Y, et al. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschprung's disease. Nature 1994; 367: 377-8.","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0092-8674(94)90016-7","article-title":"A missense mutation of the endothelin-B receptor gene in multigenic Hirschprung's disease","volume":"79","author":"Puffenberger, E.G.; Hosoda, K.; Washington, S.S.","year":"1994","unstructured":"Puffenberger EG, Hosoda K, Washington SS, et al. A missense mutation of the endothelin-B receptor gene in multigenic Hirschprung's disease. Cell 1994; 79: 1257-66.","journal-title":"Cell"},{"key":"ref_10","first-page":"1901","article-title":"Development profile of neuron-specific enolase in human gut and its implications","volume-title":"Hirschprung's disease. Gastroenterology 1986; 90","author":"Tam, P.K.; Lister, J.","unstructured":"Tam PK, Lister J. Development profile of neuron-specific enolase in human gut and its implications in Hirschprung's disease. Gastroenterology 1986; 90: 1901-6."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/neu.480240207","article-title":"From neural crest to bowel: development of the enteric nervous system","volume":"24","author":"Gershon, M.D.; Chalazonitis, A.; Rothman, T.P.","year":"1993","unstructured":"Gershon MD, Chalazonitis A, Rothman TP. From neural crest to bowel: development of the enteric nervous system. Jf Neurobiol 1993; 24: 199-214.","journal-title":"Jf Neurobiol"},{"key":"ref_12","first-page":"83","article-title":"Contemporary approaches toward understanding the pathogenesis of Hirschprung disease [published erratum appears in Pediatr","volume":"13","author":"Kapur, R.P.","year":"1993","unstructured":"Kapur RP. Contemporary approaches toward understanding the pathogenesis of Hirschprung disease [published erratum appears in Pediatr Pathol 1993 Mar-Apr; 13 (2): following 270]. Pediatr Pathol 1993; 13: 83-100.","journal-title":"Pathol"},{"key":"ref_13","first-page":"550","article-title":"A study of the extracellular matrix protein as the migration pathway of neural crest cells in the gut: analysis in human embryos with special reference to the pathogenesis of Hirschprung's disease. J7 Pediatr Surg","volume":"24","author":"Fujimoto, T.; Hata, J.; Yokoyama, S.; Mitomi, T.","year":"1989","unstructured":"Fujimoto T, Hata J, Yokoyama S, Mitomi T. A study of the extracellular matrix protein as the migration pathway of neural crest cells in the gut: analysis in human embryos with special reference to the pathogenesis of Hirschprung's disease. J7 Pediatr Surg 1989; 24: 550-6."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cne.902550309","article-title":"Inability of neural crest cells to colonize the presumptive aganglionic bowel of ls\/ls mutant mice: requirement for a permissive microenvironment","volume":"255","author":"Jacobs-Cohen, R.J.; Payette, R.F.; Gershon, M.D.; Rothman, T.P.","year":"1987","unstructured":"Jacobs-Cohen RJ, Payette RF, Gershon MD, Rothman TP. Inability of neural crest cells to colonize the presumptive aganglionic bowel of ls\/ls mutant mice: requirement for a permissive microenvironment. Jf Comp Neurol 1987; 255: 425-38.","journal-title":"Jf Comp Neurol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1242\/dev.117.3.993","article-title":"Aggregation chimeras demonstrate that the primary defect responsible for aganglionic megacolon in lethal spotted mice is not neuroblast autonomous","volume":"117","author":"Kapur, R.P.; Yost, C.; Palmiter, R.D.","year":"1993","unstructured":"Kapur RP, Yost C, Palmiter RD. Aggregation chimeras demonstrate that the primary defect responsible for aganglionic megacolon in lethal spotted mice is not neuroblast autonomous. Development 1993; 117: 993-9.","journal-title":"Development"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0012-1606(88)90217-5","article-title":"Accumulation of components of basal laminae: association with the failure of neural crest cells to colonize the presumptive aganglionic bowel of ls\/ls mutant mice","volume":"125","year":"1988","unstructured":"Payette RF, Tennyson VM, Pomeranz HD, Pham TD, Rothman TP, Gershon MD. Accumulation of components of basal laminae: association with the failure of neural crest cells to colonize the presumptive aganglionic bowel of ls\/ls mutant mice. Dev Biol 1988; 125: 341-60.","journal-title":"Dev Biol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0022-3468(92)90545-I","article-title":"Quantitative and qualitative analysis of the extracellular matrix protein, laminin, in Hirschprung's disease","volume":"27","author":"Parikh, D.H.; Tam, P.K.; Lloyd, D.A.; van Velzen, D.; Edgar, D.H.","year":"1992","unstructured":"Parikh DH, Tam PK, Lloyd DA, van Velzen D, Edgar DH. Quantitative and qualitative analysis of the extracellular matrix protein, laminin, in Hirschprung's disease. JPediatr Surg 1992; 27: 991-6.","journal-title":"JPediatr Surg"},{"key":"ref_18","first-page":"803","article-title":"Involvement of nitric oxide in nerve-mediated inhibition and action of vasoactive intestinal peptide in colonic smooth muscle","volume":"260","author":"Huizinga, J.D.; Tomlinson, J.; Pintin-Quezada, J.","year":"1992","unstructured":"Huizinga JD, Tomlinson J, Pintin-Quezada J. Involvement of nitric oxide in nerve-mediated inhibition and action of vasoactive intestinal peptide in colonic smooth muscle. J Pharmacol Exp Ther 1992; 260: 803-8.","journal-title":"J Pharmacol Exp Ther"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0016-5085(93)90938-9","article-title":"Nitric oxide synthase distribution in the enteric nervous system of Hirschprung's disease","volume":"105","author":"Vanderwinden, J.M.; De Laet, M.H.; Schiffmann, S.N.","year":"1993","unstructured":"Vanderwinden JM, De Laet MH, Schiffmann SN, et al. Nitric oxide synthase distribution in the enteric nervous system of Hirschprung's disease. Gastroenterology 1993; 105: 969-73.","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0022-3468(94)90335-2","article-title":"Abnormalities of nitric-oxide-producing neurons in Hirschprung's disease: morphology and implications","volume":"29","author":"O'Kelly, T.J.; Davies, JR, Tam; PK, Brading; AF, Mortensen; N.J.","year":"1994","unstructured":"O'Kelly TJ, Davies JR, Tam PK, Brading AF, Mortensen NJ. Abnormalities of nitric-oxide-producing neurons in Hirschprung's disease: morphology and implications. J Pediatr Surg 1994; 29: 294-300.","journal-title":"J Pediatr Surg"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00005176-199501000-00009","article-title":"Lack of neuronal nitric oxide synthase in nerve fibers of aganglionic intestine: a clue to Hirschprung's disease","volume":"20","author":"Larsson, L.T.; Shen, Z.; Ekblad, E.; Sundler, F.; Alm, P.; Andersson, K.E.","year":"1995","unstructured":"Larsson LT, Shen Z, Ekblad E, Sundler F, Alm P, Andersson KE. Lack of neuronal nitric oxide synthase in nerve fibers of aganglionic intestine: a clue to Hirschprung's disease. Y Pediatr Gastroenterol Nutr 1995; 20: 49-53.","journal-title":"Y Pediatr Gastroenterol Nutr"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0022-3468(94)90272-0","article-title":"Effect of nitric oxide on the colonic smooth muscle of patients with Hirschprung's disease","volume":"29","author":"Bealer, J.F.; Natuzzi, E.S.; Flake, A.W.; Adzick, N.S.; Harrison, M.R.","year":"1994","unstructured":"Bealer JF, Natuzzi ES, Flake AW, Adzick NS, Harrison MR. Effect of nitric oxide on the colonic smooth muscle of patients with Hirschprung's disease. 7 Pediatr Surg 1994; 29: 1025-9.","journal-title":"7 Pediatr Surg"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0016-5085(82)80062-0","article-title":"Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation","volume":"83","author":"Gelfond, M.; Rozen, P.; Gilat, T.","year":"1982","unstructured":"Gelfond M, Rozen P, Gilat T. Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation. Gastroenterology 1982; 83: 963-9.","journal-title":"Gastroenterology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0022-3468(91)90715-6","article-title":"New insights into peptidergic abnormalities in Hirschprung's disease by wholemount immunohistochemistry","volume":"26","author":"Tam, P.K.; Boyd, G.P.","year":"1991","unstructured":"Tam PK, Boyd GP. New insights into peptidergic abnormalities in Hirschprung's disease by wholemount immunohistochemistry. 7 Pediatr Surg 1991; 26: 595-7.","journal-title":"7 Pediatr Surg"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0022-3468(93)90519-Q","article-title":"Immunocytochemistry for neuronal markers shows deficiencies in conventional histology in the treatment of Hirschprung's disease","volume":"28","author":"Romanska, H.M.; Bishop, A.E.; Brereton, R.J.; Spitz, L.; Polak, J.M.","year":"1993","unstructured":"Romanska HM, Bishop AE, Brereton RJ, Spitz L, Polak JM. Immunocytochemistry for neuronal markers shows deficiencies in conventional histology in the treatment of Hirschprung's disease. J Pediatr Surg 1993; 28: 1059-62.","journal-title":"J Pediatr Surg"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00266839","article-title":"Fine structure of neurons synthesizing vasoactive intestinal peptide in the human colon from patients with Hirschprung's disease","volume":"93","author":"Tsuto, T.; Obata-Tsuto, H.L.; Iwai, N.; Takahashi, T.; Ibata, Y.","year":"1989","unstructured":"Tsuto T, Obata-Tsuto HL, Iwai N, Takahashi T, Ibata Y. Fine structure of neurons synthesizing vasoactive intestinal peptide in the human colon from patients with Hirschprung's disease. Histochemistry 1989; 93: 1-8.","journal-title":"Histochemistry"},{"key":"ref_27","first-page":"164","article-title":"Is the reduction of VIP the clue to the pathophysiology of Hirschprung's disease?","volume":"45","author":"Larsson, L.T.; Sundler, F.","year":"1990","unstructured":"Larsson LT, Sundler F. Is the reduction of VIP the clue to the pathophysiology of Hirschprung's disease? Z Kinderchir 1990; 45: 164-6.","journal-title":"Z Kinderchir"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF00319630","article-title":"A novel neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), in human intestine: evidence for reduced content in Hirschprung's disease","volume":"269","author":"Shen, Z.; Larsson, L.T.; Malmfors, G.; Absood, A.; Hakanson, R.; Sundler, F.","year":"1992","unstructured":"Shen Z, Larsson LT, Malmfors G, Absood A, Hakanson R, Sundler F. A novel neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), in human intestine: evidence for reduced content in Hirschprung's disease. Cell Tissue Res 1992; 269: 369-74.","journal-title":"Cell Tissue Res"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0022-3468(85)80118-4","article-title":"Immunohistochemical investigations of gut hormones in the colon of patients with Hirschprung's disease","volume":"20","author":"Tsuto, T.; Okamura, H.; Fukui, K.","year":"1985","unstructured":"Tsuto T, Okamura H, Fukui K, et al. Immunohistochemical investigations of gut hormones in the colon of patients with Hirschprung's disease. Y Pediatr Surg 1985; 20: 266-70.","journal-title":"Y Pediatr Surg"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.74.1.5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T17:04:19Z","timestamp":1632848659000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.74.1.5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.74.1.5","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1,1]]}}}