{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:32:32Z","timestamp":1789903952386,"version":"4.0.1"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Disease in Childhood"],"published-print":{"date-parts":[[1996,12,1]]},"DOI":"10.1136\/adc.75.6.517","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T23:07:28Z","timestamp":1229987248000},"page":"517-520","source":"Crossref","is-referenced-by-count":133,"title":["Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy."],"prefix":"10.1136","volume":"75","author":[{"given":"A","family":"Ornoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"447","article-title":"Carbamazepine mechanism of action","author":"Macdonald, R.","year":"1989","unstructured":"Macdonald R. Carbamazepine mechanism of action. In: Levy H R, Dreifuss F E, Mattson RH, Meldram BS, Penry J K, eds. Antiepileptic drugs. 3rd Ed. New York: Raven Press, 1989:447-445."},{"key":"ref_2","first-page":"67","article-title":"Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC)","volume":"1","author":"Bertollini, R.; Mastroiacovo, P.; Segni, G.","year":"1985","unstructured":"Bertollini R, Mastroiacovo P, Segni G. Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). EurJ Epidemiol 1985;1:67-72.","journal-title":"EurJ Epidemiol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-0404.1992.tb04029.x","article-title":"Malformations in offspring of 305 epileptic women: a prospective study","volume":"85","author":"Battino, D.; Binelli, S.; Caccamo, M.L.","year":"1992","unstructured":"Battino D, Binelli S, Caccamo ML, et al. Malformations in offspring of 305 epileptic women: a prospective study. Acta Neurol Scand 1992; 85:204-7.","journal-title":"Acta Neurol Scand"},{"key":"ref_4","first-page":"122","article-title":"Evaluation of anticonvulsant drugs during pregnancy in a population-based Hungarian study","volume":"8","author":"Czeizel, A.E.; Bod, M.; Halasz, P.","year":"1992","unstructured":"Czeizel AE, Bod M, Halasz P. Evaluation of anticonvulsant drugs during pregnancy in a population-based Hungarian study. EurJEpidemiol 1992; 8:122-7.","journal-title":"EurJEpidemiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0890-6238(91)90091-S","article-title":"Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning 3 decades. Human studies","volume":"5","author":"Dansky, L.V.; Finnell, R.H.","year":"1991","unstructured":"Dansky LV, Finnell RH. Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning 3 decades. Human studies. Reprod Toxicol 1991;5:301-35.","journal-title":"Reprod Toxicol"},{"issue":"5","key":"ref_6","first-page":"94","article-title":"Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations","volume":"42","author":"Lindhout, D.; Meinardi, H.; Meijer, J.W.A.; Nau, H.","year":"1992","unstructured":"Lindhout D, Meinardi H, Meijer JWA, Nau H. Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations. Neurology 1992;42 (suppl 5):94-1 10.","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0002-9378(91)90640-D","article-title":"Antiepileptic medication in pregnancy. Late effects on the chldren's central nervous system development","volume":"164","author":"Van der Pol, M.C.; M, Hadders-Algra; J, Huisjes M.; BCL, Touwen","year":"1991","unstructured":"Van der Pol, MC, Hadders-Algra M, Huisjes M J, Touwen BCL. Antiepileptic medication in pregnancy. Late effects on the chldren's central nervous system development. Am Jf Obstet Gynecol 1991;164:121-8.","journal-title":"Am Jf Obstet Gynecol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1528-1157.1984.tb04158.x","article-title":"Teratogenicity of antiepileptic drug combinations, with special emphasis on epoxidation (of carbamazepine)","volume":"25","author":"Lindhout, D.; Hoppener, R.J.; Meinardi, H.","year":"1984","unstructured":"Lindhout D, Hoppener RJ, Meinardi H. Teratogenicity of antiepileptic drug combinations, with special emphasis on epoxidation (of carbamazepine). Epilepsia 1984;25:77-83.","journal-title":"Epilepsia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1600-0404.1991.tb04924.x","article-title":"Congenital malformations before and after the onset of maternal epilepsy","volume":"84","author":"Shakir, R.A.; Abdulwahab, B.","year":"1991","unstructured":"Shakir RA, Abdulwahab B. Congenital malformations before and after the onset of maternal epilepsy. Acta Neurol Scand 1991;84:153-6.","journal-title":"Acta Neurol Scand"},{"key":"ref_10","first-page":"68","article-title":"Malformation in infants of mothers with epilepsy receiving antiepileptic drugs","volume":"42","author":"Kaneko, S.; Otani, K.; Kondo, T.","year":"1992","unstructured":"Kaneko S, Otani K, Kondo T, et al. Malformation in infants of mothers with epilepsy receiving antiepileptic drugs. Neurology 1992;42 (suppl):68-74.","journal-title":"Neurology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM198911233212116","article-title":"Teratogenic effects of carbamazepine","volume":"321","author":"Jones, K.L.; A, Johnson K.; Adams, J.; Lacro, R.V.","year":"1989","unstructured":"Jones KL, Johnson K.A, Adams J, Lacro RV. Teratogenic effects of carbamazepine [letter]. N Engl J Med 1989;321: 1480-1.","journal-title":"N Engl J Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1056\/NEJM198906223202505","article-title":"Pattern of malformations in the children of women treated with carbamazepine during pregnancy","volume":"320","author":"Jones, K.L.; Lacro, R.V.; Johnson, K.A.; Adams, J.","year":"1989","unstructured":"Jones KL, Lacro RV, Johnson KA, Adams J. Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N EnglJ Med 1989;320: 1661-6.","journal-title":"N EnglJ Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007691-199302000-00001","article-title":"The 10,11-epoxide-10,11-diol pathway of carbamazepine in early pregnancy in maternal serum, urine and amniotic fluid. Effects of dose, comedication in relation to outcome of pregnancy","volume":"15","author":"Omtzight, J.G.C.; Los, F.J.; Meijer, J.W.A.; Lindhout, D.","year":"1993","unstructured":"Omtzight JGC, Los FJ, Meijer JWA, Lindhout D. The 10,11-epoxide-10,11-diol pathway of carbamazepine in early pregnancy in maternal serum, urine and amniotic fluid. Effects of dose, comedication in relation to outcome of pregnancy. Ther Drug Monit 1993;15: 1-10.","journal-title":"Ther Drug Monit"},{"key":"ref_14","article-title":"Bayley scales of infant development","year":"1978","unstructured":"Bayley scales of infant development. New York: Psychological Co, 1978."},{"key":"ref_15","first-page":"283","article-title":"The perception of professions in Israel","volume":"26","author":"Kraus, V.","year":"1981","unstructured":"Kraus V. The perception of professions in Israel. Megamot 1981;26:283-94.","journal-title":"Megamot"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1001\/archneur.1994.00540150044014","article-title":"Outcomes of pregnancy associated with antiepileptic drugs","volume":"51","author":"Waters, C.H.; Bellai, I.; Gott, P.S.; Shen, P.; De Giorgio, C.M.","year":"1994","unstructured":"Waters CH, Bellai I, Gott, PS, Shen P, De Giorgio CM. Outcomes of pregnancy associated with antiepileptic drugs. Arch Neurol 1994;51:250-3.","journal-title":"Arch Neurol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/jama.1994.03510340057034","article-title":"Neurodevelopment of children exposed in-utero to phenytoin and carbamazepine monotherapy","volume":"271","author":"Scolnik, D.; Nulman, I.; Rovet, J.","year":"1994","unstructured":"Scolnik D, Nulman I, Rovet J, et al. Neurodevelopment of children exposed in-utero to phenytoin and carbamazepine monotherapy. JAMA 1994;271:767-70.","journal-title":"JAMA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1001\/jama.1994.03520110028017","article-title":"Neurodevelopment after in-utero exposure to phenytoin and carbamazepine","volume":"272","author":"Jeret, J.S.","year":"1994","unstructured":"Jeret JS. Neurodevelopment after in-utero exposure to phenytoin and carbamazepine [letter]. JAMA 1994;272: 850.","journal-title":"JAMA"},{"key":"ref_19","first-page":"165","article-title":"An evaluation of whether maternal epilepsy","volume":"51","author":"Holmes, L.B.; Rosenberger, P.B.; Harvey, E.A.","year":"1995","unstructured":"Holmes LB, Rosenberger PB, Harvey EA. An evaluation of whether maternal epilepsy (no drugs) is associated with an increased rate of cognitive dysfunction. Teratology 1995;51: 165 (abst 37).","journal-title":"Teratology; is associated with an increased rate of cognitive dysfunction"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0145-2134(96)00014-2","article-title":"The developmental outcome of children born to heroin dependent mothers raised at home or adopted","volume":"20","author":"Ornoy, A.; Michailevskaya, V.; Lukashov, I.; Bar-Hamburger, R.; Harel, S.","year":"1996","unstructured":"Ornoy A, Michailevskaya V, Lukashov I, Bar-Hamburger R, Harel S. The developmental outcome of children born to heroin dependent mothers raised at home or adopted. Child Abuse Negl 1996;20:385-96.","journal-title":"Child Abuse Negl"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJM199005313222204","article-title":"Prenatal prediction of risk of the fetal hydantoin syndrome","volume":"322","author":"Buehler, B.A.; Delmont, D.; Van Waes, M.; Finell, R.H.","year":"1990","unstructured":"Buehler BA, Delmont D, Van Waes M, Finell RH. Prenatal prediction of risk of the fetal hydantoin syndrome. NEnglJ Med 1990;322:1567-72.","journal-title":"NEnglJ Med"},{"key":"ref_22","first-page":"16601","article-title":"Prenatal prediction of risk of fetal hydantoin syndrome","volume":"329","author":"Buehler, B.A.; Bick, K.; Delmont, D.","year":"1993","unstructured":"Buehler BA, Bick K, Delmont D. Prenatal prediction of risk of fetal hydantoin syndrome. N EnglJ7Med 1993;329: 16601."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/tera.1420510202","article-title":"Anticonvulsant teratogenesis: 3. Possible metabolic basis","volume":"51","author":"Raymond, G.V.; Buehler, B.A.; Finell, R.H.; Holmes, L.W.","year":"1995","unstructured":"Raymond GV, Buehler BA, Finell RH, Holmes LW. Anticonvulsant teratogenesis: 3. Possible metabolic basis. Teratology 1995;51:55-6.","journal-title":"Teratology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/tera.1420490316","article-title":"Anticonvulsant teratogenesis: I. A study design for newborn infants","volume":"49","author":"Holmes, L.B.; Harvey, E.A.; Brown, K.S.; Hayes, A.M.; Khoshbin, S.","year":"1994","unstructured":"Holmes LB, Harvey EA, Brown KS, Hayes AM, Khoshbin S. Anticonvulsant teratogenesis: I. A study design for newborn infants. Teratology 1994;49:202-7.","journal-title":"Teratology"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/adc.75.6.517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T21:50:21Z","timestamp":1601070621000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/adc.75.6.517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12,1]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/adc.75.6.517","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12,1]]}}}