{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:56:10Z","timestamp":1789372570781,"version":"build-2803163510"},"reference-count":18,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To investigate the relation between total serum IgE at 0.5\u20133 and 3\u20136 years, and the risk of allergic sensitisation and persistent wheezing up to 8 years of age.<\/jats:p><\/jats:sec><jats:sec sec-type=\"methods\"><jats:title>METHODS<\/jats:title><jats:p>Prospective follow up study of 45 infants with highly recurrent wheezing, no allergic symptoms, and negative skin tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the last follow up year, 15 children still suffered from wheezing. Five wheeze-free and four episodically wheezing children had become sensitised. No association was found between early (0.5\u20133 years) IgE z scores and the recurrence of wheezing during follow up, or atopic sensitisation. IgE z scores at 3\u20136 years were significantly higher in children with positive skin tests (p\u2009=\u20090.013), but were still not associated with recurrence of wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In subjects with frequent early wheezing and no signs of atopy, early total serum IgE measurements are not predictive of outcome.<\/jats:p><\/jats:sec>","DOI":"10.1136\/adc.85.1.23","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:32:32Z","timestamp":1027765952000},"page":"23-25","source":"Crossref","is-referenced-by-count":17,"title":["Total serum IgE and outcome in infants with recurrent wheezing"],"prefix":"10.1136","volume":"85","author":[{"given":"F","family":"Rusconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Patria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G U","family":"Cislaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sideri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Gagliardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"2021071919250976000_85.1.23.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200502"},{"key":"2021071919250976000_85.1.23.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09091880"},{"key":"2021071919250976000_85.1.23.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70110-7"},{"key":"2021071919250976000_85.1.23.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1976.tb01411.x"},{"key":"2021071919250976000_85.1.23.5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0091-6749(79)90046-0","article-title":"Immunoglobulin E response during viral infections.","volume":"64","author":"Perelmutter","year":"1979","journal-title":"J Allergy Clin Immunol"},{"key":"2021071919250976000_85.1.23.6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1164\/ajrccm.152.5.7582283","article-title":"The relationship between parental and children's serum IgE and asthma.","volume":"152","author":"Burrows","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2021071919250976000_85.1.23.7","unstructured":"Logan WPD Cushion AA (1958) Morbidity statistics from general practice 14. 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