{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:47:12Z","timestamp":1785422832829,"version":"3.56.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acupunct Med"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intravenous injection of lipopolysaccharide (LPS) stimulates macrophages to release proinflammatory cytokines and nitric oxide (NO). This results in hypotension, vascular hyporeactivity and multiple organ failure (eg, liver injury) in rats. In rats with endotoxin shock, electro-acupuncture (EA) of \u2018Neiguan\u2019 (PC6) retrieved blood pressure and reduced plasma concentrations of NO. The authors evaluated whether EA at PC6 could alleviate the development of liver injury and dysfunction in endotoxic rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 28 male adult Wistar rats were included in this study. Rats received intravenous LPS (10 mg\/kg for 4 h) or saline for 4 h followed by EA at PC6 acupuncture point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated biochemical parameters of liver injury and marked infiltration of neutrophils into liver tissues caused by LPS were significantly attenuated by EA. However, hypotension, tachycardia and raised production of plasma NO were not suppressed by EA at PC6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that EA at PC6 should be further investigated as a possible adjuvant therapy for endotoxin-induced liver dysfunction. Its mechanism of action needs further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/aim.2010.003525","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T20:35:22Z","timestamp":1312922122000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Electro-Acupuncture at \u2018neiguan\u2014 (Pc6) Attenuates Liver Injury in Endotoxaemic Rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Hwan-Wun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan"},{"name":"Department of Medicine, College of Medicine, Tzu-Chi University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mou-Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ming","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Taipei Veterans Hospital and National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hui","family":"Liao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, National Defence Medical Centre, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, National Defence Medical Centre, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"bibr1-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043632"},{"key":"bibr2-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107001-00016"},{"key":"bibr3-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800800124"},{"key":"bibr4-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1159\/000316286"},{"key":"bibr5-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.6.991"},{"key":"bibr6-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.08.006"},{"key":"bibr7-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq317"},{"key":"bibr8-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2045-8"},{"key":"bibr9-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181e7e9ba"},{"key":"bibr10-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.108100"},{"key":"bibr11-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000255288.68199.eb"},{"key":"bibr12-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.01029.x"},{"key":"bibr13-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1307.039"},{"key":"bibr14-aim.2010.003525","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70095-9"},{"key":"bibr15-aim.2010.003525","first-page":"16","volume":"24","author":"Meng 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